Imperial College London
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DrPascaleKropf

Faculty of Medicine, Department of Infectious Disease

Reader in Immunology
 
 
 
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Contact

 

+44 (0)20 7594 1755p.kropf

 
 
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Location

 

120Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Corware:2014:10.1186/1743-7075-11-51,
author = {Corware, K and Yardley, V and Mack, C and Schuster, S and Al-Hassi, H and Herath, S and Bergin, P and Modolell, M and Munder, M and Mueller, I and Kropf, P},
doi = {10.1186/1743-7075-11-51},
journal = {Nutrition & Metabolism},
title = {Protein energy malnutrition increases arginase activity in monocytes and macrophages},
url = {http://dx.doi.org/10.1186/1743-7075-11-51},
volume = {11},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factorin susceptibility to infectious diseases.Methods: In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes andmacrophages to upregulate arginase, an enzyme associated with immunosuppression and increased pathogenreplication.Results: Our results show that monocytes and macrophages are significantly increased in the bone marrow andblood of mice fed on a protein low diet. No alteration in the capacity of bone marrow derived macrophagesisolated from malnourished mice to phagocytose particles, to produce the microbicidal molecule nitric oxide andto kill intracellular Leishmania parasites was detected. However, macrophages and monocytes from malnourished miceexpress significantly more arginase both in vitro and in vivo. Using an experimental model of visceral leishmaniasis, weshow that following protein energy malnutrition, the increased parasite burden measured in the spleen of these micecoincided with increased arginase activity and that macrophages provide a more permissive environment for parasitegrowth.Conclusions: Taken together, these results identify a novel mechanism in protein energy malnutrition that mightcontributes to increased susceptibility to infectious diseases by upregulating arginase activity in myeloid cells.
AU  - Corware,K
AU  - Yardley,V
AU  - Mack,C
AU  - Schuster,S
AU  - Al-Hassi,H
AU  - Herath,S
AU  - Bergin,P
AU  - Modolell,M
AU  - Munder,M
AU  - Mueller,I
AU  - Kropf,P
DO  - 10.1186/1743-7075-11-51
PY  - 2014///
SN  - 1743-7075
TI  - Protein energy malnutrition increases arginase activity in monocytes and macrophages
T2  - Nutrition & Metabolism
UR  - http://dx.doi.org/10.1186/1743-7075-11-51
UR  - http://hdl.handle.net/10044/1/27755
VL  - 11
ER  -
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