Imperial College London
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DrPeiLai

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Associate
 
 
 
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Contact

 

p.lai

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2021:10.1042/BST20201173,
author = {Li, JKH and Lai, PF and Tribe, RM and Johnson, MR},
doi = {10.1042/BST20201173},
journal = {Biochemical Society Transactions},
pages = {997--1011},
title = {Transcription factors regulated by cAMP in smooth muscle of the myometrium at human parturition.},
url = {http://dx.doi.org/10.1042/BST20201173},
volume = {49},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cyclic adenosine monophosphate (cAMP) contributes to maintenance of a quiescent (relaxed) state in the myometrium (i.e. uterine smooth muscle) during pregnancy, which most commonly has been attributed to activation of protein kinase A (PKA). PKA-mediated phosphorylation of cytosolic contractile apparatus components in myometrial smooth muscle cells (mSMCs) are known to promote relaxation. Additionally, PKA also regulates nuclear transcription factor (TF) activity to control expression of genes important to the labour process; these are mostly involved in actin-myosin interactions, cell-to-cell connectivity and inflammation, all of which influence mSMC transition from a quiescent to a contractile (pro-labour) phenotype. This review focuses on the evidence that cAMP modulates the activity of TFs linked to pro-labour gene expression, predominantly cAMP response element (CRE) binding TFs, nuclear factor κB (NF-κB), activator protein 1 (AP-1) family and progesterone receptors (PRs). This review also considers the more recently described exchange protein directly activated by cAMP (EPAC) that may oppose the pro-quiescent effects of PKA, as well as explores findings from other cell types that have the potential to be of novel relevance to cAMP action on TF function in the myometrium.
AU  - Li,JKH
AU  - Lai,PF
AU  - Tribe,RM
AU  - Johnson,MR
DO  - 10.1042/BST20201173
EP  - 1011
PY  - 2021///
SN  - 0300-5127
SP  - 997
TI  - Transcription factors regulated by cAMP in smooth muscle of the myometrium at human parturition.
T2  - Biochemical Society Transactions
UR  - http://dx.doi.org/10.1042/BST20201173
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33860781
UR  - https://portlandpress.com/biochemsoctrans/article/49/2/997/228374/Transcription-factors-regulated-by-cAMP-in-smooth
UR  - http://hdl.handle.net/10044/1/88142
VL  - 49
ER  -
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