Imperial College London

DrPeiLai

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Research Associate
 
 
 
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Contact

 

p.lai

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Research specialism & funding

The primary focus of my research is to determine what initiates spontaneous contractions in the myometrium (i.e. the smooth muscle of the uterus) at the end of pregnancy to begin the process of labour. I mainly study myometrium tissue function in the context of healthy term pregnancies, which is needed to ascertain which parts of its contraction-relevant physiological mechanisms goes wrong to result in abnormal timing of spontaneous labour; particularly preterm (<37 weeks of gestation) labour.  


SPECIFIC AREAS OF INTEREST:

  • Spatio-temporal effects of agents that promote cyclic AMP (cAMP) signalling on human myometrial tissue contractility and how they can be influenced by progesterone (P4) signalling
  • Omics-based analysis of parturition-driven changes in human myometrial smooth muscle

PREVIOUS PROJECT GRANTS:

  • Action Medical Research (AMR) project grant, 2016-2018: Enhancement of Progesterone Function by PKA-driven cAMP Signalling in the Prevention of Preterm Labour
  • Action Medical Research (AMR) project grant, 2011-2014: PDE4 inhibitors: a treatment for mothers and babies at risk of preterm delivery?

TRAVEL AWARDS/BURSARIES:

  • Biochemical Society Early Career Member Bursary - poster presentation at the 'Nanodomains in Cyclic Nucleotide Signalling' society-organised meeting (London, UK; 16-18th September 2019)
  • Society of Reproductive Investigation (SRI) Travel Award - oral presentation at the SRI Annual Meeting (San Diego, USA; 6-10th March 2018)