Publications
230 results found
Zhou L, Jones SCP, Angen O, et al., 2008, PCR specific for <i>Actinobacillus pleuropneumoniae</i> serotype 3, VETERINARY RECORD, Vol: 162, Pages: 648-+, ISSN: 0042-4900
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- Citations: 10
Tegetmeyer HE, Jones SCP, Langford PR, et al., 2008, ISAp1<i>1</i>, a novel insertion element of <i>Actinobacillus</i> <i>pleuropneumoniae</i>, prevents ApxIV-based serological detection of serotype 7 strain AP76, VETERINARY MICROBIOLOGY, Vol: 128, Pages: 342-353, ISSN: 0378-1135
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- Citations: 68
Oldfield NJ, Donovana EA, Worrall KE, et al., 2008, Identification and characterization of novel antigenic vaccine candidates of <i>Actinobacillus pleuropneumoniae</i>, VACCINE, Vol: 26, Pages: 1942-1954, ISSN: 0264-410X
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- Citations: 25
Foote SJ, Bosse JT, Bouvevitch AB, et al., 2008, The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)., J Bacteriol, Vol: 190, Pages: 1495-1496
There are 16 capsule-based serotypes of Actinobacillus pleuropneumoniae, all of which are capable of causing disease in pigs. Here we report the finished and annotated genome sequence of the reference serotype 5b strain L20. This strain has a rough appearance and readily forms biofilms, as is typical for most field isolates.
Zhou L, Jones SCP, Angen O, et al., 2008, Multiplex PCR that can distinguish between immunologically cross-reactive serovar 3, 6, and 8 <i>Actinobacillus pleuropneumoniae</i> strains, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 46, Pages: 800-803, ISSN: 0095-1137
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- Citations: 33
Sinha S, Ambur OH, Langford PR, et al., 2008, Reduced DNA binding and uptake in the absence of DsbA1 and DsbA2 of <i>Neisseria meningitidis</i> due to inefficient folding of the outer-membrane secretin PilQ, MICROBIOLOGY-SGM, Vol: 154, Pages: 217-225, ISSN: 1350-0872
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- Citations: 21
Kerr JR, Christian P, Hodgetts A, et al., 2007, Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments, JOURNAL OF CLINICAL PATHOLOGY, Vol: 60, Pages: 113-116, ISSN: 0021-9746
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- Citations: 17
Hodgetts A, Levin M, Kroll J S, et al., 2007, Biomarker discovery in infectious diseases using SELDI, Future Microbiology, Vol: 2, Pages: 35-49
Fung WWM, O'Dwyer CA, Sinha S, et al., 2006, Presence of copper- and zinc-containing superoxide dismutase in commensal <i>Haemophilus haemolyticus</i> isolates can be used as a marker to discriminate them from nontypeable <i>H-influenzae</i> isolates, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 44, Pages: 4222-4226, ISSN: 0095-1137
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- Citations: 23
Bossé JT, Zhou L, Kroll JS, et al., 2006, High-throughput identification of conditionally essential genes in bacteria: from STM to TSM., Infect Disord Drug Targets, Vol: 6, Pages: 241-262, ISSN: 1871-5265
Signature-tagged mutagenesis (STM) provided the first widely applicable high-throughput method for detecting conditionally essential genes in bacteria by using negative selection to screen large pools of transposon (Tn) mutants. STM requires no prior knowledge of the bacterium's genome sequence, and has been used to study a large number of Gram-positive and Gram-negative species, greatly expanding the repertoires of known virulence factors for these organisms. Originally, hybridization of radiolabelled probes to colony or dot blots was used to detect differences in populations of tagged mutants before and after growth under a selective condition. Modifications of the tag detection method involving polymerase chain reaction (PCR) amplification and visualisation by gel electrophoresis have been developed and can be automated through the use of robotics. Genetic footprinting is another negative selection technique that uses PCR amplification to detect loss of mutants from a pool. Unlike PCR-STM, this technique allows direct amplification of Tn-flanking sequences. However, it requires the bacterium's whole genome sequence in order to design specific primers for every gene of interest. More recently, a number of techniques have been described that combine the negative-selection principle of STM and genetic footprinting with the genome-wide screening power of DNA microarrays. These techniques, although also requiring whole genome sequences, use either a form of linker-mediated or semi-random PCR to amplify and label Tn-flanking regions for hybridization to microarrays. The superior sensitivity microarray detection allows greater numbers of mutants to be screened per pool, as well as determination of the coverage/distribution of insertions in the library prior to screening, two significant advantages over STM.
Haralambous E, Dolly SO, Hibberd ML, et al., 2006, Factor H, a regulator of complement activity is a major determinant of meningococcal disease susceptibility in UK Caucasian patients., Scand J Infect Dis, Pages: 764-771
O'Dwyer CA, Langford PR, Kroll JS, 2005, A novel neisserial shuttle plasmid: A useful new tool for meningococcal research, FEMS MICROBIOLOGY LETTERS, Vol: 251, Pages: 143-147, ISSN: 0378-1097
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- Citations: 4
Jacobsen I, Gerstenberger J, Gruber AD, et al., 2005, Deletion of the ferric uptake regulator fur impairs the in vitro growth and virulence of <i>Actinobacillus pleuropneumoniae</i>, INFECTION AND IMMUNITY, Vol: 73, Pages: 3740-3744, ISSN: 0019-9567
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- Citations: 33
Redfield RJ, Cameron ADS, Qian Q, et al., 2005, A novel CRP-dependent of competence genes in regulon controls expression <i>Haemophilus influenzae</i>, JOURNAL OF MOLECULAR BIOLOGY, Vol: 347, Pages: 735-747, ISSN: 0022-2836
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- Citations: 96
Ammendola S, Ajello M, Pasquali P, et al., 2005, Differential contribution of <i>sodC1</i> and <i>sodC2</i> to intracellular survival and pathogenicity of <i>Salmonella enterica</i> serovar Choleraesuis, MICROBES AND INFECTION, Vol: 7, Pages: 698-707, ISSN: 1286-4579
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- Citations: 24
Kampmann B, Hemingway C, Stephens A, et al., 2005, Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma., Journal of Clinical Investigation, Vol: 115, Pages: 2480-2488
O'Dwyer CA, Reddin K, Martin D, et al., 2004, Expression of heterologous antigens in commensal <i>Neisseria</i> spp.:: Preservation of conformational epitopes with vaccine potential, INFECTION AND IMMUNITY, Vol: 72, Pages: 6511-6518, ISSN: 0019-9567
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- Citations: 41
Sinha S, Langford PR, Kroll JS, 2004, Functional diversity of three different DsbA proteins from <i>Neisseria meningitidis</i>, MICROBIOLOGY-SGM, Vol: 150, Pages: 2993-3000, ISSN: 1350-0872
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- Citations: 41
Hodgetts A, Bossé JT, Kroll JS, et al., 2004, Analysis of differential protein expression in <i>Actinobacillus pleuropneumoniae</i> by Surface Enhanced Laser Desorption Ionisation-ProteinChip™ (SELDI) technology, VETERINARY MICROBIOLOGY, Vol: 99, Pages: 215-225, ISSN: 0378-1135
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- Citations: 10
Bossé JT, Nash JHE, Kroll JS, et al., 2004, Harnessing natural transformation in <i>Actinobacillus pleuropneumoniae</i>:: a simple method for allelic replacements, FEMS MICROBIOLOGY LETTERS, Vol: 233, Pages: 277-281, ISSN: 0378-1097
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- Citations: 20
Bossà JT, Nash JHE, Simon Kroll J, et al., 2004, Harnessing natural transformation in<i>Actinobacillus pleuropneumoniae</i>: a simple method for allelic replacements, FEMS Microbiology Letters, Vol: 233, Pages: 277-281, ISSN: 0378-1097
Edwards-Jones B, Langford PR, Kroll JS, et al., 2004, The role of the <i>Shigella flexneri yihE</i> gene in LPS synthesis and virulence, MICROBIOLOGY-SGM, Vol: 150, Pages: 1079-1084, ISSN: 1350-0872
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- Citations: 9
Beddek AJ, Sheehan BJ, Bossé JT, et al., 2004, Two TonB systems in <i>Actinobacillus pleuropneumoniae</i>:: Their roles in iron acquisition and virulence, INFECTION AND IMMUNITY, Vol: 72, Pages: 701-708, ISSN: 0019-9567
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- Citations: 45
Edwards-Jones B, Langford PR, Kroll JS, et al., 2004, The role of the Shigella flexneri yihE gene in LPS synthesis and virulence, Microbiology, Vol: 150, Pages: 1079-1084, ISSN: 1350-0872
Previously, the authors have shown that inactivation of Shigella flexneri yihE, a gene of unknown function upstream of dsbA, which encodes a periplasmic disulphide catalyst, results in a global change of gene expression. Among the severely down-regulated genes are galETKM, suggesting that the yihE mutant, Sh54, may inefficiently produce the UDP-glucose and UDP-galactose required for LPS synthesis. This paper demonstrates that LPS synthesis in Sh54 is impaired. As a result, Sh54 is unable to polymerize host cell actin, due to aberrant localization of IcsA, or to cause keratoconjunctivitis in guinea pigs. Furthermore, Sh54 is more sensitive to some antimicrobial agents, and exhibits epithelial cytotoxicity characteristic of neither wild-type nor dsbA mutants. Supplying galETK in trans restores LPS synthesis and corrects all the defects. Hence, it is clear that the Shigella yihE gene is important not only in regulating global gene expression, as shown previously, but also in virulence through LPS synthesis via regulating the expression of the galETK operon. © 2004 SGM.
Sheehan BJ, Bossé JT, Beddek AJ, et al., 2003, Identification of <i>Actinobacillus pleuropneumoniae</i> genes important for survival during infection in its natural host, INFECTION AND IMMUNITY, Vol: 71, Pages: 3960-3970, ISSN: 0019-9567
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- Citations: 72
Dunn KLR, Farrant JL, Langford PR, et al., 2003, Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated <i>Neisseria meningitidis</i> from phagocytosis by human monocytes/macrophages, INFECTION AND IMMUNITY, Vol: 71, Pages: 1604-1607, ISSN: 0019-9567
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- Citations: 30
Li MS, Farrant JL, Langford PR, et al., 2003, Identification and characterization of genomic loci unique to the Brazilian purpuric fever clonal group of <i>H-influenzae</i> biogroup aegyptius:: functionality explored using meningococcal homology, MOLECULAR MICROBIOLOGY, Vol: 47, Pages: 1101-1111, ISSN: 0950-382X
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- Citations: 18
Ali TR, Li M-S, Langford PR, 2003, Monitoring gene expression using DNA arrays., Methods Mol Med, Vol: 71, Pages: 119-134, ISSN: 1543-1894
Kroll JS, Farrant JL, Tyler S, et al., 2002, Characterisation and genetic organisation of a 24-MDa plasmid from the Brazilian Purpuric Fever clone of <i>Haemophilus influenzae</i> biogroup aegyptius, PLASMID, Vol: 48, Pages: 38-48, ISSN: 0147-619X
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- Citations: 9
Garside LH, Collins M, Langford PR, et al., 2002, <i>Actinobacillus pleuropneumoniae</i> serotype 1 carrying the defined <i>aroA</i> mutation is fully avirulent in the pig, RESEARCH IN VETERINARY SCIENCE, Vol: 72, Pages: 163-167, ISSN: 0034-5288
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- Citations: 11
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