Imperial College London
Alternate

ProfessorPaulLangford

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3359p.langford Website

 
 
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Location

 

236Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{da:2022:10.3389/fmicb.2021.773284,
author = {da, Silva G and Gonçalves, O and Rosa, J and França, K and Bosse, JT and Santana, M and Langford, P and Bazzolli, D},
doi = {10.3389/fmicb.2021.773284},
journal = {Frontiers in Microbiology},
pages = {1--14},
title = {Mobile genetic elements drive antimicrobial resistance gene spread in Pasteurellaceae species},
url = {http://dx.doi.org/10.3389/fmicb.2021.773284},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mobile genetic elements (MGEs) and antimicrobial resistance (AMR) drive important ecological relationships in microbial communities and pathogen-host interaction. In this study, we investigated the resistome-associated mobilome in 345 publicly available Pasteurellaceae genomes, a large family of Gram-negative bacteria including major human and animal pathogens. We generated a comprehensive dataset of the mobilome integrated into genomes, including 10,820 insertion sequences, 2,939 prophages, and 43 integrative and conjugative elements. Also, we assessed plasmid sequences of Pasteurellaceae. Our findings greatly expand the diversity of MGEs for the family, including a description of novel elements. We discovered that MGEs are comparable and dispersed across species and that they also co-occur in genomes, contributing to the family's ecology via gene transfer. In addition, we investigated the impact of these elements in the dissemination and shaping of AMR genes. A total of 55 different AMR genes were mapped to 721 locations in the dataset. MGEs are linked with 77.6% of AMR genes discovered, indicating their important involvement in the acquisition and transmission of such genes. This study provides an uncharted view of the Pasteurellaceae by demonstrating the global distribution of resistance genes linked with MGEs.
AU  - da,Silva G
AU  - Gonçalves,O
AU  - Rosa,J
AU  - França,K
AU  - Bosse,JT
AU  - Santana,M
AU  - Langford,P
AU  - Bazzolli,D
DO  - 10.3389/fmicb.2021.773284
EP  - 14
PY  - 2022///
SN  - 1664-302X
SP  - 1
TI  - Mobile genetic elements drive antimicrobial resistance gene spread in Pasteurellaceae species
T2  - Frontiers in Microbiology
UR  - http://dx.doi.org/10.3389/fmicb.2021.773284
UR  - https://www.frontiersin.org/articles/10.3389/fmicb.2021.773284/full
UR  - http://hdl.handle.net/10044/1/92895
VL  - 12
ER  -
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