I am a Clinical Reader in the Division of Brain Sciences and Consultant Neurologist at Imperial College Healthcare NHS Trust. My undergraduate training was in Oxford, and I subsequently carried out a PhD with Professor Masud Husain at Imperial and the UCL Institute of Cognitive Neuroscience. Following this I completed Specialist Training and a NIHR Clinical Lectureship in London, before a Visiting Scholarship to Sydney, with Professor Simon Lewis and Professor John Hodges.
My work focusses on the cognitive deficits that are caused by Neurological conditions such as stroke and neurodegenerative disease, and developing treatments for these disorders. In particular, I am interested in disorders of attention and memory, and the use of imaging techniques to understand how they are caused. The aim of understanding these problems is to improve therapeutic effectiveness and I am actively involved in the development and assessment of novel treatments. I have carried out a number of drug trials in stroke patients with impaired attention, and am the lead investigator for a NIHR-funded treatment trial for Alzheimer's Disease. In addition, I am examining how novel therapies, such as brain stimulation, can improve attention after stroke.
I am involved in a number of collaborations, both within and outside Imperial College-these include studies examining the links between hearing loss and dementia, proof-of-concept drug trials in dementia and UK-wide studies assessing multiple biomarkers in the earliest stages of Alzheimer's Disease.
I have appeared on Sky News, ITV News and BBC World to discuss recent developments in the field of dementia, as well as a short film for the Guardian describing the spatial neglect syndrome (a common disorder which follows stroke).
Current and recent support for my research has come from the National Institute of Health Research, the Medical Research Council and the Biomedical Research Centre at Imperial College.
et al., 2020, Reward sensitivity predicts dopaminergic response in spatial neglect, Cortex, Vol:122, ISSN:0010-9452, Pages:213-224
Malhotra P, 2019, Impairments of attention in Alzheimer’s disease, Current Opinion in Psychology, Vol:29, ISSN:2352-250X, Pages:41-48
et al., Clinical 18F-FDG and amyloid brain positron emission tomography/CT in the investigation of cognitive impairment: where are we now?, British Journal of Radiology, Vol:92, ISSN:0007-1285
et al., 2019, Self-perspective in episodic memory after parietal damage and in healthy ageing, Neuropsychologia, Vol:124, ISSN:0028-3932, Pages:171-181
et al., 2018, Clinical utility of amyloid PET imaging with (18)F-florbetapir: a retrospective study of 100 patients., J Neurol Neurosurg Psychiatry, Vol:89, Pages:294-299
et al., 2018, A randomised double-blind, placebo-controlled crossover study of single-dose guanfacine in unilateral neglect following stroke, Journal of Neurology, Neurosurgery and Psychiatry, Vol:89, ISSN:1468-330X, Pages:593-598
et al., 2017, Motor dexterity and strength depend upon integrity of the attention-control system, Proceedings of the National Academy of Sciences of the United States of America, Vol:115, ISSN:0027-8424, Pages:E536-E545
Malhotra PA, Russell C, 2015, Does stroke imaging provide insights into the neural basis of cognition?, Current Neurology and Neuroscience Reports, Vol:15, ISSN:1534-6293
Li K, Malhotra PA, 2015, Spatial Neglect, Practical Neurology, Vol:15, ISSN:1474-7766, Pages:333-339
et al., 2014, The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis, Journal of Neurology, Vol:261, ISSN:0340-5354, Pages:600-603
et al., 2013, Reward modulates spatial neglect, Journal of Neurology Neurosurgery and Psychiatry, Vol:84, ISSN:0022-3050, Pages:366-369
Malhotra P, Coulthard EJ, Husain M, 2009, Role of right posterior parietal cortex in maintaining attention to spatial locations over time, Brain, Vol:132, ISSN:0006-8950, Pages:645-660
Venkataraman A, Perry R, Malhotra P, Young Onset Dementia
et al., 2016, Chapter 15 - Motivation and attention following hemispheric stroke, Progress in Brain Research, Editor(s): Studer, Knecht, ELSEVIER SCIENCE BV, Pages:343-366, ISBN:978-0-444-63701-7