Imperial College London

DrPareshMalhotra

Faculty of MedicineDepartment of Medicine

Reader in Cognitive & Behavioural Neurology
 
 
 
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Contact

 

+44 (0)20 3313 5525p.malhotra

 
 
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Location

 

Lab BlockCharing Cross Campus

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Summary

 

Summary

I am a Clinical Reader in the Division of Brain Sciences and Consultant Neurologist at Imperial College Healthcare NHS Trust. My undergraduate training was in Oxford, and I subsequently carried out a PhD with Professor Masud Husain at Imperial and the UCL Institute of Cognitive Neuroscience. Following this I completed Specialist Training and a NIHR Clinical Lectureship in London, before a Visiting Scholarship to Sydney, with Professor Simon Lewis and Professor John Hodges.

My work focusses on the cognitive deficits that are caused by Neurological conditions such as stroke and neurodegenerative disease, and developing treatments for these disorders. In particular, I am interested in disorders of attention and memory, and the use of imaging techniques to understand how they are caused. The aim of understanding these problems is to improve therapeutic effectiveness and I am actively involved in the development and assessment of novel treatments. I have carried out a number of drug trials in stroke patients with impaired attention, and am the lead investigator for a NIHR-funded treatment trial for Alzheimer's Disease. In addition, I am examining how novel therapies, such as brain stimulation, can improve attention after stroke.

I am involved in a number of collaborations, both within and outside Imperial College-these include studies examining the links between hearing loss and dementia, proof-of-concept drug trials in dementia and UK-wide studies assessing multiple biomarkers in the earliest stages of Alzheimer's Disease.


I have appeared on Sky News, ITV News and BBC World to discuss recent developments in the field of dementia, as well as a short film for the Guardian describing the spatial neglect syndrome (a common disorder which follows stroke).

Current and recent support for my research has come from the National Institute of Health Research, the Medical Research Council and the Biomedical Research Centre at Imperial College.

Selected Publications

Journal Articles

Dalmaijer ES, Li KMS, Gorgoraptis N, et al., 2018, Randomised, double-blind, placebo-controlled crossover study of single-dose guanfacine in unilateral neglect following stroke, Journal of Neurology Neurosurgery and Psychiatry, Vol:89, ISSN:0022-3050, Pages:593-598

Carswell CJ, Win Z, Muckle K, et al., 2018, Clinical utility of amyloid PET imaging with (18)F-florbetapir: a retrospective study of 100 patients., J Neurol Neurosurg Psychiatry, Vol:89, Pages:294-299

Rinne P, Hassan M, Fernandes C, et al., 2018, Motor dexterity and strength depend upon integrity of the attention-control system, Proceedings of the National Academy of Sciences of the United States of America, Vol:115, ISSN:0027-8424, Pages:E536-E545

Li K, Malhotra PA, 2015, Spatial neglect., Pract Neurol, Vol:15, Pages:333-339

Malhotra PA, Russell C, 2015, Does Stroke Imaging Provide Insights into the Neural Basis of Cognition?, Current Neurology and Neuroscience Reports, Vol:15, ISSN:1528-4042

Devine MJ, Bentley P, Jones B, et al., 2014, The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis, Journal of Neurology, Vol:261, ISSN:0340-5354, Pages:600-603

Malhotra PA, Soto D, Li K, et al., 2013, Reward modulates spatial neglect, Journal of Neurology Neurosurgery and Psychiatry, Vol:84, ISSN:0022-3050, Pages:366-369

Malhotra P, Coulthard EJ, Husain M, 2009, Role of right posterior parietal cortex in maintaining attention to spatial locations over time, Brain, Vol:132, ISSN:0006-8950, Pages:645-660

Chapters

Olgiati E, Russell C, Soto D, et al., 2016, Motivation and attention following hemispheric stroke, MOTIVATION: THEORY, NEUROBIOLOGY AND APPLICATIONS, Editor(s): Studer, Knecht, ELSEVIER SCIENCE BV, Pages:343-366, ISBN:978-0-444-63701-7

More Publications