Summary
I am Head of the Division of Neurology in the Department of Brain Sciences and a Consultant Neurologist at Imperial College Healthcare NHS Trust. My undergraduate training was in Oxford, and I subsequently carried out a PhD with Professor Masud Husain at Imperial and the UCL Institute of Cognitive Neuroscience. Following this I completed Specialist Training and a NIHR Clinical Lectureship in London, before a Visiting Scholarship to Sydney, with Professor Simon Lewis and Professor John Hodges.
My work focusses on the cognitive deficits that are caused by Neurological conditions such as stroke and neurodegenerative disease, and developing treatments for these disorders. In particular, I am interested in disorders of attention and memory, and the use of imaging techniques to understand how they are caused. The aim of understanding these problems is to improve therapeutic effectiveness and I am actively involved in the development and assessment of novel treatments. I have carried out a number of drug trials in stroke patients with impaired attention, and am the lead investigator for a NIHR-funded treatment trial for Alzheimer's Disease. In addition, I am examining how novel therapies, such as brain stimulation, can improve attention after stroke.
I am involved in a number of collaborations, both within and outside Imperial College-these include studies examining the links between hearing loss and dementia and UK-wide studies assessing multiple biomarkers in the earliest stages of Alzheimer's Disease. In addition, I am an Associate Member of the UK Dementia Research Institute, based at the Care Research and Technology Centre, and am also part of the ACORD collaboration.
I have appeared on Sky News, ITV News and BBC World to discuss recent developments in the field of dementia, as well as a short film for the Guardian describing the spatial neglect syndrome (a common disorder which follows stroke). Work that I have led or been involved in has been reported in The Times, The Guardian, The Daily Telegraph and wider international press.
Current and recent support for my research has come from the Alzheimer's Society, the National Institute of Health Research, the Medical Research Council, and the Biomedical Research Centre at Imperial College.
Selected Publications
Journal Articles
Loreto F, Gontsarova A, Scott G, et al., 2023, Visual atrophy rating scales and amyloid PET status in an Alzheimer's disease clinical cohort, Annals of Clinical and Translational Neurology, Vol:10, ISSN:2328-9503, Pages:619-631
Hoang K, Watt H, Golemme M, et al., 2022, Noradrenergic add-on therapy with extended-release guanfacine in alzheimer’s disease: study protocol for a randomised clinical trial (NorAD) and COVID-19 amendments, Trials, Vol:23, ISSN:1745-6215
David MCB, Del Giovane M, Liu KY, et al., 2022, Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease: systematic review and meta-analysis, Journal of Neurology Neurosurgery and Psychiatry, Vol:93, ISSN:0022-3050, Pages:1080-1090
Loreto F, Fitzgerald A, Golemme M, et al., 2022, Prevalence of depressive symptoms in a memory clinic cohort: a retrospective study, Journal of Alzheimers Disease, Vol:88, ISSN:1387-2877
Olgiati E, Malhotra P, 2022, Using non-invasive transcranial direct current stimulation for neglect and associated attentional deficits following stroke, Neuropsychological Rehabilitation, Vol:32, ISSN:0960-2011, Pages:732-763
Kolanko M, Loreto F, Win Z, et al., 2020, Amyloid PET imaging in clinical practice, Practical Neurology, Vol:20, ISSN:1474-7766, Pages:451-462
Li K, Bentley P, Nair A, et al., 2020, Reward sensitivity predicts dopaminergic response in spatial neglect, Cortex, Vol:122, ISSN:0010-9452, Pages:213-224
Malhotra P, 2019, Impairments of attention in Alzheimer’s disease, Current Opinion in Psychology, Vol:29, ISSN:2352-250X, Pages:41-48
Russell C, Davies S, Li K, et al., 2019, Self-perspective in episodic memory after parietal damage and in healthy ageing, Neuropsychologia, Vol:124, ISSN:0028-3932, Pages:171-181
Dalmaijer E, Li K, Gorgoraptis N, et al., 2018, A randomised double-blind, placebo-controlled crossover study of single-dose guanfacine in unilateral neglect following stroke, Journal of Neurology, Neurosurgery and Psychiatry, Vol:89, ISSN:1468-330X, Pages:593-598
Rinne P, Hassan M, Fernandes C, et al., 2018, Motor dexterity and strength depend upon integrity of the attention-control system, Proceedings of the National Academy of Sciences of the United States of America, Vol:115, ISSN:0027-8424, Pages:E536-E545
Malhotra PA, Russell C, 2015, Does stroke imaging provide insights into the neural basis of cognition?, Current Neurology and Neuroscience Reports, Vol:15, ISSN:1534-6293
Li K, Malhotra PA, 2015, Spatial Neglect, Practical Neurology, Vol:15, ISSN:1474-7766, Pages:333-339
Devine MJ, Bentley P, Jones B, et al., 2014, The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis, Journal of Neurology, Vol:261, ISSN:0340-5354, Pages:600-603
Chapters
Venkataraman A, Perry R, Malhotra P, Young Onset Dementia
Olgiati E, Russell C, Soto D, et al., 2016, Chapter 15 - Motivation and attention following hemispheric stroke, Progress in Brain Research, Editor(s): Studer, Knecht, ELSEVIER SCIENCE BV, Pages:343-366, ISBN:978-0-444-63701-7