Imperial College London
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ProfessorPareshMalhotra

Faculty of Medicine, Department of Brain Sciences

Professor of Clinical Neurology
 
 
 
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Contact

 

+44 (0)20 3313 5525p.malhotra

 
 
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Location

 

Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Newton:2023:10.1101/2023.01.31.526473,
author = {Newton, C and Pope, M and Rua, C and Henson, R and Ji, Z and Burgess, N and Rodgers, CT and Stangl, M and Dounavi, M-E and Castegnaro, A and Koychev, I and Malhotra, P and Wolbers, T and Ritchie, K and Ritchie, CW and O'Brien, J and Su, L and Chan, D and PREVENT, Dementia Research Programme},
doi = {10.1101/2023.01.31.526473},
journal = {bioRxiv},
title = {Path integration selectively predicts midlife risk of Alzheimer's disease.},
url = {http://dx.doi.org/10.1101/2023.01.31.526473},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration, we predicted that path integration impairment would represent the first behavioural change in adults at-risk of AD. Using immersive virtual reality, we found that midlife path integration impairments predicted both hereditary and physiological AD risk, with no corresponding impairment on tests of episodic memory or other spatial behaviours. Impairments related to poorer angular estimation and were associated with hexadirectional grid-like fMRI signal in the posterior-medial EC. These results indicate that altered path integration may represent the transition point from at-risk state to disease onset in AD, prior to impairment in other cognitive domains.
AU  - Newton,C
AU  - Pope,M
AU  - Rua,C
AU  - Henson,R
AU  - Ji,Z
AU  - Burgess,N
AU  - Rodgers,CT
AU  - Stangl,M
AU  - Dounavi,M-E
AU  - Castegnaro,A
AU  - Koychev,I
AU  - Malhotra,P
AU  - Wolbers,T
AU  - Ritchie,K
AU  - Ritchie,CW
AU  - O'Brien,J
AU  - Su,L
AU  - Chan,D
AU  - PREVENT,Dementia Research Programme
DO  - 10.1101/2023.01.31.526473
PY  - 2023///
TI  - Path integration selectively predicts midlife risk of Alzheimer's disease.
T2  - bioRxiv
UR  - http://dx.doi.org/10.1101/2023.01.31.526473
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36778428
ER  -
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