Patrick Mallia is a Senior Lecturer in Respiratory Medicine within the Respiratory Infections Section, National Heart and Lung Institute (NHLI), Imperial College London. He qualified in medicine from the University of Malta and following clinical training in Malta and the UK he joined Professor's Johnston's group as a PhD student. Following completion of his PhD he returned to full time clinical training then returned to Imperial College initially as a NIHR Clinical Lecturer and subsequently as Senior Lecturer. He developed a human model of COPD exacerbation using experimental rhinovirus infection in COPD patients, successfully demonstrating that this is a safe and valid model and providing novel insights into the mechanisms of virus-induced exacerbations. In addition he contributed to clinical and experimental studies in asthma. In addition he demonstrated that secondary bacterial infection is common following rhinovirus infection in COPD, and is related to deficiency of antimicrobial peptides. He is currently undertaking further studies into the role of viruses and bacteria in COPD exacerbations and the mechanisms of suceptibility to infection in COPD.
Cafferkey J, Coultas JA, Mallia P, 2020, Human rhinovirus infection and COPD: role in exacerbations and potential for therapeutic targets, Expert Review of Respiratory Medicine, ISSN:1747-6348
et al., 2020, Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD, Journal of Allergy and Clinical Immunology, ISSN:0091-6749
et al., 2020, Targeted retreatment of incompletely recovered COPD exacerbations with ciprofloxacin: a double-blind, randomised, placebo-controlled, multicentre phase III trial., American Journal of Respiratory and Critical Care Medicine, ISSN:1073-449X
et al., 2020, Epitope-specific airway-resident CD4+ T-cell dynamics during experimental human RSV infection, Journal of Clinical Investigation, Vol:130, ISSN:0021-9738, Pages:523-538
et al., 2019, Antiviral immunity is impaired in COPD patients with frequent exacerbations, American Journal of Physiology: Lung Cellular and Molecular Physiology, Vol:317, ISSN:1040-0605, Pages:L893-L903