Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

584 results found

Kineses ZT, Johansen-Berg H, Tomassini V, Bosnell R, Matthews PM, Beckmann CFet al., 2008, Model-free characterization of brain functional networks for motor sequence learning using fMRI, NEUROIMAGE, Vol: 39, Pages: 1950-1958, ISSN: 1053-8119

JOURNAL ARTICLE

Wegner C, Filippi M, Korteweg T, Beckmann C, Ciccarelli O, De Stefano N, Enzinger C, Fazekas F, Agosta F, Gass A, Hirsch J, Johansen-Berg H, Kappos L, Barkhof F, Polman C, Mancini L, Manfredonia F, Marino S, Miller DH, Montalban X, Palace J, Rocca M, Ropele S, Rovira A, Smith S, Thompson A, Thornton J, Yousry T, Matthews PMet al., 2008, Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 15, Pages: 113-122, ISSN: 1351-5101

JOURNAL ARTICLE

Giorgio A, Watkins KE, Douaud G, James AC, James S, De Stefano N, Matthews PM, Smith SM, Johansen-Berg Het al., 2008, Changes in white matter microstructure during adolescence, NEUROIMAGE, Vol: 39, Pages: 52-61, ISSN: 1053-8119

JOURNAL ARTICLE

Li H, Wetten S, Li L, Jean PLS, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung G-Y, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I, Matthews PM, Owen MJ, Plumpton M, Pryse-Phillips W, Prinjha RK, Richardson JC, Saunders A, Slater AJ, George-Hyslop PHS, Stinnett SW, Swartz JE, Taylor RL, Wherrett J, Williams J, Yarnall DP, Gibson RA, Irizarry MC, Middleton LT, Roses ADet al., 2008, Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease, ARCHIVES OF NEUROLOGY, Vol: 65, Pages: 45-53, ISSN: 0003-9942

JOURNAL ARTICLE

Li X-D, Luo W-J, Yao X, 2008, Preface, JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY, Vol: 23, Pages: 1-1, ISSN: 1000-9000

JOURNAL ARTICLE

David SP, Munafo MR, Johansen-Berg H, MacKillop J, Sweet LH, Cohen RA, Niaura R, Rogers RD, Matthews PM, Walton RTet al., 2007, Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study, BRAIN IMAGING AND BEHAVIOR, Vol: 1, Pages: 43-57, ISSN: 1931-7557

JOURNAL ARTICLE

De Stefano N, Filippi M, Miller D, Pouwels PJ, Rovira A, Gass A, Enzinger C, Matthews PM, Arnold DLet al., 2007, Guidelines for using proton MR spectroscopy in multicenter clinical MS studies, NEUROLOGY, Vol: 69, Pages: 1942-1952, ISSN: 0028-3878

JOURNAL ARTICLE

Blamire AM, Cader S, Lee M, Palace J, Matthews PMet al., 2007, Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy, MAGNETIC RESONANCE IN MEDICINE, Vol: 58, Pages: 880-885, ISSN: 0740-3194

JOURNAL ARTICLE

Tomassini V, Jbabdi S, Klein JC, Behrens TEJ, Pozzilli C, Matthews PM, Rushworth MFS, Johansen-Berg Het al., 2007, Diffusion-weighted Imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations, JOURNAL OF NEUROSCIENCE, Vol: 27, Pages: 10259-10269, ISSN: 0270-6474

JOURNAL ARTICLE

Tomassini V, Jbabdi S, Klein JC, Behrens TE, Rushworth M, Matthews PM, Palace J, Johansen-Berg Het al., 2007, Diffusion tensor imaging defines subregions of human lateral premotor cortex with distinct frontoparietal connections, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1028-1028, ISSN: 0022-3050

CONFERENCE PAPER

Stagg CJ, Kincses ZT, Palace J, Matthews PM, Johansen-Berg Het al., 2007, Transcranial direct current stimulation: A potential tool for rehabilitation?, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1036-1036, ISSN: 0022-3050

CONFERENCE PAPER

Douaud G, Smith S, Jenkinson M, Behrens T, Johansen-Berg H, Vickers J, James S, Voets N, Watkins K, Matthews PM, James Aet al., 2007, Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia, BRAIN, Vol: 130, Pages: 2375-2386, ISSN: 0006-8950

JOURNAL ARTICLE

Giorgio A, Watkins KE, Douaud G, Behrens TE, Matthews PM, James AC, James S, Smith SM, Johansen-Berg Het al., 2007, Developmental changes in white matter microstructure in adolescence, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1019-1020, ISSN: 0022-3050

CONFERENCE PAPER

Smith SM, Rao A, De Stefano N, Jenkinson M, Schott JM, Matthews PM, Fox NCet al., 2007, Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: Cross-validation of BSI, SIENA and SIENAX, NEUROIMAGE, Vol: 36, Pages: 1200-1206, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, 2007, Molecular imaging of brain amyloid in mild cognitive impairment and Alzheimer's disease, NATURE CLINICAL PRACTICE NEUROLOGY, Vol: 3, Pages: 366-367, ISSN: 1745-834X

JOURNAL ARTICLE

Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A, Matthews PM, Cowen PJet al., 2007, Reduction in occipital cortex GABA concentrations in medication free recovered bipolar subjects, International Conference on Bipolar Disorder, Publisher: BLACKWELL PUBLISHING, Pages: 21-21, ISSN: 1398-5647

CONFERENCE PAPER

Cader S, Johansen-Berg H, Wylezinska M, Palace I, Behrens TE, Smith S, Matthews PMet al., 2007, Discordant white matter N-acetylasparate and diffusion MRI measures suggest that chronic metabolic dysfunction contributes to axonal pathology in multiple sclerosis, NEUROIMAGE, Vol: 36, Pages: 19-27, ISSN: 1053-8119

JOURNAL ARTICLE

Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A, Matthews PM, Cowen PJet al., 2007, Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects, BIOLOGICAL PSYCHIATRY, Vol: 61, Pages: 806-812, ISSN: 0006-3223

JOURNAL ARTICLE

Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JTR, Bortolotto ZA, Wang YT, Collingridge GLet al., 2007, UP inhibits LTD in the hippocampus via regulation of GSK3 beta, NEURON, Vol: 53, Pages: 703-717, ISSN: 0896-6273

JOURNAL ARTICLE

Matthews PM, Talbot K, 2007, Magnetic resonance spectroscopic imaging - of prognostic value in amyotrophic lateral sclerosis?, NATURE CLINICAL PRACTICE NEUROLOGY, Vol: 3, Pages: 76-77, ISSN: 1745-834X

JOURNAL ARTICLE

Morgan RM, Parry AMM, Arida RM, Matthews PM, Davies B, Castell LMet al., 2007, Effects of elevated plasma tryptophan on brain activation associated with the Stroop task, PSYCHOPHARMACOLOGY, Vol: 190, Pages: 383-389, ISSN: 0033-3158

JOURNAL ARTICLE

Zarei M, Johansen-Berg H, Jenkinson M, Ciccarelli O, Thompson AJ, Matthews PMet al., 2007, Two-dimensional population map of cortical connections in the human internal capsule, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 25, Pages: 48-54, ISSN: 1053-1807

JOURNAL ARTICLE

Schloesser RGM, Nenadic I, Wagner G, Guellmar D, von Consbruch K, Koehler S, Schultz CC, Koch K, Fitzek C, Matthews PM, Reichenbach JR, Sauer Het al., 2007, White matter abnormalities and brain activation in schizophrenia: A combined DTI and fMRI study, SCHIZOPHRENIA RESEARCH, Vol: 89, Pages: 1-11, ISSN: 0920-9964

JOURNAL ARTICLE

Enzinger C, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt Ret al., 2006, Factors associated with progression of brain atrophy during ageing: 6 year follow-up from the Austrian stroke prevention study, Research and Practice in Alzheimer's Disease, Vol: 11, Pages: 227-233, ISSN: 1284-8360

Neuroimaging techniques are increasingly used to study mechanisms leading to cognitive impairment. In particular, brain atrophy has been proposed as a surrogate marker of dementia. However, little is known regarding confounding factors which might modulate the evolution of brain atrophy during ageing. We therefore determined the rate of atrophy over 6 years for 201 participants (F/M=96/105; 59.8±5.9 yrs) in the Austrian Stroke Prevention Study and probed the impact of baseline variables on its progression. The mean annual brain volume change was -0.40±0.29%. The rate of brain atrophy was significantly higher in subjects of greater age and those with higher HbA1c, higher body-mass-index, high alcohol intake, severe white matter hyperintensities, and in APOEε4-carriers. Multivariate analysis suggested that baseline brain volume, HbA1cand the extent of white matter hyperintensities explain a major proportion of variance in the rates of brain atrophy. These results indicate that neurologically asymptomatic elderly experience continuing brain volume loss, which appears to accelerate with age. HbA1cwas identified as a risk factor for a greater rate of brain atrophy. Clustering of factors associated with the so-called "metabolic syndrome" in subjects with high HbA1csuggests a link between this syndrome and late-life brain tissue loss. Together, this underscores the need to control for confounding factors in future Clinical trials and indicates possible new directions for intervention.

JOURNAL ARTICLE

Pomeroy IM, Jordan EK, Frank J, Matthews PM, Esiri MMet al., 2006, Neurodegeneration in a marmoset model of multiple sclerosis, Spring Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 1399-1399, ISSN: 0022-3050

CONFERENCE PAPER

Abu-Omar Y, Cader S, Wolf LG, Pigott D, Matthews PM, Taggart DPet al., 2006, Short-term changes in cerebral activity in on-pump and off-pump cardiac surgery defined by functional magnetic resonance imaging and their relationship to microembolization, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 132, Pages: 1119-1125, ISSN: 0022-5223

JOURNAL ARTICLE

Manson SC, Palace J, Frank JA, Matthews PMet al., 2006, Loss of interhemispheric inhibition in patients with multiple sclerosis is related to corpus callosum atrophy, EXPERIMENTAL BRAIN RESEARCH, Vol: 174, Pages: 728-733, ISSN: 0014-4819

JOURNAL ARTICLE

Wegner C, Esiri MM, Chance SA, Palace J, Matthews PMet al., 2006, Neocortical neuronal, synaptic, and glial loss in multiple sclerosis, NEUROLOGY, Vol: 67, Pages: 960-967, ISSN: 0028-3878

JOURNAL ARTICLE

Zarei M, Johansen-Berg H, Smith S, Ciccarelli O, Thompson AJ, Matthews PMet al., 2006, Functional anatomy of interhemispheric cortical connections in the human brain, JOURNAL OF ANATOMY, Vol: 209, Pages: 311-320, ISSN: 0021-8782

JOURNAL ARTICLE

Matthews PM, Honey GD, Bullmore ET, 2006, Applications of fMRI in translational medicine and clinical practice, NATURE REVIEWS NEUROSCIENCE, Vol: 7, Pages: 732-744, ISSN: 1471-0048

JOURNAL ARTICLE

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