Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

577 results found

Blamire AM, Cader S, Lee M, Palace J, Matthews PMet al., 2007, Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy, MAGNETIC RESONANCE IN MEDICINE, Vol: 58, Pages: 880-885, ISSN: 0740-3194

JOURNAL ARTICLE

Tomassini V, Jbabdi S, Klein JC, Behrens TEJ, Pozzilli C, Matthews PM, Rushworth MFS, Johansen-Berg Het al., 2007, Diffusion-weighted Imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations, JOURNAL OF NEUROSCIENCE, Vol: 27, Pages: 10259-10269, ISSN: 0270-6474

JOURNAL ARTICLE

Giorgio A, Watkins KE, Douaud G, Behrens TE, Matthews PM, James AC, James S, Smith SM, Johansen-Berg Het al., 2007, Developmental changes in white matter microstructure in adolescence, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1019-1020, ISSN: 0022-3050

CONFERENCE PAPER

Stagg CJ, Kincses ZT, Palace J, Matthews PM, Johansen-Berg Het al., 2007, Transcranial direct current stimulation: A potential tool for rehabilitation?, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1036-1036, ISSN: 0022-3050

CONFERENCE PAPER

Douaud G, Smith S, Jenkinson M, Behrens T, Johansen-Berg H, Vickers J, James S, Voets N, Watkins K, Matthews PM, James Aet al., 2007, Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia, BRAIN, Vol: 130, Pages: 2375-2386, ISSN: 0006-8950

JOURNAL ARTICLE

Tomassini V, Jbabdi S, Klein JC, Behrens TE, Rushworth M, Matthews PM, Palace J, Johansen-Berg Het al., 2007, Diffusion tensor imaging defines subregions of human lateral premotor cortex with distinct frontoparietal connections, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1028-1028, ISSN: 0022-3050

CONFERENCE PAPER

Smith SM, Rao A, De Stefano N, Jenkinson M, Schott JM, Matthews PM, Fox NCet al., 2007, Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: Cross-validation of BSI, SIENA and SIENAX, NEUROIMAGE, Vol: 36, Pages: 1200-1206, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, 2007, Molecular imaging of brain amyloid in mild cognitive impairment and Alzheimer's disease, NATURE CLINICAL PRACTICE NEUROLOGY, Vol: 3, Pages: 366-367, ISSN: 1745-834X

JOURNAL ARTICLE

Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A, Matthews PM, Cowen PJet al., 2007, Reduction in occipital cortex GABA concentrations in medication free recovered bipolar subjects, International Conference on Bipolar Disorder, Publisher: BLACKWELL PUBLISHING, Pages: 21-21, ISSN: 1398-5647

CONFERENCE PAPER

Cader S, Johansen-Berg H, Wylezinska M, Palace I, Behrens TE, Smith S, Matthews PMet al., 2007, Discordant white matter N-acetylasparate and diffusion MRI measures suggest that chronic metabolic dysfunction contributes to axonal pathology in multiple sclerosis, NEUROIMAGE, Vol: 36, Pages: 19-27, ISSN: 1053-8119

JOURNAL ARTICLE

Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A, Matthews PM, Cowen PJet al., 2007, Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects, BIOLOGICAL PSYCHIATRY, Vol: 61, Pages: 806-812, ISSN: 0006-3223

JOURNAL ARTICLE

Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JTR, Bortolotto ZA, Wang YT, Collingridge GLet al., 2007, UP inhibits LTD in the hippocampus via regulation of GSK3 beta, NEURON, Vol: 53, Pages: 703-717, ISSN: 0896-6273

JOURNAL ARTICLE

Matthews PM, Talbot K, 2007, Magnetic resonance spectroscopic imaging - of prognostic value in amyotrophic lateral sclerosis?, NATURE CLINICAL PRACTICE NEUROLOGY, Vol: 3, Pages: 76-77, ISSN: 1745-834X

JOURNAL ARTICLE

Morgan RM, Parry AMM, Arida RM, Matthews PM, Davies B, Castell LMet al., 2007, Effects of elevated plasma tryptophan on brain activation associated with the Stroop task, PSYCHOPHARMACOLOGY, Vol: 190, Pages: 383-389, ISSN: 0033-3158

JOURNAL ARTICLE

Zarei M, Johansen-Berg H, Jenkinson M, Ciccarelli O, Thompson AJ, Matthews PMet al., 2007, Two-dimensional population map of cortical connections in the human internal capsule, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 25, Pages: 48-54, ISSN: 1053-1807

JOURNAL ARTICLE

Schloesser RGM, Nenadic I, Wagner G, Guellmar D, von Consbruch K, Koehler S, Schultz CC, Koch K, Fitzek C, Matthews PM, Reichenbach JR, Sauer Het al., 2007, White matter abnormalities and brain activation in schizophrenia: A combined DTI and fMRI study, SCHIZOPHRENIA RESEARCH, Vol: 89, Pages: 1-11, ISSN: 0920-9964

JOURNAL ARTICLE

Pomeroy IM, Jordan EK, Frank J, Matthews PM, Esiri MMet al., 2006, Neurodegeneration in a marmoset model of multiple sclerosis, Spring Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 1399-1399, ISSN: 0022-3050

CONFERENCE PAPER

Ropele S, Schmidt H, Smith S, Schmidt Ret al., 2006, Factors associated with progression of brain atrophy during ageing: 6 year follow-up from the Austrian stroke prevention study, Research and Practice in Alzheimer's Disease, Vol: 11, Pages: 227-233, ISSN: 1284-8360

Neuroimaging techniques are increasingly used to study mechanisms leading to cognitive impairment. In particular, brain atrophy has been proposed as a surrogate marker of dementia. However, little is known regarding confounding factors which might modulate the evolution of brain atrophy during ageing. We therefore determined the rate of atrophy over 6 years for 201 participants (F/M=96/105; 59.8±5.9 yrs) in the Austrian Stroke Prevention Study and probed the impact of baseline variables on its progression. The mean annual brain volume change was -0.40±0.29%. The rate of brain atrophy was significantly higher in subjects of greater age and those with higher HbA1c, higher body-mass-index, high alcohol intake, severe white matter hyperintensities, and in APOEε4-carriers. Multivariate analysis suggested that baseline brain volume, HbA1cand the extent of white matter hyperintensities explain a major proportion of variance in the rates of brain atrophy. These results indicate that neurologically asymptomatic elderly experience continuing brain volume loss, which appears to accelerate with age. HbA1cwas identified as a risk factor for a greater rate of brain atrophy. Clustering of factors associated with the so-called "metabolic syndrome" in subjects with high HbA1csuggests a link between this syndrome and late-life brain tissue loss. Together, this underscores the need to control for confounding factors in future Clinical trials and indicates possible new directions for intervention.

JOURNAL ARTICLE

Abu-Omar Y, Cader S, Wolf LG, Pigott D, Matthews PM, Taggart DPet al., 2006, Short-term changes in cerebral activity in on-pump and off-pump cardiac surgery defined by functional magnetic resonance imaging and their relationship to microembolization, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 132, Pages: 1119-1125, ISSN: 0022-5223

JOURNAL ARTICLE

Manson SC, Palace J, Frank JA, Matthews PMet al., 2006, Loss of interhemispheric inhibition in patients with multiple sclerosis is related to corpus callosum atrophy, EXPERIMENTAL BRAIN RESEARCH, Vol: 174, Pages: 728-733, ISSN: 0014-4819

JOURNAL ARTICLE

Wegner C, Esiri MM, Chance SA, Palace J, Matthews PMet al., 2006, Neocortical neuronal, synaptic, and glial loss in multiple sclerosis, NEUROLOGY, Vol: 67, Pages: 960-967, ISSN: 0028-3878

JOURNAL ARTICLE

Matthews PM, Honey GD, Bullmore ET, 2006, Applications of fMRI in translational medicine and clinical practice, NATURE REVIEWS NEUROSCIENCE, Vol: 7, Pages: 732-744, ISSN: 1471-0048

JOURNAL ARTICLE

Jamison HL, Watkins KE, Bishop DVM, Matthews PMet al., 2006, Hemispheric specialization for processing auditory nonspeech stimuli, CEREBRAL CORTEX, Vol: 16, Pages: 1266-1275, ISSN: 1047-3211

JOURNAL ARTICLE

Zarei M, Johansen-Berg H, Smith S, Ciccarelli O, Thompson AJ, Matthews PMet al., 2006, Functional anatomy of interhemispheric cortical connections in the human brain, JOURNAL OF ANATOMY, Vol: 209, Pages: 311-320, ISSN: 0021-8782

JOURNAL ARTICLE

Farrugia ME, Robson MD, Kennett RP, Matthews PM, Anslow P, Hilton-Jones D, Newsom-Davis J, Vincent Aet al., 2006, Facial muscle atrophy in musk antibody positive myasthenia gravis, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 13, Pages: 23-23, ISSN: 1351-5101

JOURNAL ARTICLE

, 2006, Noninvasive brain imaging for experimental medicine in drug discovery and development: Promise and pitfalls, International Journal of Pharmaceutical Medicine, Vol: 20, Pages: 167-175, ISSN: 1364-9027

There is currently increased focus on experimental medicine in drug development. Imaging methods potentially provide highly cost-effective, general approaches for the noninvasive characterisation of disease and pharmacokinetics, pharmacodynamics and drug effects directly in humans in ways that can enable this. The two methods most widely employed now are positron emission tomography (PET) and magnetic resonance imaging (MRI). PET allows the distribution of radiolabelled molecules to be mapped, enabling studies of molecule distribution and tissue metabolism. MRI was initially used primarily to define tissue structure, but a more recent range of functional MRI techniques promise the potential to define pharmacokinetic data over biologically meaningful timescales. With an understanding of the relationship between imaging biomarker changes and clinical outcomes, imaging can be used as a surrogate marker of response even for the later stages of drug development. There are pitfalls in the application of these methods, which need to be avoided. The two most common are: (i) getting distracted by the technology rather than focusing on the questions that need to be asked; and (ii) the failure to interpret the imaging data in an appropriate disease- and drug-specific fashion. However, with attention to such issues, imaging should prove a powerful facilitating platform for experimental medicine in the future. © 2006 Adis Data Information BV. All rights reserved.

JOURNAL ARTICLE

Enzinger C, Smith S, Fazekas F, Drevin G, Ropele S, Nichols T, Behrens T, Schmidt R, Matthews PMet al., 2006, Lesion probability maps of white matter hyperintensities in elderly individuals - Results of the Austrian stroke prevention study, JOURNAL OF NEUROLOGY, Vol: 253, Pages: 1064-1070, ISSN: 0340-5354

JOURNAL ARTICLE

Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, Watkins KE, Ciccarelli O, Cader MZ, Matthews PM, Behrens TEJet al., 2006, Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data, NEUROIMAGE, Vol: 31, Pages: 1487-1505, ISSN: 1053-8119

JOURNAL ARTICLE

Ciccarelli O, Behrens TE, Altmann DR, Orrell RW, Howard RS, Johansen-Berg H, Miller DH, Matthews PM, Thompson AJet al., 2006, Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis, BRAIN, Vol: 129, Pages: 1859-1871, ISSN: 0006-8950

JOURNAL ARTICLE

Selvaraj S, Wylezinska M, Evans J, Jezzard P, Matthews PM, Cowen PJet al., 2006, Tryptophan depletion does not lower brain GABA levels in healthy volunteers, PSYCHOPHARMACOLOGY, Vol: 187, Pages: 131-132, ISSN: 0033-3158

JOURNAL ARTICLE

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