Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

584 results found

Farrugia ME, Robson MD, Kennett RP, Matthews PM, Anslow P, Hilton-Jones D, Newsom-Davis J, Vincent Aet al., 2006, Facial muscle atrophy in musk antibody positive myasthenia gravis, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 13, Pages: 23-23, ISSN: 1351-5101

JOURNAL ARTICLE

Jamison HL, Watkins KE, Bishop DVM, Matthews PMet al., 2006, Hemispheric specialization for processing auditory nonspeech stimuli, CEREBRAL CORTEX, Vol: 16, Pages: 1266-1275, ISSN: 1047-3211

JOURNAL ARTICLE

Whitcher B, Matthews PM, 2006, Noninvasive brain imaging for experimental medicine in drug discovery and development: Promise and pitfalls, International Journal of Pharmaceutical Medicine, Vol: 20, Pages: 167-175, ISSN: 1364-9027

There is currently increased focus on experimental medicine in drug development. Imaging methods potentially provide highly cost-effective, general approaches for the noninvasive characterisation of disease and pharmacokinetics, pharmacodynamics and drug effects directly in humans in ways that can enable this. The two methods most widely employed now are positron emission tomography (PET) and magnetic resonance imaging (MRI). PET allows the distribution of radiolabelled molecules to be mapped, enabling studies of molecule distribution and tissue metabolism. MRI was initially used primarily to define tissue structure, but a more recent range of functional MRI techniques promise the potential to define pharmacokinetic data over biologically meaningful timescales. With an understanding of the relationship between imaging biomarker changes and clinical outcomes, imaging can be used as a surrogate marker of response even for the later stages of drug development. There are pitfalls in the application of these methods, which need to be avoided. The two most common are: (i) getting distracted by the technology rather than focusing on the questions that need to be asked; and (ii) the failure to interpret the imaging data in an appropriate disease- and drug-specific fashion. However, with attention to such issues, imaging should prove a powerful facilitating platform for experimental medicine in the future. © 2006 Adis Data Information BV. All rights reserved.

JOURNAL ARTICLE

Enzinger C, Smith S, Fazekas F, Drevin G, Ropele S, Nichols T, Behrens T, Schmidt R, Matthews PMet al., 2006, Lesion probability maps of white matter hyperintensities in elderly individuals - Results of the Austrian stroke prevention study, JOURNAL OF NEUROLOGY, Vol: 253, Pages: 1064-1070, ISSN: 0340-5354

JOURNAL ARTICLE

Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, Watkins KE, Ciccarelli O, Cader MZ, Matthews PM, Behrens TEJet al., 2006, Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data, NEUROIMAGE, Vol: 31, Pages: 1487-1505, ISSN: 1053-8119

JOURNAL ARTICLE

Ciccarelli O, Behrens TE, Altmann DR, Orrell RW, Howard RS, Johansen-Berg H, Miller DH, Matthews PM, Thompson AJet al., 2006, Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis, BRAIN, Vol: 129, Pages: 1859-1871, ISSN: 0006-8950

JOURNAL ARTICLE

Ciccarelli O, Toosy AT, Marsden JE, Wheeler-Kingshott CM, Miller DH, Matthews PM, Thompson AJet al., 2006, Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis, JOURNAL OF NEUROLOGY, Vol: 253, Pages: 882-891, ISSN: 0340-5354

JOURNAL ARTICLE

Selvaraj S, Wylezinska M, Evans J, Jezzard P, Matthews PM, Cowen PJet al., 2006, Tryptophan depletion does not lower brain GABA levels in healthy volunteers, PSYCHOPHARMACOLOGY, Vol: 187, Pages: 131-132, ISSN: 0033-3158

JOURNAL ARTICLE

Matthews PM, Wise RG, 2006, Noninvasive brain imaging for experimental medicine in drug discovery, EXPERT OPINION ON DRUG DISCOVERY, Vol: 1, Pages: 111-121, ISSN: 1746-0441

JOURNAL ARTICLE

Devlin JT, Jamison HL, Gonnerman LM, Matthews PMet al., 2006, The role of the posterior fusiform gyrus in reading, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 18, Pages: 911-922, ISSN: 0898-929X

JOURNAL ARTICLE

Ramnani N, Behrens TEJ, Johansen-Berg H, Richter MC, Pinsk MA, Andersson JLR, Rudebeck P, Ciccarelli O, Richter W, Thompson AJ, Gross CG, Robson MD, Kastner S, Matthews PMet al., 2006, The evolution of prefrontal inputs to the cortico-pontine system: Diffusion imaging evidence from macaque monkeys and humans, CEREBRAL CORTEX, Vol: 16, Pages: 811-818, ISSN: 1047-3211

JOURNAL ARTICLE

Farrugia ME, Robson MD, Clover L, Anslow P, Newsom-Davis J, Kennett R, Hilton-Jones D, Matthews PM, Vincent Aet al., 2006, MRI and clinical studies of facial and bulbar muscle involvement in MUSK antibody-associated myasthenia gravis, BRAIN, Vol: 129, Pages: 1481-1492, ISSN: 0006-8950

JOURNAL ARTICLE

Devlin JT, Sillery EL, Hall DA, Hobden P, Behrens TEJ, Nunes RG, Clare S, Matthews PM, Moore DR, Johansen-Berg Het al., 2006, Reliable identification of the auditory thalamus using multi-modal structural analyses, NEUROIMAGE, Vol: 30, Pages: 1112-1120, ISSN: 1053-8119

JOURNAL ARTICLE

Mottonen R, Calvert GA, Jaaskelainen IP, Matthews PM, Thesen T, Tuomainen J, Sams Met al., 2006, Perceiving identical sounds as speech or non-speech modulates activity in the left posterior superior temporal sulcus, NEUROIMAGE, Vol: 30, Pages: 563-569, ISSN: 1053-8119

JOURNAL ARTICLE

Korteweg T, Tintore M, Uitdehoog B, Rovira A, Frederiksen J, Miller D, Fernando K, Filippi M, Agosta F, Rocca M, Fazekas F, Enzinger C, Matthews P, Parry A, Polman C, Montalban X, Barkhof Fet al., 2006, MRI criteria for dissemination in space in patients with clinically isolated syndromes: a multicentre follow-up study, LANCET NEUROLOGY, Vol: 5, Pages: 221-227, ISSN: 1474-4422

JOURNAL ARTICLE

Voets NL, Adcock JE, Flitney DE, Behrens TEJ, Hart Y, Stacey R, Carpenter K, Matthews PMet al., 2006, Distinct right frontal lobe activation in language processing following left hemisphere injury, BRAIN, Vol: 129, Pages: 754-766, ISSN: 0006-8950

JOURNAL ARTICLE

Floyer-Lea A, Wylezinska M, Kincses T, Matthews PMet al., 2006, Rapid modulation of GABA concentration in human sensorimotor cortex during motor learning, JOURNAL OF NEUROPHYSIOLOGY, Vol: 95, Pages: 1639-1644, ISSN: 0022-3077

JOURNAL ARTICLE

De Luca M, Beckmann CF, De Stefano N, Matthews PM, Smith SMet al., 2006, fMRI resting state networks define distinct modes of long-distance interactions in the human brain, NEUROIMAGE, Vol: 29, Pages: 1359-1367, ISSN: 1053-8119

JOURNAL ARTICLE

Cader S, Cifelli A, Abu-Omar Y, Palace J, Matthews PMet al., 2006, Reduced brain functional reserve and altered functional connectivity in patients with multiple sclerosis, BRAIN, Vol: 129, Pages: 527-537, ISSN: 0006-8950

JOURNAL ARTICLE

Burke G, Manson S, Figueiredo P, Davies N, Palace JA, Matthews PMet al., 2006, Effect of sildenafil citrate (Viagra) on cerebral blood flow in patients with multiple sclerosis, Clinical Neurosciences 2005 Meeting, Publisher: B M J PUBLISHING GROUP, Pages: 130-130, ISSN: 0022-3050

CONFERENCE PAPER

Matthews PM, Jezzard P, 2006, Functional magnetic resonance imaging, Neuroscience for Neurologists, Pages: 401-422, ISBN: 9781860946578

BOOK CHAPTER

Nenadic I, Schlosser R, Wagner G, Behrens T, Von Consbruch K, Schultz CC, Koch K, Kohler S, Gullmar D, Fitzek C, Reichenbach JR, Matthews PM, Sauer Het al., 2006, Combined imaging of white matter and brain activation in schizophrenia with DTI and fMRI: Evidence for temporolimbic and prefrontal alterations, 13th Biennial Winter Workshop on Schizophrenia Research, Publisher: ELSEVIER SCIENCE BV, Pages: 150-151, ISSN: 0920-9964

CONFERENCE PAPER

Matthews PM, 2005, Functional Brain Reorganization and Recovery After Injury to White Matter, Multiple Sclerosis as A Neuronal Disease, Pages: 451-466, ISBN: 9780127387611

This chapter discusses functional brain reorganization and recovery after injury to white matter. It primarily focuses on motor recovery. The brain has a limited repertoire of responses to brain injury. Three general mechanisms for recovery can be defined: (1) repair; (2) compensation; and (3) adaptation. The relative contributions of these different mechanisms to recovery change with the nature of the pathology and its context. Motor learning by the healthy brain provides a basis for understanding adaptive functional reorganization of the brain after injury. A number of special mechanisms may alter the potential for functional reorganization in the context of brain injury. Studies in the healthy brain suggest that functional reorganization in motor cortex could be strongly affected by γ-aminobutyric acid activity, as well as the excitatory glutaminergic system acting through N-methy D-aspartate (NMDA) receptors. Adaptive functional reorganization is an example of the more general phenomenon of "plasticity." Postinjury reorganization depends to a significant extent on modifications to existing pathways rather than the development of entirely new circuits that may be used to only a minor extent by the healthy brain or only under different conditions. A potentially important brain region mediating recovery is the cerebellum. The cerebellum has a well-described and key role in functional plasticity of the motor system during skill learning by the healthy brain. Cerebellar pathways have been implicated in circuitry mediating recovery and could be particularly important for adaptive responses to injury because of their high intrinsic synaptic plasticity. © 2005 Elsevier Inc. All rights reserved.

BOOK CHAPTER

De Luca M, Smith S, De Stefano N, Federico A, Matthews PMet al., 2005, Blood oxygenation level dependent contrast resting state networks are relevant to functional activity in the neocortical sensorimotor system, EXPERIMENTAL BRAIN RESEARCH, Vol: 167, Pages: 587-594, ISSN: 0014-4819

JOURNAL ARTICLE

Basoah A, Matthews PM, Morten KJ, 2005, Rapid rates of newly synthesized mitochondrial protein degradation are significantly affected by the generation of mitochondrial free radicals, FEBS LETTERS, Vol: 579, Pages: 6511-6517, ISSN: 1873-3468

JOURNAL ARTICLE

Iannetti GD, Niazy RK, Wise RG, Jezzard P, Brooks JCW, Zambreanu L, Vennart W, Matthews PM, Tracey Iet al., 2005, Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans, NEUROIMAGE, Vol: 28, Pages: 708-719, ISSN: 1053-8119

JOURNAL ARTICLE

Pomeroy IM, Matthews PM, Frank JA, Jordan EK, Esiri MMet al., 2005, Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis, BRAIN, Vol: 128, Pages: 2713-2721, ISSN: 0006-8950

JOURNAL ARTICLE

Schmidt R, Ropele S, Enzinger C, Petrovic K, Smith S, Schmidt H, Matthews PM, Fazekas Fet al., 2005, White matter lesion progression, brain atrophy, and cognitive decline: The Austrian Stroke Prevention Study, ANNALS OF NEUROLOGY, Vol: 58, Pages: 610-616, ISSN: 0364-5134

JOURNAL ARTICLE

David SP, Munafo MR, Johansen-Berg H, Smith SM, Rogers RD, Matthews PM, Walton RTet al., 2005, Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: A functional magnetic resonance imaging study, BIOLOGICAL PSYCHIATRY, Vol: 58, Pages: 488-494, ISSN: 0006-3223

JOURNAL ARTICLE

Manson SC, Burke G, Voets N, Palace J, Matthews PMet al., 2005, Effect of sildenafil citrate on CBF and BOLD activation in multiple sclerosis patients, 21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS, Publisher: HODDER ARNOLD, HODDER HEADLINE PLC, Pages: S59-S59, ISSN: 1352-4585

CONFERENCE PAPER

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