Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

584 results found

Burke G, Cavey A, Matthews PM, Palace JAet al., 2005, The evaluation of a novel "goat serum" therapy (Aimspro) in multiple sclerosis, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 1326-1326, ISSN: 0022-3050

CONFERENCE PAPER

Ciccarelli O, Toosy AT, Marsden JF, Wheeler-Kingshott CM, Sahyoun C, Matthews PM, Miller DH, Thompson AJet al., 2005, Identifying brain regions for integrative sensorimotor processing with ankle movements, EXPERIMENTAL BRAIN RESEARCH, Vol: 166, Pages: 31-42, ISSN: 0014-4819

JOURNAL ARTICLE

Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A, Matthews PM, Cowen PJet al., 2005, Cortical GABA levels and vulnerability to affective disorders, Summer Meeting of the British-Association-for-Psychoparmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A6-A6, ISSN: 0269-8811

CONFERENCE PAPER

Korteweg T, Tintore M, Uitdehaag BMJ, Rovira A, Montalban X, Miller DH, Fernando KTM, Filippi M, Agosta F, Fazekas F, Enzinger C, Matthews PM, Parry AMM, Polman CH, Barkhof Fet al., 2005, MRI criteria for diagnosing MS in patients with a clinically isolated syndrome, 21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS, Publisher: HODDER ARNOLD, HODDER HEADLINE PLC, Pages: S22-S22, ISSN: 1352-4585

CONFERENCE PAPER

Pomeroy IM, Matthews PM, Frank J, Jordan EK, Esiri MMet al., 2005, Decreased neuronal density within cortical lesions in an animal model of multiple sclerosis, 21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS, Publisher: HODDER ARNOLD, HODDER HEADLINE PLC, Pages: S44-S44, ISSN: 1352-4585

CONFERENCE PAPER

Tjandra T, Brooks JCW, Figueiredo P, Wise R, Matthews PM, Tracey Iet al., 2005, Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: Implications for clinical trial design, NEUROIMAGE, Vol: 27, Pages: 393-401, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, 2005, Brain plasticity and clinical applications of fMRI, RIVISTA DI NEURORADIOLOGIA, Vol: 18, Pages: 493-501, ISSN: 1120-9976

JOURNAL ARTICLE

Floyer-Lea A, Matthews PM, 2005, Distinguishable brain activation networks for short- and long-term motor skill learning, JOURNAL OF NEUROPHYSIOLOGY, Vol: 94, Pages: 512-518, ISSN: 0022-3077

JOURNAL ARTICLE

Osterbauer RA, Matthews PM, Jenkinson M, Beckmann CF, Hansen PC, Calvert GAet al., 2005, Color of scents: Chromatic stimuli modulate odor responses in the human brain, JOURNAL OF NEUROPHYSIOLOGY, Vol: 93, Pages: 3434-3441, ISSN: 0022-3077

JOURNAL ARTICLE

Enzinger C, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt Ret al., 2005, Risk factors for progression of brain atrophy in aging - Six-year follow-up of normal subjects, 14th Meeting of the European-Neurological-Society, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1704-1711, ISSN: 0028-3878

CONFERENCE PAPER

Motallebzadeh R, Jahangiri M, 2005, Distinguishing solid from gaseous emboli during cardiac surgery, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 129, Pages: 1194-1194, ISSN: 0022-5223

JOURNAL ARTICLE

Abu-Omar Y, Matthews PM, Taggart DP, 2005, Distinguishing solid from gaseous emboli during cardiac surgery - Reply, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 129, Pages: 1194-1195, ISSN: 0022-5223

JOURNAL ARTICLE

Zarei M, Johansen-Berg J, Ramnani N, Matthews PMet al., 2005, In vivo mapping of cortical connections in the human internal capsule and its implication in functional recovery after stroke, Sino-British Joint Conference on Neurology, Publisher: B M J PUBLISHING GROUP, Pages: 605-605, ISSN: 0022-3050

CONFERENCE PAPER

Smith SM, Beckmann CF, Ramnani N, Woolrich MW, Bannister PR, Jenkinson M, Matthews PM, McGonigle DJet al., 2005, Variability in fMRI: A re-examination of inter-session differences, HUMAN BRAIN MAPPING, Vol: 24, Pages: 248-257, ISSN: 1065-9471

JOURNAL ARTICLE

Voets NL, Matthews PM, 2005, Clinical applications of functional magnetic resonance imaging, Imaging Decisions MRI, Vol: 9, Pages: 16-22, ISSN: 1433-3317

Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) provides a new tool for neuroradiology. The BOLD fMRI allows functional changes to be distinguished, even in the absence of structural changes in the brain. Up until now, routine clinical applications largely have been limited to localizing eloquent brain regions in pre-surgical planning. However, in exploratory applications, the method has allowed new insights into mechanisms of brain plasticity, helping clinicians better appreciate its importance in recovery after brain injury. Several new areas of application may be anticipated based on current research work, including for pre-symptomatic disease detection, testing drug dose-activity relationships, and the diagnosis and characterization of somatization disorders. A major direction of methodological research is towards integration of fMRI with other techniques, particularly electrophysiological methods. The emphasis that these new approaches to imaging will place on understanding functional changes associated with disease challenges current neuroradiological training and service delivery models. They emphasize the need to develop closer relationship between neuroradiology and the traditional clinical neurosciences.

JOURNAL ARTICLE

Austin VC, Blamire AM, Allers KA, Sharp T, Styles P, Matthews PM, Sibson NRet al., 2005, Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia, NEUROIMAGE, Vol: 24, Pages: 92-100, ISSN: 1053-8119

JOURNAL ARTICLE

Olivers CNL, Smith S, Matthews P, Humphreys GWet al., 2005, Prioritizing new over old: An fMRI study of the preview search task, HUMAN BRAIN MAPPING, Vol: 24, Pages: 69-78, ISSN: 1065-9471

JOURNAL ARTICLE

Wegner C, Esiri MM, Palace J, Matthews PMet al., 2005, Synaptic loss and impaired synaptic plasticity in cortical lesions of multiple sclerosis, Autumn Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 152-152, ISSN: 0022-3050

CONFERENCE PAPER

Johansen-Berg H, Behrens TEJ, Sillery E, Ciccarelli O, Thompson AJ, Smith SM, Matthews PMet al., 2005, Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus, CEREBRAL CORTEX, Vol: 15, Pages: 31-39, ISSN: 1047-3211

JOURNAL ARTICLE

Devlin JT, Rushworth MFS, Matthews PM, 2005, Category-related activation for written words in the posterior fusiform is task specific, NEUROPSYCHOLOGIA, Vol: 43, Pages: 69-74, ISSN: 0028-3932

JOURNAL ARTICLE

Devlin JT, Watkins KE, Sillery EL, Behrens TEJ, Johansen-Berg H, Nunes RG, Clare S, Matthews PMet al., 2005, Distinct fronto-temporal pathways mediate semantic and phonological processing, 12th Annnual Meeting of the Cognitive-Neuroscience-Society, Publisher: M I T PRESS, Pages: 43-43, ISSN: 0898-929X

CONFERENCE PAPER

Bridge H, Clare S, Jenkinson M, Jezzard P, Parker AJ, Matthews PMet al., 2005, Independent anatomical and functional measures of the V1/V2 boundary in human visual cortex, JOURNAL OF VISION, Vol: 5, Pages: 93-102, ISSN: 1534-7362

JOURNAL ARTICLE

Pomeroy IM, Esiri MM, Matthews PM, Palace Jet al., 2005, Typical cortical lesions in an animal model of MS, Autumn Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 152-152, ISSN: 0022-3050

CONFERENCE PAPER

Matthews PM, Johansen-Berg H, Reddy H, 2004, Non-invasive mapping of brain functions and brain recovery: Applying lessons from cognitive neuroscience to neurorehabilitation, Restorative Neurology and Neuroscience, Vol: 22, Pages: 245-260, ISSN: 0922-6028

Modern cognitive neuroscience provides a powerful framework in which biological models of recovery and neurorehabilitation can be constructed and tested. The widespread availability, relatively low cost and informativeness of functional magnetic resonance imaging (fMRI) has made it the most popular of the techniques available to help with this task. Here, on the basis of functional imaging studies of stroke, diffuse microvascular disease and multiple sclerosis, we argue that processes of motor control and learning in the healthy brain share common mechanisms with those for adaptive functional reorganisation during spontaneous recovery after brain injury or with neurorehabilitation. Relatively stringent criteria can be met to confirm that adaptive functional reorganisation limits disability even in the adult brain: functional brain changes are related to disease burden, can be found in patients with demonstrable pathology but no clinical deficits and can be defined (in motor cortex) even in the absence of volitional recruitment. Initial studies of neurorehabilitation responses using fMRI and transcranial magnetic stimulation demonstrate that adaptive reorganisation can be manipulated directly with both pharmacological and behavioural interventions. The combination of strategies based on a strong biological rational with monitoring their effects using highly informative functional brain imaging methods heralds a new era of scientifically-founded neurorehabilitation.

JOURNAL ARTICLE

Luthi A, Wikstrom MA, Palmer MJ, Matthews P, Benke TA, Isaac JTR, Collingridge GLet al., 2004, Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity, BMC NEUROSCIENCE, Vol: 5, ISSN: 1471-2202

JOURNAL ARTICLE

Ramnani N, Behrens TEJ, Penny W, Matthews PMet al., 2004, New approaches for exploring anatomical and functional connectivity in the human brain, BIOLOGICAL PSYCHIATRY, Vol: 56, Pages: 613-619, ISSN: 0006-3223

JOURNAL ARTICLE

Chen JT, Narayanan S, Collins DL, Smith SM, Matthews PM, Arnold DLet al., 2004, Relating neocortical pathology to disability progression in multiple sclerosis using MRI, NEUROIMAGE, Vol: 23, Pages: 1168-1175, ISSN: 1053-8119

JOURNAL ARTICLE

Cardillo ER, Aydelott J, Matthews PM, Devlin JTet al., 2004, Left inferior prefrontal cortex activity reflects inhibitory rather than facilitatory priming, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 16, Pages: 1552-1561, ISSN: 0898-929X

JOURNAL ARTICLE

Abu-Omar Y, Cader MZ, Balacumaraswami L, Matthews PM, Taggart DPet al., 2004, Cerebral injury following on-pump and off-pump cardiac surgery defined by functional magnetic resonance imaging, 77th Scientific Meeting of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 547-547, ISSN: 0009-7322

CONFERENCE PAPER

Devlin JT, Jamison HL, Matthews PM, Gonnerman LMet al., 2004, Morphology and the internal structure of words, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 14984-14988, ISSN: 0027-8424

JOURNAL ARTICLE

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