Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

585 results found

Devlin JT, Jamison HL, Matthews PM, Gonnerman LMet al., 2004, Morphology and the internal structure of words, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 14984-14988, ISSN: 0027-8424

JOURNAL ARTICLE

Bannerman DM, Matthews P, Deacon RMJ, Rawlins JNPet al., 2004, Medial septal lesions mimic effects of both selective dorsal and ventral hippocampal lesions, BEHAVIORAL NEUROSCIENCE, Vol: 118, Pages: 1033-1041, ISSN: 0735-7044

JOURNAL ARTICLE

Floyer-Lea A, Matthews PM, 2004, Changing brain networks for visuomotor control with increased movement automaticity, JOURNAL OF NEUROPHYSIOLOGY, Vol: 92, Pages: 2405-2412, ISSN: 0022-3077

JOURNAL ARTICLE

Johansen-Berg H, Behrens TEJ, Robson MD, Drobnjak I, Rushworth MFS, Brady JM, Smith SM, Higham DJ, Matthews PMet al., 2004, Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 13335-13340, ISSN: 0027-8424

JOURNAL ARTICLE

Abu-Omar Y, Cifelli A, Matthews PM, Taggart DPet al., 2004, The role of microembolisation in cerebral injury as defined by functional magnetic resonance imaging, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 26, Pages: 586-590, ISSN: 1010-7940

JOURNAL ARTICLE

Vollm BA, de Araujo IE, Cowen PJ, Rolls ET, Kringelbach ML, Smith KA, Jezzard P, Heal RJ, Matthews PMet al., 2004, Methamphetamine activates reward circuitry in drug naive human subjects, NEUROPSYCHOPHARMACOLOGY, Vol: 29, Pages: 1715-1722, ISSN: 0893-133X

JOURNAL ARTICLE

Matthews PM, 2004, Primary progressive multiple sclerosis takes centre stage, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 75, Pages: 1232-1233, ISSN: 0022-3050

JOURNAL ARTICLE

Cader MZ, Cifelli A, Abu-Omar Y, Palace J, Matthews PMet al., 2004, A verbal working memory task reveals new differences in the activation pattern of multiple sclerosis patients compared with healthy controls, 20th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple- Sclerosis/9th Annual Meeting of Rehabilitation in MS, Publisher: ARNOLD, HODDER HEADLINE PLC, Pages: S102-S103, ISSN: 1352-4585

CONFERENCE PAPER

Matthews PM, 2004, An update on neuroimaging of multiple sclerosis, CURRENT OPINION IN NEUROLOGY, Vol: 17, Pages: 453-458, ISSN: 1350-7540

JOURNAL ARTICLE

Arthurs OJ, Johansen-Berg H, Matthews PM, Boniface SJet al., 2004, Attention differentially modulates the coupling of fMRI BOLD and evoked potential signal amplitudes in the human somatosensory cortex, EXPERIMENTAL BRAIN RESEARCH, Vol: 157, Pages: 269-274, ISSN: 0014-4819

JOURNAL ARTICLE

Miller DH, Filippi M, Fazekas F, Frederiksen JL, Matthews PM, Montalban X, Polman CHet al., 2004, Role of magnetic resonance imaging within diagnostic criteria for multiple sclerosis, ANNALS OF NEUROLOGY, Vol: 56, Pages: 273-278, ISSN: 0364-5134

JOURNAL ARTICLE

Saini S, DeStefano N, Smith S, Guidi L, Amato MP, Federico A, Matthews PMet al., 2004, Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 75, Pages: 840-846, ISSN: 0022-3050

JOURNAL ARTICLE

Abu-Omar Y, Balacumaraswami L, Pigott DW, Matthews PM, Taggart DPet al., 2004, Solid and gaseous cerebral microembolization during off-pump, on-pump, and open cardiac surgery procedures, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 127, Pages: 1759-1765, ISSN: 0022-5223

JOURNAL ARTICLE

Abu-Omar Y, Cifelli A, Matthews PM, Taggart DPet al., 2004, Cerebral injury following on pump and off pump cardiac surgery defined by functional MRI, Annual Conference of the British-Cardiac-Society, Publisher: B M J PUBLISHING GROUP, Pages: A27-A27, ISSN: 1355-6037

CONFERENCE PAPER

Enzinger C, Ropele S, Smith S, Strasser-Fuchs S, Poltrum B, Schmidt H, Matthews PM, Fazekas Fet al., 2004, Accelerated evolution of brain atrophy and "Black holes" in MS patients with APOE-epsilon 4, ANNALS OF NEUROLOGY, Vol: 55, Pages: 563-569, ISSN: 0364-5134

JOURNAL ARTICLE

Sahyoun C, Floyer-Lea A, Johansen-Berg H, Matthews PMet al., 2004, Towards an understanding of gait control: brain activation during the anticipation, preparation and execution of foot movements, NEUROIMAGE, Vol: 21, Pages: 568-575, ISSN: 1053-8119

JOURNAL ARTICLE

Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews PM, Cowen PJet al., 2004, Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor, AMERICAN JOURNAL OF PSYCHIATRY, Vol: 161, Pages: 368-370, ISSN: 0002-953X

JOURNAL ARTICLE

Matthews PM, 2004, Commentary on “freud’s theory of mind and functional imaging experiments”, Neuropsychoanalysis, Vol: 6, Pages: 144-149, ISSN: 1529-4145

JOURNAL ARTICLE

Matthews PM, Johansen-Berg H, Reddy H, 2004, Non-invasive mapping of brain functions and brain recovery: Applying lessons from cognitive neuroscience to neurorehabilitation, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, Vol: 22, Pages: 245-260, ISSN: 0922-6028

JOURNAL ARTICLE

Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang YY, De Stefano N, Brady JM, Matthews PMet al., 2004, Advances in functional and structural MR image analysis and implementation as FSL, NEUROIMAGE, Vol: 23, Pages: S208-S219, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, Jezzard P, 2004, Functional magnetic resonance imaging, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 75, Pages: 6-12, ISSN: 0022-3050

JOURNAL ARTICLE

Matthews PM, 2004, Finding landmarks for understanding white matter stroke, STROKE, Vol: 35, Pages: 92-93, ISSN: 0039-2499

JOURNAL ARTICLE

Devlin JT, Raley J, Tunbridge E, Lanary K, Floyer-Lea A, Narain C, Cohen I, Behrens T, Jezzard P, Matthews PM, Moore DRet al., 2003, Functional asymmetry for auditory processing in human primary auditory cortex, JOURNAL OF NEUROSCIENCE, Vol: 23, Pages: 11516-11522, ISSN: 0270-6474

JOURNAL ARTICLE

Narain C, Scott SK, Wise RJS, Rosen S, Leff A, Iversen SD, Matthews PMet al., 2003, Defining a left-lateralized response specific to intelligible speech using fMRI, CEREBRAL CORTEX, Vol: 13, Pages: 1362-1368, ISSN: 1047-3211

JOURNAL ARTICLE

Bridge H, Clare S, Jezzard P, Parker AJ, Matthews PMet al., 2003, A comparison of structurally and functionally defined human primary visual cortex, Journal of Vision, Vol: 3, ISSN: 1534-7362

Early visual areas can be defined using fMRI on the basis of their retinotopic organisation. Recently, very high-resolution images of the human brain in vivo have identified areas of myelination within the grey matter, corresponding to the striate cortex (Barbier et al. 2002; Clare et al. 2002). This myelination has traditionally been understood to correspond to the human primary visual cortex (V1). To test this correspondence, we compared the location of visually identified striate in high resolution images with the location of functionally defined V1. For imaging the myeloarchitecture, a magnetisation prepared 3D FLASH sequence was used as described in Clare et al. (2002). The resulting images had a resolution of 0.3×0.3×1.5 mm. Functional MRI was performed at a lower resolution of 3×3×1.5 mm using single shot EPI at the same 16 slice locations as the structural scan. Retinotopy data were collected using expanding ring and rotating wedge stimuli. The data were transformed onto a segmented (mrGray) and flattened (mrFlatMesh) T1-weighted scan (1×1×1mm). V1 was defined by locating the upper and lower field V1/V2 borders from the rotating wedge phase map. From the high-resolution myeloarchitecture images, striate cortex was conservatively determined as those regions where a stripe was identified within the grey matter. These observer drawn maps of striate cortex were then transformed into flattened space to allow comparison with the functional data. A good level of correspondence was found between the striate cortex determined in the structural MRI and V1 determined by fMRI. While the striate cortex was not identified as a continuous band, it is hoped that more striate will be revealed by using multiple slice orientations in the same subjects. In the future these very high-resolution structural images will offer the opportunity to combine the study of myeloarchitecture with functional architecture in the living human cortex.

JOURNAL ARTICLE

Parry AMM, Scott RB, Palace J, Smith S, Matthews PMet al., 2003, Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine, BRAIN, Vol: 126, Pages: 2750-2760, ISSN: 0006-8950

JOURNAL ARTICLE

Cifelli A, Arnold DL, Matthews PM, 2003, MRI Visualization of Multiple Sclerosis, Myelin Biology and Disorders, Pages: 763-790, ISBN: 9780124395107

This chapter outlines the basic principles of magnetic resonance imaging (MRI) and related techniques. MRI techniques define pathology on the basis of changes in biophysical parameters of tissue. With an understanding of these biophysical parameters, it can be appreciated that they have variably specific relations with pathological features as defined using traditional methods. This visualization of pathological changes in vivo has had a profound impact on the clinical management of patients with multiple sclerosis (MS), and on the understanding of the disease and its treatment. The chapter also reviews several contributions of MRI and related techniques to the understanding of multiple sclerosis (MS) and to pathology. MR and related techniques have been important particularly in emphasizing that much pathological change is subclinical, the diffuse nature of pathology, the prominence of gray matter involvement, and the role of neurodegeneration, even in the early stages of disease evolution. Together, these observations provide a remarkably comprehensive view of key features essential for understanding the way MS progresses. © 2004 Elsevier Inc. All rights reserved.

BOOK CHAPTER

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2003, Erratum: Correlation between motor improvements and altered fMRI activity after rehabilitative therapy (Brain (December 2002) 125: 12 (2731-2742)), Brain, Vol: 126, ISSN: 0006-8950

JOURNAL ARTICLE

Behrens TEJ, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, Clare S, Matthews PM, Brady JM, Smith SMet al., 2003, Characterization and propagation of uncertainty in diffusion-weighted MR imaging, MAGNETIC RESONANCE IN MEDICINE, Vol: 50, Pages: 1077-1088, ISSN: 0740-3194

JOURNAL ARTICLE

Wikstrom MA, Matthews P, Roberts D, Collingridge GL, Bortolotto ZAet al., 2003, Parallel kinase cascades are involved in the induction of LTP at hippocampal CA1 synapses, NEUROPHARMACOLOGY, Vol: 45, Pages: 828-836, ISSN: 0028-3908

JOURNAL ARTICLE

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