Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

585 results found

Abu-Omar Y, Matthews PM, Cifelli A, Taggart DPet al., 2003, Defining cerebral dysfunction related to microembolism during cardiac surgery with functional magnetic resonance imaging, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 512-512, ISSN: 0009-7322

CONFERENCE PAPER

Abu-Omar Y, Balacumaraswami L, Pigott DW, Matthews PM, Taggart DPet al., 2003, Solid and gaseous cerebral microembolisation during off-pump, on-pump and open cardiac surgery, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 549-549, ISSN: 0009-7322

CONFERENCE PAPER

Parry A, Matthews PM, 2003, Roles for imaging in understanding the pathophysiology, clinical evaluation, and management of patients with mitochondrial disease, JOURNAL OF NEUROIMAGING, Vol: 13, Pages: 293-302, ISSN: 1051-2284

JOURNAL ARTICLE

Vollm BA, de Araujo IET, Kringelbach ML, Rolls ET, Cowen P, Matthews PMet al., 2003, Neural correlates of the subjective effects of i.v. amphetamine: an fMRI study in healthy volunteers, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A73-A73, ISSN: 0269-8811

CONFERENCE PAPER

Wegner C, Matthews PM, 2003, A new view of the cortex, new insights into multiple sclerosis, BRAIN, Vol: 126, Pages: 1719-1721, ISSN: 0006-8950

JOURNAL ARTICLE

Palace J, Parry A, Clare S, Jenkinson M, Smith S, Matthews PMet al., 2003, T1 changes detect the progression of pathology in the white matter and cortex of MS patients, Joint Congress of the Association-of-British-Neurologists/Neurological-Association-of-South-Africa, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 1179-1179, ISSN: 0022-3050

CONFERENCE PAPER

Behrens TEJ, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CAM, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PMet al., 2003, Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging, NATURE NEUROSCIENCE, Vol: 6, Pages: 750-757, ISSN: 1097-6256

JOURNAL ARTICLE

Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PMet al., 2003, MRI brain T1 relaxation time changes in MS patients increase over time in both the white matter and the cortex, JOURNAL OF NEUROIMAGING, Vol: 13, Pages: 234-239, ISSN: 1051-2284

JOURNAL ARTICLE

Wylezinska M, Cifelli A, Jezzard P, Palace J, Alecci M, Matthews PMet al., 2003, Thalamic neurodegeneration in relapsing-remitting multiple sclerosis, NEUROLOGY, Vol: 60, Pages: 1949-1954, ISSN: 0028-3878

JOURNAL ARTICLE

Austin VC, Blamire AM, Grieve SM, O'Neill MJ, Styles P, Matthews PM, Sibson NRet al., 2003, Differences in the BOLD fMRI response to direct and indirect cortical stimulation in the rat, MAGNETIC RESONANCE IN MEDICINE, Vol: 49, Pages: 838-847, ISSN: 0740-3194

JOURNAL ARTICLE

Vollm BA, Araujo I, Kringelbach M, Rolls ET, Cowen PJ, Matthews PMet al., 2003, Neural correlates of the subjective effects of IV amphetamine: An fMRI study in healthy volunteers, 58th Annual Convention and Scientific Program of the Society-of-Biological-Psychiatry, Publisher: ELSEVIER SCIENCE INC, Pages: 216S-216S, ISSN: 0006-3223

CONFERENCE PAPER

De Stefano N, Matthews PM, Filippi M, Agosta F, De Luca M, Bartolozzi ML, Guidi L, Ghezzi A, Montanari E, Cifelli A, Federico A, Smith SMet al., 2003, Evidence of early cortical atrophy in MS relevance to white matter changes and disability, 54th Annual Meeting of the American-Academy-of-Neurology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1157-1162, ISSN: 0028-3878

CONFERENCE PAPER

Matthews PM, Adcock J, Chen Y, Fu S, Devlin JT, Rushworth MFS, Smith S, Beckmann C, Iversen Set al., 2003, Towards understanding language organisation in the brain using fMRI, HUMAN BRAIN MAPPING, Vol: 18, Pages: 239-247, ISSN: 1065-9471

JOURNAL ARTICLE

Parry A, Corkill R, Blamire AM, Palace J, Narayanan S, Arnold D, Styles P, Matthews PMet al., 2003, Beta-interferon treatment does not always slow the progression of axonal injury in multiple sclerosis, JOURNAL OF NEUROLOGY, Vol: 250, Pages: 171-178, ISSN: 0340-5354

JOURNAL ARTICLE

Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Matthews PMet al., 2003, Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy, NEUROIMAGE, Vol: 18, Pages: 423-438, ISSN: 1053-8119

JOURNAL ARTICLE

Devlin JT, Matthews PM, Rushworth MFS, 2003, Semantic processing in the left inferior prefrontal cortex: A combined functional magnetic resonance imaging and transcranial magnetic stimulation study, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 15, Pages: 71-84, ISSN: 0898-929X

JOURNAL ARTICLE

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2002, Correlation between motor improvements and altered fMRI activity after rehabilitative therapy, BRAIN, Vol: 125, Pages: 2731-2742, ISSN: 0006-8950

JOURNAL ARTICLE

Robinson GV, Miall RC, Matthews PM, Jones EM, Winter J, Stein J, Stradling JR, Davies RJOet al., 2002, Brain fMRI activation and evoked potentials during visual stimulation and visuo-motor tracking in normal subjects before and after sleep deprivation, Winter Meeting of the British-Thoracic-Society, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0040-6376

CONFERENCE PAPER

Reddy H, Narayanan S, Woolrich M, Mitsumori T, Lapierre Y, Arnold DL, Matthews PMet al., 2002, Functional brain reorganization for hand movement in patients with multiple sclerosis: defining distinct effects of injury and disability, BRAIN, Vol: 125, Pages: 2646-2657, ISSN: 0006-8950

JOURNAL ARTICLE

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2002, Correlation between motor improvements and altered fMRI activity after rehabilitative therapy, Brain, Vol: 125, Pages: 2731-2742, ISSN: 0006-8950

Motor rehabilitation therapy is commonly employed after strokes, but outcomes are variable and there is little specific information about the changes in brain activity that are associated with improved function. We performed serial functional MRI (fMRI) on a group of seven patients receiving a form of rehabilitation therapy after stroke in order to characterize functional changes in the brain that correlate with behavioural improvements. Patients were scanned while performing a hand flexion-extension movement twice before and twice after a two-week home-based therapy programme combining restraint of the unaffected limb with progressive exercises for the affected limb. As expected, the extent of improvement in hand function after therapy varied between patients. Therapy-related improvements in hand function correlated with increases in fMRI activity in the premotor cortex and secondary somatosensory cortex contralateral to the affected hand, and in superior posterior regions of the cerebellar hemispheres bilaterally (Crus I and lobule VI). fMRI offers a promising, objective approach for specifically identifying changes in brain activity potentially responsible for rehabilitation-mediated recovery of function after stroke. Our results suggest that activity changes in sensorimotor regions are associated with successful motor rehabilitation.

JOURNAL ARTICLE

Reddy H, Narayanan S, Woolrich M, Mitsumori T, Lapierre Y, Arnold DL, Matthews PMet al., 2002, Functional brain reorganization for hand movement in patients with multiple sclerosis: Defining distinct effects of injury and disability, Brain, Vol: 125, Pages: 2646-2657, ISSN: 0006-8950

Previous work has demonstrated potentially adaptive cortical plasticity that increases with brain injury in patients with multiple sclerosis. However, animal studies showing use-dependent changes in motor cortex organization suggest that functional changes also may occur in response to disability. We therefore wished to test whether brain injury and disability lead to distinguishable patterns of activation with hand movement in patients with multiple sclerosis. By employing a passive as well as an active movement task, we also wished to test whether these changes were independent of voluntary recruitment and thus mor likely to reflect true functional reorganization. Fourteen patients [Extended Disability Status Score (EDSS) 0-7.5] with relapsing- remitting multiple sclerosis were selected on the basis of pathology load and hand functional impairment for three study groups: group 1, low diffuse central brain injury (DCBI) as assessed from relative N-acetylaspartate concentration (a marker of axonal integrity) and normal hand function (n = 6); group 2, greater DCBI and normal hand function (n = 4); and group 3, greater DCBI and impaired hand function (n = 4). Functional MRI (fMRI) was used to map brain activation with a four-finger and both one-finger passive and active flexion-extension movement tasks for the three groups. Considering all the patients, we found increased activity in ipsilateral premotor and ipsilateral motor cortex (IMC) and in the ipsilateral inferior parietal lobule with increasing global disability (as assessed from the EDSS score). These changes appear to define true functional reorganization, as fMRI activations in IMC (r = 0.87, P < 0.001) and in the contralateral motor cortex (r = 0.67, P < 0.007) were highly correlated between active and passive single finger movements. We attempted to disambiguate any distinct effects of disability and brain injury by direct contrasts between patients differing predominantly in one or the other. To mak

JOURNAL ARTICLE

Fu SM, Chen YP, Smith S, Iversen S, Matthews PMet al., 2002, Effects of word form on brain processing of written Chinese, NEUROIMAGE, Vol: 17, Pages: 1538-1548, ISSN: 1053-8119

JOURNAL ARTICLE

Smith KA, Ploghaus A, Cowen PJ, McCleery JM, Goodwin GM, Smith S, Tracey I, Matthews PMet al., 2002, Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression - Functional magnetic resonance imaging study, BRITISH JOURNAL OF PSYCHIATRY, Vol: 181, Pages: 411-415, ISSN: 0007-1250

JOURNAL ARTICLE

Cifelli A, Arridge M, Jezzard P, Esiri MM, Palace J, Matthews PMet al., 2002, Thalamic neurodegeneration in multiple sclerosis, ANNALS OF NEUROLOGY, Vol: 52, Pages: 650-653, ISSN: 0364-5134

JOURNAL ARTICLE

Johansen-Berg H, Rushworth MFS, Bogdanovic MD, Kischka U, Wimalaratna S, Matthews PMet al., 2002, The role of ipsilateral premotor cortex in hand movement after stroke, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 14518-14523, ISSN: 0027-8424

JOURNAL ARTICLE

Chen YP, Fu SM, Iversen SD, Smith SM, Matthews PMet al., 2002, Testing for dual brain processing routes in reading: A direct contrast of chinese character and pinyin reading using fMRI, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 14, Pages: 1088-1098, ISSN: 0898-929X

JOURNAL ARTICLE

Andrews TJ, Schluppeck D, Homfray D, Matthews P, Blakemore Cet al., 2002, Activity in the fusiform gyrus predicts conscious perception of Rubin's vase-face illusion, NEUROIMAGE, Vol: 17, Pages: 890-901, ISSN: 1053-8119

JOURNAL ARTICLE

Smith SM, Zhang YY, Jenkinson M, Chen J, Matthews PM, Federico A, De Stefano Net al., 2002, Accurate, robust, and automated longitudinal and cross-sectional brain change analysis, NEUROIMAGE, Vol: 17, Pages: 479-489, ISSN: 1053-8119

JOURNAL ARTICLE

Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PMet al., 2002, White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis, JOURNAL OF NEUROLOGY, Vol: 249, Pages: 1279-1286, ISSN: 0340-5354

JOURNAL ARTICLE

Parry A, Corkill R, Blamire A, Palace J, Narayanan S, Arnold D, Styles P, Matthews PMet al., 2002, beta-interferon treatment does not immediately slow the progression of axonal injury in multiple sclerosis, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 73, Pages: 214-214, ISSN: 0022-3050

JOURNAL ARTICLE

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