Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

594 results found

Cifelli A, Arnold DL, Matthews PM, 2003, MRI Visualization of Multiple Sclerosis, Myelin Biology and Disorders, Pages: 763-790, ISBN: 9780124395107

This chapter outlines the basic principles of magnetic resonance imaging (MRI) and related techniques. MRI techniques define pathology on the basis of changes in biophysical parameters of tissue. With an understanding of these biophysical parameters, it can be appreciated that they have variably specific relations with pathological features as defined using traditional methods. This visualization of pathological changes in vivo has had a profound impact on the clinical management of patients with multiple sclerosis (MS), and on the understanding of the disease and its treatment. The chapter also reviews several contributions of MRI and related techniques to the understanding of multiple sclerosis (MS) and to pathology. MR and related techniques have been important particularly in emphasizing that much pathological change is subclinical, the diffuse nature of pathology, the prominence of gray matter involvement, and the role of neurodegeneration, even in the early stages of disease evolution. Together, these observations provide a remarkably comprehensive view of key features essential for understanding the way MS progresses. © 2004 Elsevier Inc. All rights reserved.

Book chapter

Parry AMM, Scott RB, Palace J, Smith S, Matthews PMet al., 2003, Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine, BRAIN, Vol: 126, Pages: 2750-2760, ISSN: 0006-8950

Journal article

Bridge H, Clare S, Jezzard P, Parker AJ, Matthews PMet al., 2003, A comparison of structurally and functionally defined human primary visual cortex, Journal of Vision, Vol: 3, ISSN: 1534-7362

Early visual areas can be defined using fMRI on the basis of their retinotopic organisation. Recently, very high-resolution images of the human brain in vivo have identified areas of myelination within the grey matter, corresponding to the striate cortex (Barbier et al. 2002; Clare et al. 2002). This myelination has traditionally been understood to correspond to the human primary visual cortex (V1). To test this correspondence, we compared the location of visually identified striate in high resolution images with the location of functionally defined V1. For imaging the myeloarchitecture, a magnetisation prepared 3D FLASH sequence was used as described in Clare et al. (2002). The resulting images had a resolution of 0.3×0.3×1.5 mm. Functional MRI was performed at a lower resolution of 3×3×1.5 mm using single shot EPI at the same 16 slice locations as the structural scan. Retinotopy data were collected using expanding ring and rotating wedge stimuli. The data were transformed onto a segmented (mrGray) and flattened (mrFlatMesh) T1-weighted scan (1×1×1mm). V1 was defined by locating the upper and lower field V1/V2 borders from the rotating wedge phase map. From the high-resolution myeloarchitecture images, striate cortex was conservatively determined as those regions where a stripe was identified within the grey matter. These observer drawn maps of striate cortex were then transformed into flattened space to allow comparison with the functional data. A good level of correspondence was found between the striate cortex determined in the structural MRI and V1 determined by fMRI. While the striate cortex was not identified as a continuous band, it is hoped that more striate will be revealed by using multiple slice orientations in the same subjects. In the future these very high-resolution structural images will offer the opportunity to combine the study of myeloarchitecture with functional architecture in the living human cortex.

Journal article

Behrens TEJ, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, Clare S, Matthews PM, Brady JM, Smith SMet al., 2003, Characterization and propagation of uncertainty in diffusion-weighted MR imaging, MAGNETIC RESONANCE IN MEDICINE, Vol: 50, Pages: 1077-1088, ISSN: 0740-3194

Journal article

Wikstrom MA, Matthews P, Roberts D, Collingridge GL, Bortolotto ZAet al., 2003, Parallel kinase cascades are involved in the induction of LTP at hippocampal CA1 synapses, NEUROPHARMACOLOGY, Vol: 45, Pages: 828-836, ISSN: 0028-3908

Journal article

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2003, Erratum: Correlation between motor improvements and altered fMRI activity after rehabilitative therapy (Brain (December 2002) 125: 12 (2731-2742)), Brain, Vol: 126, ISSN: 0006-8950

Journal article

Abu-Omar Y, Balacumaraswami L, Pigott DW, Matthews PM, Taggart DPet al., 2003, Solid and gaseous cerebral microembolisation during off-pump, on-pump and open cardiac surgery, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 549-549, ISSN: 0009-7322

Conference paper

Abu-Omar Y, Matthews PM, Cifelli A, Taggart DPet al., 2003, Defining cerebral dysfunction related to microembolism during cardiac surgery with functional magnetic resonance imaging, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 512-512, ISSN: 0009-7322

Conference paper

Parry A, Matthews PM, 2003, Roles for Imaging in Understanding the Pathophysiology, Clinical Evaluation, and Management of Patients with Mitochondrial Disease, Journal of Neuroimaging, Vol: 13, Pages: 293-302, ISSN: 1051-2284

Journal article

Parry A, Matthews PM, 2003, Roles for imaging in understanding the pathophysiology, clinical evaluation, and management of patients with mitochondrial disease, JOURNAL OF NEUROIMAGING, Vol: 13, Pages: 293-302, ISSN: 1051-2284

Journal article

Vollm BA, de Araujo IET, Kringelbach ML, Rolls ET, Cowen P, Matthews PMet al., 2003, Neural correlates of the subjective effects of i.v. amphetamine: an fMRI study in healthy volunteers, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A73-A73, ISSN: 0269-8811

Conference paper

Wegner C, Matthews PM, 2003, A new view of the cortex, new insights into multiple sclerosis, BRAIN, Vol: 126, Pages: 1719-1721, ISSN: 0006-8950

Journal article

Palace J, Parry A, Clare S, Jenkinson M, Smith S, Matthews PMet al., 2003, T1 changes detect the progression of pathology in the white matter and cortex of MS patients, Joint Congress of the Association-of-British-Neurologists/Neurological-Association-of-South-Africa, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 1179-1179, ISSN: 0022-3050

Conference paper

Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PMet al., 2003, MRI brain T1 relaxation time changes in MS patients increase over time in both the white matter and the cortex, JOURNAL OF NEUROIMAGING, Vol: 13, Pages: 234-239, ISSN: 1051-2284

Journal article

Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PMet al., 2003, MRI Brain T1 Relaxation Time Changes in MS Patients Increase Over Time in Both the White Matter and the Cortex, Journal of Neuroimaging, Vol: 13, Pages: 234-239, ISSN: 1051-2284

Journal article

Behrens TEJ, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CAM, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PMet al., 2003, Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging, NATURE NEUROSCIENCE, Vol: 6, Pages: 750-757, ISSN: 1097-6256

Journal article

Wylezinska M, Cifelli A, Jezzard P, Palace J, Alecci M, Matthews PMet al., 2003, Thalamic neurodegeneration in relapsing-remitting multiple sclerosis, NEUROLOGY, Vol: 60, Pages: 1949-1954, ISSN: 0028-3878

Journal article

Austin VC, Blamire AM, Grieve SM, O'Neill MJ, Styles P, Matthews PM, Sibson NRet al., 2003, Differences in the BOLD fMRI response to direct and indirect cortical stimulation in the rat, MAGNETIC RESONANCE IN MEDICINE, Vol: 49, Pages: 838-847, ISSN: 0740-3194

Journal article

Vollm BA, Araujo I, Kringelbach M, Rolls ET, Cowen PJ, Matthews PMet al., 2003, Neural correlates of the subjective effects of IV amphetamine: An fMRI study in healthy volunteers, 58th Annual Convention and Scientific Program of the Society-of-Biological-Psychiatry, Publisher: ELSEVIER SCIENCE INC, Pages: 216S-216S, ISSN: 0006-3223

Conference paper

De Stefano N, Matthews PM, Filippi M, Agosta F, De Luca M, Bartolozzi ML, Guidi L, Ghezzi A, Montanari E, Cifelli A, Federico A, Smith SMet al., 2003, Evidence of early cortical atrophy in MS relevance to white matter changes and disability, 54th Annual Meeting of the American-Academy-of-Neurology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1157-1162, ISSN: 0028-3878

Conference paper

Matthews PM, Adcock J, Chen Y, Fu S, Devlin JT, Rushworth MFS, Smith S, Beckmann C, Iversen Set al., 2003, Towards understanding language organisation in the brain using fMRI, HUMAN BRAIN MAPPING, Vol: 18, Pages: 239-247, ISSN: 1065-9471

Journal article

Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Matthews PMet al., 2003, Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy, NEUROIMAGE, Vol: 18, Pages: 423-438, ISSN: 1053-8119

Journal article

Parry A, Corkill R, Blamire AM, Palace J, Narayanan S, Arnold D, Styles P, Matthews PMet al., 2003, Beta-interferon treatment does not always slow the progression of axonal injury in multiple sclerosis, JOURNAL OF NEUROLOGY, Vol: 250, Pages: 171-178, ISSN: 0340-5354

Journal article

Devlin JT, Matthews PM, Rushworth MFS, 2003, Semantic processing in the left inferior prefrontal cortex: A combined functional magnetic resonance imaging and transcranial magnetic stimulation study, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 15, Pages: 71-84, ISSN: 0898-929X

Journal article

Reddy H, Narayanan S, Woolrich M, Mitsumori T, Lapierre Y, Arnold DL, Matthews PMet al., 2002, Functional brain reorganization for hand movement in patients with multiple sclerosis: defining distinct effects of injury and disability, BRAIN, Vol: 125, Pages: 2646-2657, ISSN: 0006-8950

Journal article

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2002, Correlation between motor improvements and altered fMRI activity after rehabilitative therapy, BRAIN, Vol: 125, Pages: 2731-2742, ISSN: 0006-8950

Journal article

Reddy H, Narayanan S, Woolrich M, Mitsumori T, Lapierre Y, Arnold DL, Matthews PMet al., 2002, Functional brain reorganization for hand movement in patients with multiple sclerosis: Defining distinct effects of injury and disability, Brain, Vol: 125, Pages: 2646-2657, ISSN: 0006-8950

Previous work has demonstrated potentially adaptive cortical plasticity that increases with brain injury in patients with multiple sclerosis. However, animal studies showing use-dependent changes in motor cortex organization suggest that functional changes also may occur in response to disability. We therefore wished to test whether brain injury and disability lead to distinguishable patterns of activation with hand movement in patients with multiple sclerosis. By employing a passive as well as an active movement task, we also wished to test whether these changes were independent of voluntary recruitment and thus mor likely to reflect true functional reorganization. Fourteen patients [Extended Disability Status Score (EDSS) 0-7.5] with relapsing- remitting multiple sclerosis were selected on the basis of pathology load and hand functional impairment for three study groups: group 1, low diffuse central brain injury (DCBI) as assessed from relative N-acetylaspartate concentration (a marker of axonal integrity) and normal hand function (n = 6); group 2, greater DCBI and normal hand function (n = 4); and group 3, greater DCBI and impaired hand function (n = 4). Functional MRI (fMRI) was used to map brain activation with a four-finger and both one-finger passive and active flexion-extension movement tasks for the three groups. Considering all the patients, we found increased activity in ipsilateral premotor and ipsilateral motor cortex (IMC) and in the ipsilateral inferior parietal lobule with increasing global disability (as assessed from the EDSS score). These changes appear to define true functional reorganization, as fMRI activations in IMC (r = 0.87, P < 0.001) and in the contralateral motor cortex (r = 0.67, P < 0.007) were highly correlated between active and passive single finger movements. We attempted to disambiguate any distinct effects of disability and brain injury by direct contrasts between patients differing predominantly in one or the other. To mak

Journal article

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2002, Correlation between motor improvements and altered fMRI activity after rehabilitative therapy, Brain, Vol: 125, Pages: 2731-2742, ISSN: 0006-8950

Motor rehabilitation therapy is commonly employed after strokes, but outcomes are variable and there is little specific information about the changes in brain activity that are associated with improved function. We performed serial functional MRI (fMRI) on a group of seven patients receiving a form of rehabilitation therapy after stroke in order to characterize functional changes in the brain that correlate with behavioural improvements. Patients were scanned while performing a hand flexion-extension movement twice before and twice after a two-week home-based therapy programme combining restraint of the unaffected limb with progressive exercises for the affected limb. As expected, the extent of improvement in hand function after therapy varied between patients. Therapy-related improvements in hand function correlated with increases in fMRI activity in the premotor cortex and secondary somatosensory cortex contralateral to the affected hand, and in superior posterior regions of the cerebellar hemispheres bilaterally (Crus I and lobule VI). fMRI offers a promising, objective approach for specifically identifying changes in brain activity potentially responsible for rehabilitation-mediated recovery of function after stroke. Our results suggest that activity changes in sensorimotor regions are associated with successful motor rehabilitation.

Journal article

Robinson GV, Miall RC, Matthews PM, Jones EM, Winter J, Stein J, Stradling JR, Davies RJOet al., 2002, Brain fMRI activation and evoked potentials during visual stimulation and visuo-motor tracking in normal subjects before and after sleep deprivation, Winter Meeting of the British-Thoracic-Society, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0040-6376

Conference paper

Fu SM, Chen YP, Smith S, Iversen S, Matthews PMet al., 2002, Effects of word form on brain processing of written Chinese, NEUROIMAGE, Vol: 17, Pages: 1538-1548, ISSN: 1053-8119

Journal article

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