594 results found
TAYLOR DJ, MATTHEWS PM, RADDA GK, 1986, MYOGLOBIN-DEPENDENT OXIDATIVE-METABOLISM IN THE HYPOXIC RAT-HEART, RESPIRATION PHYSIOLOGY, Vol: 63, Pages: 275-283, ISSN: 0034-5687
TAYLOR DJ, STYLES P, MATTHEWS PM, et al., 1986, ENERGETICS OF HUMAN-MUSCLE - EXERCISE-INDUCED ATP DEPLETION, MAGNETIC RESONANCE IN MEDICINE, Vol: 3, Pages: 44-54, ISSN: 0740-3194
Malloy CR, Matthews PM, Smith MB, et al., 1986, Influence of propranolol on acidosis and high energy phosphates in ischaemic myocardium of the rabbit, Cardiovascular Research, Vol: 20, Pages: 710-720, ISSN: 0008-6363
MATTHEWS PM, TAYLOR DJ, RADDA GK, 1986, BIOCHEMICAL-MECHANISMS OF ACUTE CONTRACTILE FAILURE IN THE HYPOXIC RAT-HEART, CARDIOVASCULAR RESEARCH, Vol: 20, Pages: 13-19, ISSN: 0008-6363
MATTHEWS PM, FOXALL D, SHEN LF, et al., 1986, NUCLEAR-MAGNETIC-RESONANCE STUDIES OF CARBOHYDRATE-METABOLISM AND SUBSTRATE CYCLING IN FASCIOLA-HEPATICA, MOLECULAR PHARMACOLOGY, Vol: 29, Pages: 65-73, ISSN: 0026-895X
MATTHEWS PM, SHEN LF, FOXALL D, et al., 1985, P-31-NMR STUDIES OF METABOLITE COMPARTMENTATION IN FASCIOLA-HEPATICA, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 845, Pages: 178-188, ISSN: 0006-3002
Malloy CR, Matthews PM, Smith MB, et al., 1985, In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia., Adv Myocardiol, Vol: 6, Pages: 461-464, ISSN: 0270-4056
We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.
Keogh JM, Matthews PM, Seymour AM, et al., 1985, A phosphorus-31 nuclear magnetic resonance study of effects of altered thyroid state on cardiac bioenergetics., Adv Myocardiol, Vol: 6, Pages: 299-309, ISSN: 0270-4056
We have used 31P nuclear magnetic resonance (NMR) techniques to characterize bioenergetic changes in the Langendorff-perfused rat heart accompanying alterations in thyroid state. Cytosolic phosphocreatine and inorganic phosphate concentrations changed significantly in both the hypo- and hyperthyroid groups compared to controls; the calculated phosphorylation potential [( ATP]/[ADP][Pi]) increased by 60% in hypothyroidism and decreased by 60% in hyperthyroidism relative to the euthyroid value of 47 X 10(3) M-1. Creatine phosphokinase (CPK) and mitochondrial ATP synthase rates were measured in the intact tissue using a saturation-transfer NMR method. There were no significant differences in the measured fluxes through the CPK reaction among the three groups (4.24 +/- 1.00 mM X sec-1 for the euthyroid group). Although O2 consumption increased by 46% in hearts from hyperthyroid animals, no change in the measured mitochondrial ATP synthase flux was observed compared to the euthyroid flux of 1.05 +/- 0.11 mM X sec-1. These results suggest that the apparent in situ P/O ratio of mitochondria in hearts from hyperthyroid animals is reduced relative to that in euthyroid controls.
Shen L, Matthews PM, Foxall DL, et al., 1984, **3**1P NMR QUANTITATIVE STUDY OF THE LIVER FLUKE FASCIOLA HEPATICA., Pages: 473-474
Quantitative **3**1P spectra of intact Fasciola hepatica and their perchloric extracts were obtained under normal and sugar-depleted conditions. Resonances were identified and quantified.
ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, METABOLIC RECOVERY AFTER EXERCISE AND THE ASSESSMENT OF MITOCHONDRIAL-FUNCTION INVIVO IN HUMAN SKELETAL-MUSCLE BY MEANS OF P-31 NMR, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 307-315, ISSN: 0740-3194
RADDA GK, TAYLOR DJ, STYLES P, et al., 1984, EXERCISE-INDUCED ATP DEPLETION IN NORMAL HUMAN-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 229-229, ISSN: 0740-3194
MALLOY CR, MATTHEWS PM, SMITH MB, et al., 1984, INFLUENCE OF PROPRANOLOL ON THE RESPONSE TO REGIONAL CARDIAC ISCHEMIA MONITORED INVIVO BY P-31 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY, CLINICAL RESEARCH, Vol: 32, Pages: A187-A187, ISSN: 0009-9279
ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, APPLICATION OF P-31 NMR TO ASSESSMENT OF MITOCHONDRIAL-FUNCTION IN HUMAN SKELETAL-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 90-90, ISSN: 0740-3194
MATTHEWS PM, BLAND JL, RADDA GK, 1983, THE TEMPERATURE-DEPENDENCE OF CREATINE-KINASE FLUXES IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 763, Pages: 140-146, ISSN: 0006-3002
Matthews PM, Bland JJ, Radda GK, 1983, The temperature-dependence of steady-state creatine kinase fluxes in rat cardiac muscle, Biochemical Society Transactions, Vol: 11, Pages: 174-175, ISSN: 0300-5127
THULBORN KR, WATERTON JC, MATTHEWS PM, et al., 1982, OXYGENATION DEPENDENCE OF THE TRANSVERSE RELAXATION-TIME OF WATER PROTONS IN WHOLE-BLOOD AT HIGH-FIELD, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 714, Pages: 265-270, ISSN: 0006-3002
MATTHEWS PM, WILLIAMS SR, SEYMOUR AM, et al., 1982, A P-31-NMR STUDY OF SOME METABOLIC AND FUNCTIONAL-EFFECTS OF THE INOTROPIC AGENTS EPINEPHRINE AND OUABAIN, AND THE IONOPHORE RO2-2985 (X537A) IN THE ISOLATED, PERFUSED RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 720, Pages: 163-171, ISSN: 0006-3002
MATTHEWS PM, BLAND JL, GADIAN DG, et al., 1982, A P-31-NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 721, Pages: 312-320, ISSN: 0006-3002
Jennings RC, Gerola PD, Garlaschi FM, et al., 1981, Studies of metabolism in the isolated, perfused rat heart using <sup>13</sup>C NMR, FEBS Letters, Vol: 123, Pages: 315-318, ISSN: 0014-5793
Matthews PM, Radda GK, Taylor DJ, 1981, A <sup>31</sup>P n.m.r. study of metabolism in the hypoxic perfused rat heart, Biochemical Society Transactions, Vol: 9, Pages: 236-237, ISSN: 0300-5127
BAILEY IA, GADIAN DG, MATTHEWS PM, et al., 1981, STUDIES OF METABOLISM IN THE ISOLATED, PERFUSED RAT-HEART USING C-13 NMR, FEBS LETTERS, Vol: 123, Pages: 315-318, ISSN: 0014-5793
MATTHEWS PM, BLAND JL, GADIAN DG, et al., 1981, A 31-P NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE PERFUSED RAT-HEART, FEDERATION PROCEEDINGS, Vol: 40, Pages: 1625-1625, ISSN: 0014-9446
MATTHEWS PM, BLAND JL, GADIAN DG, et al., 1981, THE STEADY-STATE RATE OF ATP SYNTHESIS IN THE PERFUSED RAT-HEART MEASURED BY P-31 NMR SATURATION TRANSFER, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 103, Pages: 1052-1059, ISSN: 0006-291X
WILLIAMS SR, MATTHEWS PM, SCHWARTZ A, et al., 1980, THE RELATIONSHIP BETWEEN PRESSURE DEVELOPMENT INDUCED BY INOTROPIC AGENTS, AND HIGH-ENERGY PHOSPHATE-COMPOUNDS IN THE LANGENDORF (L) PERFUSED RAT-HEART - A P-31-NMR STUDY, FEDERATION PROCEEDINGS, Vol: 39, Pages: 2113-2113, ISSN: 0014-9446
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