Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

599 results found

MATTHEWS PM, ANDERMANN F, ARNOLD DL, 1990, A PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY OF FOCAL EPILEPSY IN HUMANS, NEUROLOGY, Vol: 40, Pages: 985-989, ISSN: 0028-3878

Journal article

ARNOLD DL, MATTHEWS PM, FRANCIS G, ANTEL Jet al., 1990, PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN INVIVO IN THE EVALUATION OF MULTIPLE-SCLEROSIS - ASSESSMENT OF THE LOAD OF DISEASE, MAGNETIC RESONANCE IN MEDICINE, Vol: 14, Pages: 154-159, ISSN: 0740-3194

Journal article

MATTHEWS PM, EVANS AC, ANDERMANN F, HAKIM AMet al., 1989, REGIONAL CEREBRAL GLUCOSE-METABOLISM DIFFERS IN ADULT AND RIGID JUVENILE FORMS OF HUNTINGTON DISEASE, PEDIATRIC NEUROLOGY, Vol: 5, Pages: 353-356, ISSN: 0887-8994

Journal article

MATTHEWS PM, SHOUBRIDGE E, ARNOLD DL, 1989, BRAIN PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE BACTERIAL-MENINGITIS, ARCHIVES OF NEUROLOGY, Vol: 46, Pages: 994-996, ISSN: 0003-9942

Journal article

MALLOY CR, MATTHEWS PM, SMITH MB, RADDA GKet al., 1986, INFLUENCE OF PROPRANOLOL ON ACIDOSIS AND HIGH-ENERGY PHOSPHATES IN ISCHEMIC MYOCARDIUM OF THE RABBIT, CARDIOVASCULAR RESEARCH, Vol: 20, Pages: 710-720, ISSN: 0008-6363

Journal article

TAYLOR DJ, MATTHEWS PM, RADDA GK, 1986, MYOGLOBIN-DEPENDENT OXIDATIVE-METABOLISM IN THE HYPOXIC RAT-HEART, RESPIRATION PHYSIOLOGY, Vol: 63, Pages: 275-283, ISSN: 0034-5687

Journal article

TAYLOR DJ, STYLES P, MATTHEWS PM, ARNOLD DA, GADIAN DG, BORE P, RADDA GKet al., 1986, ENERGETICS OF HUMAN-MUSCLE - EXERCISE-INDUCED ATP DEPLETION, MAGNETIC RESONANCE IN MEDICINE, Vol: 3, Pages: 44-54, ISSN: 0740-3194

Journal article

Malloy CR, Matthews PM, Smith MB, Radda GKet al., 1986, Influence of propranolol on acidosis and high energy phosphates in ischaemic myocardium of the rabbit, Cardiovascular Research, Vol: 20, Pages: 710-720, ISSN: 0008-6363

Journal article

MATTHEWS PM, TAYLOR DJ, RADDA GK, 1986, BIOCHEMICAL-MECHANISMS OF ACUTE CONTRACTILE FAILURE IN THE HYPOXIC RAT-HEART, CARDIOVASCULAR RESEARCH, Vol: 20, Pages: 13-19, ISSN: 0008-6363

Journal article

MATTHEWS PM, FOXALL D, SHEN LF, MANSOUR TEet al., 1986, NUCLEAR-MAGNETIC-RESONANCE STUDIES OF CARBOHYDRATE-METABOLISM AND SUBSTRATE CYCLING IN FASCIOLA-HEPATICA, MOLECULAR PHARMACOLOGY, Vol: 29, Pages: 65-73, ISSN: 0026-895X

Journal article

MATTHEWS PM, SHEN LF, FOXALL D, MANSOUR TEet al., 1985, P-31-NMR STUDIES OF METABOLITE COMPARTMENTATION IN FASCIOLA-HEPATICA, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 845, Pages: 178-188, ISSN: 0006-3002

Journal article

Malloy CR, Matthews PM, Smith MB, Radda GKet al., 1985, In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia., Adv Myocardiol, Vol: 6, Pages: 461-464, ISSN: 0270-4056

We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

Journal article

Keogh JM, Matthews PM, Seymour AM, Radda GKet al., 1985, A phosphorus-31 nuclear magnetic resonance study of effects of altered thyroid state on cardiac bioenergetics., Adv Myocardiol, Vol: 6, Pages: 299-309, ISSN: 0270-4056

We have used 31P nuclear magnetic resonance (NMR) techniques to characterize bioenergetic changes in the Langendorff-perfused rat heart accompanying alterations in thyroid state. Cytosolic phosphocreatine and inorganic phosphate concentrations changed significantly in both the hypo- and hyperthyroid groups compared to controls; the calculated phosphorylation potential [( ATP]/[ADP][Pi]) increased by 60% in hypothyroidism and decreased by 60% in hyperthyroidism relative to the euthyroid value of 47 X 10(3) M-1. Creatine phosphokinase (CPK) and mitochondrial ATP synthase rates were measured in the intact tissue using a saturation-transfer NMR method. There were no significant differences in the measured fluxes through the CPK reaction among the three groups (4.24 +/- 1.00 mM X sec-1 for the euthyroid group). Although O2 consumption increased by 46% in hearts from hyperthyroid animals, no change in the measured mitochondrial ATP synthase flux was observed compared to the euthyroid flux of 1.05 +/- 0.11 mM X sec-1. These results suggest that the apparent in situ P/O ratio of mitochondria in hearts from hyperthyroid animals is reduced relative to that in euthyroid controls.

Journal article

Shen L, Matthews PM, Foxall DL, Mansour TEet al., 1984, **3**1P NMR QUANTITATIVE STUDY OF THE LIVER FLUKE FASCIOLA HEPATICA., Pages: 473-474

Quantitative **3**1P spectra of intact Fasciola hepatica and their perchloric extracts were obtained under normal and sugar-depleted conditions. Resonances were identified and quantified.

Conference paper

ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, METABOLIC RECOVERY AFTER EXERCISE AND THE ASSESSMENT OF MITOCHONDRIAL-FUNCTION INVIVO IN HUMAN SKELETAL-MUSCLE BY MEANS OF P-31 NMR, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 307-315, ISSN: 0740-3194

Journal article

RADDA GK, TAYLOR DJ, STYLES P, BORE PJ, MATTHEWS PM, GADIAN DGet al., 1984, EXERCISE-INDUCED ATP DEPLETION IN NORMAL HUMAN-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 229-229, ISSN: 0740-3194

Journal article

MALLOY CR, MATTHEWS PM, SMITH MB, RADDA GKet al., 1984, INFLUENCE OF PROPRANOLOL ON THE RESPONSE TO REGIONAL CARDIAC ISCHEMIA MONITORED INVIVO BY P-31 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY, CLINICAL RESEARCH, Vol: 32, Pages: A187-A187, ISSN: 0009-9279

Journal article

ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, APPLICATION OF P-31 NMR TO ASSESSMENT OF MITOCHONDRIAL-FUNCTION IN HUMAN SKELETAL-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 90-90, ISSN: 0740-3194

Journal article

MATTHEWS PM, BLAND JL, RADDA GK, 1983, THE TEMPERATURE-DEPENDENCE OF CREATINE-KINASE FLUXES IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 763, Pages: 140-146, ISSN: 0006-3002

Journal article

Matthews PM, Bland JJ, Radda GK, 1983, The temperature-dependence of steady-state creatine kinase fluxes in rat cardiac muscle, Biochemical Society Transactions, Vol: 11, Pages: 174-175, ISSN: 0300-5127

Journal article

THULBORN KR, WATERTON JC, MATTHEWS PM, RADDA GKet al., 1982, OXYGENATION DEPENDENCE OF THE TRANSVERSE RELAXATION-TIME OF WATER PROTONS IN WHOLE-BLOOD AT HIGH-FIELD, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 714, Pages: 265-270, ISSN: 0006-3002

Journal article

MATTHEWS PM, WILLIAMS SR, SEYMOUR AM, SCHWARTZ A, DUBE G, GADIAN DG, RADDA GKet al., 1982, A P-31-NMR STUDY OF SOME METABOLIC AND FUNCTIONAL-EFFECTS OF THE INOTROPIC AGENTS EPINEPHRINE AND OUABAIN, AND THE IONOPHORE RO2-2985 (X537A) IN THE ISOLATED, PERFUSED RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 720, Pages: 163-171, ISSN: 0006-3002

Journal article

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1982, A P-31-NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 721, Pages: 312-320, ISSN: 0006-3002

Journal article

Jennings RC, Gerola PD, Garlaschi FM, Giorgio Fet al., 1981, Studies of metabolism in the isolated, perfused rat heart using <sup>13</sup>C NMR, FEBS Letters, Vol: 123, Pages: 315-318, ISSN: 0014-5793

Journal article

Matthews PM, Radda GK, Taylor DJ, 1981, A <sup>31</sup>P n.m.r. study of metabolism in the hypoxic perfused rat heart, Biochemical Society Transactions, Vol: 9, Pages: 236-237, ISSN: 0300-5127

Journal article

BAILEY IA, GADIAN DG, MATTHEWS PM, RADDA GK, SEELEY PJet al., 1981, STUDIES OF METABOLISM IN THE ISOLATED, PERFUSED RAT-HEART USING C-13 NMR, FEBS LETTERS, Vol: 123, Pages: 315-318, ISSN: 0014-5793

Journal article

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1981, A 31-P NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE PERFUSED RAT-HEART, FEDERATION PROCEEDINGS, Vol: 40, Pages: 1625-1625, ISSN: 0014-9446

Journal article

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1981, THE STEADY-STATE RATE OF ATP SYNTHESIS IN THE PERFUSED RAT-HEART MEASURED BY P-31 NMR SATURATION TRANSFER, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 103, Pages: 1052-1059, ISSN: 0006-291X

Journal article

WILLIAMS SR, MATTHEWS PM, SCHWARTZ A, RADDA GKet al., 1980, THE RELATIONSHIP BETWEEN PRESSURE DEVELOPMENT INDUCED BY INOTROPIC AGENTS, AND HIGH-ENERGY PHOSPHATE-COMPOUNDS IN THE LANGENDORF (L) PERFUSED RAT-HEART - A P-31-NMR STUDY, FEDERATION PROCEEDINGS, Vol: 39, Pages: 2113-2113, ISSN: 0014-9446

Journal article

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