Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair, Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

610 results found

MATTHEWS PM, 1991, MYOTONIC-DYSTROPHY - OBSERVATIONS ON THE PHENOTYPE, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 49, Pages: 82-82, ISSN: 0002-9297

Journal article

MATTHEWS PM, FRANCIS G, ANTEL J, ARNOLD DLet al., 1991, PROTON MAGNETIC-RESONANCE SPECTROSCOPY FOR METABOLIC CHARACTERIZATION OF PLAQUES IN MULTIPLE-SCLEROSIS, NEUROLOGY, Vol: 41, Pages: 1251-1256, ISSN: 0028-3878

Journal article

MATTHEWS PM, TAMPIERI D, BERKOVIC SF, ANDERMANN F, SILVER K, CHITYAT D, ARNOLD DLet al., 1991, MAGNETIC-RESONANCE-IMAGING SHOWS SPECIFIC ABNORMALITIES IN THE MELAS SYNDROME, NEUROLOGY, Vol: 41, Pages: 1043-1046, ISSN: 0028-3878

Journal article

MATTHEWS PM, BERKOVIC SF, SHOUBRIDGE EA, ANDERMANN F, KARPATI G, CARPENTER S, ARNOLD DLet al., 1991, INVIVO MAGNETIC-RESONANCE SPECTROSCOPY OF BRAIN AND MUSCLE IN A TYPE OF MITOCHONDRIAL ENCEPHALOMYOPATHY (MERRF), ANNALS OF NEUROLOGY, Vol: 29, Pages: 435-438, ISSN: 0364-5134

Journal article

MATTHEWS PM, ALLAIRE C, SHOUBRIDGE EA, KARPATI G, CARPENTER S, ARNOLD DLet al., 1991, INVIVO MUSCLE MAGNETIC-RESONANCE SPECTROSCOPY IN THE CLINICAL INVESTIGATION OF MITOCHONDRIAL DISEASE, NEUROLOGY, Vol: 41, Pages: 114-120, ISSN: 0028-3878

Journal article

Rogers P, Matthews P, 1991, Western quality at a low price: Cleaning up in Poland?, European Management Journal, Vol: 9, Pages: 425-432, ISSN: 0263-2373

Poland's economic reform programme began on 1 January 1990 and has been radical and swift. The response from the West has been slower, but recently some major new joint ventures have been announced. Paul Rogers and Paul Matthews describe the attractive business opportunities that exist for West European companies in Poland, aided by huge markets, valuable production capacity to be acquired and a cheap, skilled workforce. But this is no place to make a fast buck; doing business is difficult when so much information and facilities are missing. Nonetheless, there are pressing reasons for acting now and getting a head start on the competition. © 1991.

Journal article

Arnold DL, Matthews PM, Francis G, Antel Jet al., 1991, Magnetic resonance spectroscopic imaging (MRSI) allows metabolic characterization of brain lesions, MedicaMundi, Vol: 36, Pages: 111-116, ISSN: 0025-7664

Recent developments in MR spectroscopy make it possible to create metabolic maps of the brain showing the regional distribution of metabolites. The data are displayed as MR spectroscopic images (MRSI), which are analogous to conventional MR images (MRI), except that the intensity of each voxel is based on the signal from a particular metabolite in the MR spectrum, rather than the intensity of the signal from water. The chemical data obtained can discriminate active demyelination from chronic gliosis, and determine the degree of irreversible injury to neurons and their processes, thus providing information not available from conventional MRI.

Journal article

KARPATI G, ARNOLD D, MATTHEWS P, CARPENTER S, ANDERMANN F, SHOUBRIDGE Eet al., 1991, CORRELATIVE MULTIDISCIPLINARY APPROACH TO THE STUDY OF MITOCHONDRIAL ENCEPHALOMYOPATHIES, Publisher: MASSON EDITEUR, Pages: 455-461, ISSN: 0035-3787

Conference paper

Matthews PM, Allaire C, Shoubridge EA, Karpati G, Carpenter S, Arnold DLet al., 1991, In vivo muscle magnetic resonance spectroscopy in the clinical investigation of mitochondrial disease., Neurology, Vol: 41, Pages: 114-120, ISSN: 0028-3878

We have investigated the sensitivity and specificity of a rapid phosphorus magnetic resonance spectroscopy (MRS) protocol for detecting metabolic abnormalities in vivo in skeletal muscle of patients with mitochondrial disease. We examined 17 patients with mitochondrial myopathies. Sixteen had only mild or minimal myopathic signs and symptoms. Phosphorus magnetic resonance spectra from the resting gastrocnemius muscles showed an abnormal intracellular energy state (marked by an increased intracellular inorganic phosphate concentration) in 14/17. In 3/17, this was associated with a decreased phosphocreatine concentration. We also studied 20 patients with other diseases of muscle (inflammatory myopathies, metabolic myopathies, muscular dystrophies, and myasthenia gravis) that can present with similar clinical features. Spectra showed increased intracellular inorganic phosphate concentrations in 6/20. All of these muscle diseases were associated with evidence of muscle fiber necrosis. Abnormalities in the muscle energy state in these cases may be due to secondary mitochondrial dysfunction. Except for cases of polymyositis and dermatomyositis, these 6 other myopathies could be readily distinguished from the mitochondrial myopathies on the basis of the clinical examination and blood tests. We conclude that phosphorus MRS of resting muscle is practical in a clinical setting and has a useful sensitivity and specificity for mitochondrial myopathies when used in conjunction with standard noninvasive tests.

Journal article

MATTHEWS PM, ARNOLD DL, 1990, PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY OF BRAIN IN MITOCHONDRIAL CYTOPATHIES, ANNALS OF NEUROLOGY, Vol: 28, Pages: 839-840, ISSN: 0364-5134

Journal article

MATTHEWS PM, ANDERMANN F, ARNOLD DL, 1990, A PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY OF FOCAL EPILEPSY IN HUMANS, NEUROLOGY, Vol: 40, Pages: 985-989, ISSN: 0028-3878

Journal article

ARNOLD DL, MATTHEWS PM, FRANCIS G, ANTEL Jet al., 1990, PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN INVIVO IN THE EVALUATION OF MULTIPLE-SCLEROSIS - ASSESSMENT OF THE LOAD OF DISEASE, MAGNETIC RESONANCE IN MEDICINE, Vol: 14, Pages: 154-159, ISSN: 0740-3194

Journal article

MATTHEWS PM, EVANS AC, ANDERMANN F, HAKIM AMet al., 1989, REGIONAL CEREBRAL GLUCOSE-METABOLISM DIFFERS IN ADULT AND RIGID JUVENILE FORMS OF HUNTINGTON DISEASE, PEDIATRIC NEUROLOGY, Vol: 5, Pages: 353-356, ISSN: 0887-8994

Journal article

MATTHEWS PM, SHOUBRIDGE E, ARNOLD DL, 1989, BRAIN PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE BACTERIAL-MENINGITIS, ARCHIVES OF NEUROLOGY, Vol: 46, Pages: 994-996, ISSN: 0003-9942

Journal article

MALLOY CR, MATTHEWS PM, SMITH MB, RADDA GKet al., 1986, INFLUENCE OF PROPRANOLOL ON ACIDOSIS AND HIGH-ENERGY PHOSPHATES IN ISCHEMIC MYOCARDIUM OF THE RABBIT, CARDIOVASCULAR RESEARCH, Vol: 20, Pages: 710-720, ISSN: 0008-6363

Journal article

TAYLOR DJ, MATTHEWS PM, RADDA GK, 1986, MYOGLOBIN-DEPENDENT OXIDATIVE-METABOLISM IN THE HYPOXIC RAT-HEART, RESPIRATION PHYSIOLOGY, Vol: 63, Pages: 275-283, ISSN: 0034-5687

Journal article

TAYLOR DJ, STYLES P, MATTHEWS PM, ARNOLD DA, GADIAN DG, BORE P, RADDA GKet al., 1986, ENERGETICS OF HUMAN-MUSCLE - EXERCISE-INDUCED ATP DEPLETION, MAGNETIC RESONANCE IN MEDICINE, Vol: 3, Pages: 44-54, ISSN: 0740-3194

Journal article

Malloy CR, Matthews PM, Smith MB, Radda GKet al., 1986, Influence of propranolol on acidosis and high energy phosphates in ischaemic myocardium of the rabbit, Cardiovascular Research, Vol: 20, Pages: 710-720, ISSN: 0008-6363

Journal article

MATTHEWS PM, TAYLOR DJ, RADDA GK, 1986, BIOCHEMICAL-MECHANISMS OF ACUTE CONTRACTILE FAILURE IN THE HYPOXIC RAT-HEART, CARDIOVASCULAR RESEARCH, Vol: 20, Pages: 13-19, ISSN: 0008-6363

Journal article

MATTHEWS PM, FOXALL D, SHEN LF, MANSOUR TEet al., 1986, NUCLEAR-MAGNETIC-RESONANCE STUDIES OF CARBOHYDRATE-METABOLISM AND SUBSTRATE CYCLING IN FASCIOLA-HEPATICA, MOLECULAR PHARMACOLOGY, Vol: 29, Pages: 65-73, ISSN: 0026-895X

Journal article

MATTHEWS PM, SHEN LF, FOXALL D, MANSOUR TEet al., 1985, P-31-NMR STUDIES OF METABOLITE COMPARTMENTATION IN FASCIOLA-HEPATICA, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 845, Pages: 178-188, ISSN: 0006-3002

Journal article

Malloy CR, Matthews PM, Smith MB, Radda GKet al., 1985, In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia., Adv Myocardiol, Vol: 6, Pages: 461-464, ISSN: 0270-4056

We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

Journal article

Keogh JM, Matthews PM, Seymour AM, Radda GKet al., 1985, A phosphorus-31 nuclear magnetic resonance study of effects of altered thyroid state on cardiac bioenergetics., Adv Myocardiol, Vol: 6, Pages: 299-309, ISSN: 0270-4056

We have used 31P nuclear magnetic resonance (NMR) techniques to characterize bioenergetic changes in the Langendorff-perfused rat heart accompanying alterations in thyroid state. Cytosolic phosphocreatine and inorganic phosphate concentrations changed significantly in both the hypo- and hyperthyroid groups compared to controls; the calculated phosphorylation potential [( ATP]/[ADP][Pi]) increased by 60% in hypothyroidism and decreased by 60% in hyperthyroidism relative to the euthyroid value of 47 X 10(3) M-1. Creatine phosphokinase (CPK) and mitochondrial ATP synthase rates were measured in the intact tissue using a saturation-transfer NMR method. There were no significant differences in the measured fluxes through the CPK reaction among the three groups (4.24 +/- 1.00 mM X sec-1 for the euthyroid group). Although O2 consumption increased by 46% in hearts from hyperthyroid animals, no change in the measured mitochondrial ATP synthase flux was observed compared to the euthyroid flux of 1.05 +/- 0.11 mM X sec-1. These results suggest that the apparent in situ P/O ratio of mitochondria in hearts from hyperthyroid animals is reduced relative to that in euthyroid controls.

Journal article

Shen L, Matthews PM, Foxall DL, Mansour TEet al., 1984, **3**1P NMR QUANTITATIVE STUDY OF THE LIVER FLUKE FASCIOLA HEPATICA., Pages: 473-474

Quantitative **3**1P spectra of intact Fasciola hepatica and their perchloric extracts were obtained under normal and sugar-depleted conditions. Resonances were identified and quantified.

Conference paper

ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, APPLICATION OF P-31 NMR TO ASSESSMENT OF MITOCHONDRIAL-FUNCTION IN HUMAN SKELETAL-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 90-90, ISSN: 0740-3194

Journal article

MALLOY CR, MATTHEWS PM, SMITH MB, RADDA GKet al., 1984, INFLUENCE OF PROPRANOLOL ON THE RESPONSE TO REGIONAL CARDIAC ISCHEMIA MONITORED INVIVO BY P-31 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY, CLINICAL RESEARCH, Vol: 32, Pages: A187-A187, ISSN: 0009-9279

Journal article

ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, METABOLIC RECOVERY AFTER EXERCISE AND THE ASSESSMENT OF MITOCHONDRIAL-FUNCTION INVIVO IN HUMAN SKELETAL-MUSCLE BY MEANS OF P-31 NMR, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 307-315, ISSN: 0740-3194

Journal article

RADDA GK, TAYLOR DJ, STYLES P, BORE PJ, MATTHEWS PM, GADIAN DGet al., 1984, EXERCISE-INDUCED ATP DEPLETION IN NORMAL HUMAN-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 229-229, ISSN: 0740-3194

Journal article

Matthews PM, Bland JJ, Radda GK, 1983, The temperature-dependence of steady-state creatine kinase fluxes in rat cardiac muscle, Biochemical Society Transactions, Vol: 11, Pages: 174-175, ISSN: 0300-5127

Journal article

MATTHEWS PM, BLAND JL, RADDA GK, 1983, THE TEMPERATURE-DEPENDENCE OF CREATINE-KINASE FLUXES IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 763, Pages: 140-146, ISSN: 0006-3002

Journal article

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