Professor Paul M. Matthews

TAYLOR DJ, MATTHEWS PM, RADDA GK, 1986, MYOGLOBIN-DEPENDENT OXIDATIVE-METABOLISM IN THE HYPOXIC RAT-HEART, RESPIRATION PHYSIOLOGY, Vol: 63, Pages: 275-283, ISSN: 0034-5687

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• Citations: 35

TAYLOR DJ, STYLES P, MATTHEWS PM, ARNOLD DA, GADIAN DG, BORE P, RADDA GKet al., 1986, ENERGETICS OF HUMAN-MUSCLE - EXERCISE-INDUCED ATP DEPLETION, MAGNETIC RESONANCE IN MEDICINE, Vol: 3, Pages: 44-54, ISSN: 0740-3194

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• Citations: 309

Malloy CR, Matthews PM, Smith MB, Radda GKet al., 1986, Influence of propranolol on acidosis and high energy phosphates in ischaemic myocardium of the rabbit, Cardiovascular Research, Vol: 20, Pages: 710-720, ISSN: 0008-6363

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• Citations: 23

MATTHEWS PM, TAYLOR DJ, RADDA GK, 1986, BIOCHEMICAL-MECHANISMS OF ACUTE CONTRACTILE FAILURE IN THE HYPOXIC RAT-HEART, CARDIOVASCULAR RESEARCH, Vol: 20, Pages: 13-19, ISSN: 0008-6363

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• Citations: 60

MATTHEWS PM, FOXALL D, SHEN LF, MANSOUR TEet al., 1986, NUCLEAR-MAGNETIC-RESONANCE STUDIES OF CARBOHYDRATE-METABOLISM AND SUBSTRATE CYCLING IN FASCIOLA-HEPATICA, MOLECULAR PHARMACOLOGY, Vol: 29, Pages: 65-73, ISSN: 0026-895X

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• Citations: 7

MATTHEWS PM, SHEN LF, FOXALL D, MANSOUR TEet al., 1985, P-31-NMR STUDIES OF METABOLITE COMPARTMENTATION IN FASCIOLA-HEPATICA, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 845, Pages: 178-188, ISSN: 0006-3002

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• Citations: 13

Malloy CR, Matthews PM, Smith MB, Radda GKet al., 1985, In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia., Adv Myocardiol, Vol: 6, Pages: 461-464, ISSN: 0270-4056

We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

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Keogh JM, Matthews PM, Seymour AM, Radda GKet al., 1985, A phosphorus-31 nuclear magnetic resonance study of effects of altered thyroid state on cardiac bioenergetics., Adv Myocardiol, Vol: 6, Pages: 299-309, ISSN: 0270-4056

We have used 31P nuclear magnetic resonance (NMR) techniques to characterize bioenergetic changes in the Langendorff-perfused rat heart accompanying alterations in thyroid state. Cytosolic phosphocreatine and inorganic phosphate concentrations changed significantly in both the hypo- and hyperthyroid groups compared to controls; the calculated phosphorylation potential [( ATP]/[ADP][Pi]) increased by 60% in hypothyroidism and decreased by 60% in hyperthyroidism relative to the euthyroid value of 47 X 10(3) M-1. Creatine phosphokinase (CPK) and mitochondrial ATP synthase rates were measured in the intact tissue using a saturation-transfer NMR method. There were no significant differences in the measured fluxes through the CPK reaction among the three groups (4.24 +/- 1.00 mM X sec-1 for the euthyroid group). Although O2 consumption increased by 46% in hearts from hyperthyroid animals, no change in the measured mitochondrial ATP synthase flux was observed compared to the euthyroid flux of 1.05 +/- 0.11 mM X sec-1. These results suggest that the apparent in situ P/O ratio of mitochondria in hearts from hyperthyroid animals is reduced relative to that in euthyroid controls.

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Shen L, Matthews PM, Foxall DL, Mansour TEet al., 1984, **3**1P NMR QUANTITATIVE STUDY OF THE LIVER FLUKE FASCIOLA HEPATICA., Pages: 473-474

Quantitative **3**1P spectra of intact Fasciola hepatica and their perchloric extracts were obtained under normal and sugar-depleted conditions. Resonances were identified and quantified.

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ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, METABOLIC RECOVERY AFTER EXERCISE AND THE ASSESSMENT OF MITOCHONDRIAL-FUNCTION INVIVO IN HUMAN SKELETAL-MUSCLE BY MEANS OF P-31 NMR, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 307-315, ISSN: 0740-3194

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• Citations: 429

RADDA GK, TAYLOR DJ, STYLES P, BORE PJ, MATTHEWS PM, GADIAN DGet al., 1984, EXERCISE-INDUCED ATP DEPLETION IN NORMAL HUMAN-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 229-229, ISSN: 0740-3194

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• Citations: 3

MALLOY CR, MATTHEWS PM, SMITH MB, RADDA GKet al., 1984, INFLUENCE OF PROPRANOLOL ON THE RESPONSE TO REGIONAL CARDIAC ISCHEMIA MONITORED INVIVO BY P-31 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY, CLINICAL RESEARCH, Vol: 32, Pages: A187-A187, ISSN: 0009-9279

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ARNOLD DL, MATTHEWS PM, RADDA GK, 1984, APPLICATION OF P-31 NMR TO ASSESSMENT OF MITOCHONDRIAL-FUNCTION IN HUMAN SKELETAL-MUSCLE, MAGNETIC RESONANCE IN MEDICINE, Vol: 1, Pages: 90-90, ISSN: 0740-3194

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MATTHEWS PM, BLAND JL, RADDA GK, 1983, THE TEMPERATURE-DEPENDENCE OF CREATINE-KINASE FLUXES IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 763, Pages: 140-146, ISSN: 0006-3002

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• Citations: 15

Matthews PM, Bland JJ, Radda GK, 1983, The temperature-dependence of steady-state creatine kinase fluxes in rat cardiac muscle, Biochemical Society Transactions, Vol: 11, Pages: 174-175, ISSN: 0300-5127

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• Citations: 1

THULBORN KR, WATERTON JC, MATTHEWS PM, RADDA GKet al., 1982, OXYGENATION DEPENDENCE OF THE TRANSVERSE RELAXATION-TIME OF WATER PROTONS IN WHOLE-BLOOD AT HIGH-FIELD, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 714, Pages: 265-270, ISSN: 0006-3002

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• Citations: 765

MATTHEWS PM, WILLIAMS SR, SEYMOUR AM, SCHWARTZ A, DUBE G, GADIAN DG, RADDA GKet al., 1982, A P-31-NMR STUDY OF SOME METABOLIC AND FUNCTIONAL-EFFECTS OF THE INOTROPIC AGENTS EPINEPHRINE AND OUABAIN, AND THE IONOPHORE RO2-2985 (X537A) IN THE ISOLATED, PERFUSED RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 720, Pages: 163-171, ISSN: 0006-3002

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• Citations: 90

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1982, A P-31-NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 721, Pages: 312-320, ISSN: 0006-3002

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• Citations: 153

Jennings RC, Gerola PD, Garlaschi FM, Giorgio Fet al., 1981, Studies of metabolism in the isolated, perfused rat heart using ¹³C NMR, FEBS Letters, Vol: 123, Pages: 315-318, ISSN: 0014-5793

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• Citations: 6

Matthews PM, Radda GK, Taylor DJ, 1981, A ³¹P n.m.r. study of metabolism in the hypoxic perfused rat heart, Biochemical Society Transactions, Vol: 9, Pages: 236-237, ISSN: 0300-5127

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• Citations: 27

BAILEY IA, GADIAN DG, MATTHEWS PM, RADDA GK, SEELEY PJet al., 1981, STUDIES OF METABOLISM IN THE ISOLATED, PERFUSED RAT-HEART USING C-13 NMR, FEBS LETTERS, Vol: 123, Pages: 315-318, ISSN: 0014-5793

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• Citations: 71

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1981, A 31-P NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE PERFUSED RAT-HEART, FEDERATION PROCEEDINGS, Vol: 40, Pages: 1625-1625, ISSN: 0014-9446

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• Citations: 1

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1981, THE STEADY-STATE RATE OF ATP SYNTHESIS IN THE PERFUSED RAT-HEART MEASURED BY P-31 NMR SATURATION TRANSFER, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 103, Pages: 1052-1059, ISSN: 0006-291X

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• Citations: 109

WILLIAMS SR, MATTHEWS PM, SCHWARTZ A, RADDA GKet al., 1980, THE RELATIONSHIP BETWEEN PRESSURE DEVELOPMENT INDUCED BY INOTROPIC AGENTS, AND HIGH-ENERGY PHOSPHATE-COMPOUNDS IN THE LANGENDORF (L) PERFUSED RAT-HEART - A P-31-NMR STUDY, FEDERATION PROCEEDINGS, Vol: 39, Pages: 2113-2113, ISSN: 0014-9446

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• Citations: 2