Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair, Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

612 results found

Matthews PM, Bland JJ, Radda GK, 1983, The temperature-dependence of steady-state creatine kinase fluxes in rat cardiac muscle, Biochemical Society Transactions, Vol: 11, Pages: 174-175, ISSN: 0300-5127

Journal article

MATTHEWS PM, BLAND JL, RADDA GK, 1983, THE TEMPERATURE-DEPENDENCE OF CREATINE-KINASE FLUXES IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 763, Pages: 140-146, ISSN: 0006-3002

Journal article

MATTHEWS PM, WILLIAMS SR, SEYMOUR AM, SCHWARTZ A, DUBE G, GADIAN DG, RADDA GKet al., 1982, A P-31-NMR STUDY OF SOME METABOLIC AND FUNCTIONAL-EFFECTS OF THE INOTROPIC AGENTS EPINEPHRINE AND OUABAIN, AND THE IONOPHORE RO2-2985 (X537A) IN THE ISOLATED, PERFUSED RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 720, Pages: 163-171, ISSN: 0006-3002

Journal article

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1982, A P-31-NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE RAT-HEART, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 721, Pages: 312-320, ISSN: 0006-3002

Journal article

THULBORN KR, WATERTON JC, MATTHEWS PM, RADDA GKet al., 1982, OXYGENATION DEPENDENCE OF THE TRANSVERSE RELAXATION-TIME OF WATER PROTONS IN WHOLE-BLOOD AT HIGH-FIELD, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 714, Pages: 265-270, ISSN: 0006-3002

Journal article

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1981, THE STEADY-STATE RATE OF ATP SYNTHESIS IN THE PERFUSED RAT-HEART MEASURED BY P-31 NMR SATURATION TRANSFER, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 103, Pages: 1052-1059, ISSN: 0006-291X

Journal article

MATTHEWS PM, BLAND JL, GADIAN DG, RADDA GKet al., 1981, A 31-P NMR SATURATION TRANSFER STUDY OF THE REGULATION OF CREATINE-KINASE IN THE PERFUSED RAT-HEART, FEDERATION PROCEEDINGS, Vol: 40, Pages: 1625-1625, ISSN: 0014-9446

Journal article

Matthews PM, Radda GK, Taylor DJ, 1981, A <sup>31</sup>P n.m.r. study of metabolism in the hypoxic perfused rat heart, Biochemical Society Transactions, Vol: 9, Pages: 236-237, ISSN: 0300-5127

Journal article

Jennings RC, Gerola PD, Garlaschi FM, Giorgio Fet al., 1981, Studies of metabolism in the isolated, perfused rat heart using <sup>13</sup>C NMR, FEBS Letters, Vol: 123, Pages: 315-318, ISSN: 0014-5793

Journal article

BAILEY IA, GADIAN DG, MATTHEWS PM, RADDA GK, SEELEY PJet al., 1981, STUDIES OF METABOLISM IN THE ISOLATED, PERFUSED RAT-HEART USING C-13 NMR, FEBS LETTERS, Vol: 123, Pages: 315-318, ISSN: 0014-5793

Journal article

WILLIAMS SR, MATTHEWS PM, SCHWARTZ A, RADDA GKet al., 1980, THE RELATIONSHIP BETWEEN PRESSURE DEVELOPMENT INDUCED BY INOTROPIC AGENTS, AND HIGH-ENERGY PHOSPHATE-COMPOUNDS IN THE LANGENDORF (L) PERFUSED RAT-HEART - A P-31-NMR STUDY, FEDERATION PROCEEDINGS, Vol: 39, Pages: 2113-2113, ISSN: 0014-9446

Journal article

Thrupp N, Frigerio CS, Wolfs L, Skene NG, Poovathingal S, Fourne Y, Matthews PM, Theys T, Mancuso R, de Strooper B, Fiers Met al., Single nucleus sequencing fails to detect microglial activation in human tissue

<jats:title>Abstract</jats:title><jats:p>Single nucleus RNA-Seq (snRNA-Seq) methods are used as an alternative to single cell RNA-Seq methods, as they allow transcriptomic profiling of frozen tissue. However, it is unclear whether snRNA-Seq is able to detect cellular state in human tissue. Indeed, snRNA-Seq analyses of human brain samples have failed to detect a consistent microglial activation signature in Alzheimer’s Disease. A comparison of microglia from single cells and single nuclei of four human subjects reveals that ~1% of genes is depleted in nuclei compared to whole cells. This small population contains 18% of genes previously implicated in microglial activation, including <jats:italic>APOE, CST3, FTL, SPP1</jats:italic>, and <jats:italic>CD74</jats:italic>. We confirm our findings across multiple previous single nucleus and single cell studies. Given the low sensitivity of snRNA-Seq to this population of activation genes, we conclude that snRNA-Seq is not suited to detecting cellular activation in microglia in human disease.</jats:p>

Journal article

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