Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

582 results found

Matthews PM, Hampshire A, 2016, Clinical Concepts Emerging from fMRI Functional Connectomics, NEURON, Vol: 91, Pages: 511-528, ISSN: 0896-6273

JOURNAL ARTICLE

De Guio F, Jouvent E, Biessels GJ, Black SE, Brayne C, Chen C, Cordonnier C, De Leeuw F-E, Dichgans M, Doubal F, Duering M, Dufouil C, Duzel E, Fazekas F, Hachinski V, Ikram MA, Linn J, Matthews PM, Mazoyer B, Mok V, Norrving B, O'Brien JT, Pantoni L, Ropele S, Sachdev P, Schmidt R, Seshadri S, Smith EE, Sposato LA, Stephan B, Swartz RH, Tzourio C, van Buchem M, van der Lugt A, van Oostenbrugge R, Vernooij MW, Viswanathan A, Werring D, Wollenweber F, Wardlaw JM, Chabriat Het al., 2016, Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 36, Pages: 1319-1337, ISSN: 0271-678X

JOURNAL ARTICLE

Matthews PM, Roncaroli F, Waldman A, Sormani MP, De Stefano N, Giovannoni G, Reynolds Ret al., 2016, A practical review of the neuropathology and neuroimaging of multiple sclerosis., Pract Neurol, Vol: 16, Pages: 279-287

The variability in the severity and clinical course of multiple sclerosis (MS) has as its basis an extreme heterogeneity in the location, nature and extent of pathology in the brain and spinal cord. Understanding the underlying neuropathology and associated pathogenetic mechanisms of the disease helps to communicate the rationale for treatment and disease monitoring to patients. Neuroimaging is an important tool for this: it allows clinicians to relate neuropathological changes to clinical presentations and to monitor the course of their disease. Here, we review MS neuropathology and its imaging correlates to provide a practical guide for using MRI to assess disease severity and treatment responses. This provides a foundation for optimal management of patients based on the principle that they show 'no evidence of disease activity'.

JOURNAL ARTICLE

Colasanti A, Guo Q, Giannetti P, Wall MB, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro PA, Malik O, Owen DR, Young AH, Gunn RN, Piccini P, Matthews PM, Rabiner EAet al., 2016, Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis, BIOLOGICAL PSYCHIATRY, Vol: 80, Pages: 62-72, ISSN: 0006-3223

JOURNAL ARTICLE

Poldrack R, Baker C, Durnez J, Gorgolewski K, Matthews P, Munafo M, Nichols T, Poline J-B, Vul E, Yarkoni Tet al., 2016, Scanning the Horizon: Towards transparent and reproducible neuroimaging research

Functional neuroimaging techniques have transformed our ability to probe the neurobiological basis of behaviour and are increasingly being applied by the wider neuroscience community. However, concerns have recently been raised that the conclusions drawn from some human neuroimaging studies are either spurious or not generalizable. Problems such as low statistical power, flexibility in data analysis, software errors, and lack of direct replication apply to many fields, but perhaps particularly to fMRI. Here we discuss these problems, outline current and suggested best practices, and describe how we think the field should evolve to produce the most meaningful answers to neuroscientific questions.

JOURNAL ARTICLE

Maron E, Near J, Wallis G, Stokes M, Matthews PM, Nutt DJet al., 2016, A pilot study of the effect of short-term escitalopram treatment on brain metabolites and gamma-oscillations in healthy subjects, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 30, Pages: 579-580, ISSN: 0269-8811

JOURNAL ARTICLE

Lovestone S, Rossor M, Gallacher J, Ritchie C, Burn D, Hyslop PSG, Mackay C, Matthews PM, Ballard C, Georges Jet al., 2016, Better together for better dementia research and care, LANCET PSYCHIATRY, Vol: 3, Pages: 503-504, ISSN: 2215-0374

JOURNAL ARTICLE

Comninos AN, Anastasovska J, Sahuri-Arisoylu M, Li X, Li S, Hu M, Jayasena CN, Ghatei MA, Bloom SR, Matthews PM, O'Byrne KT, Bell JD, Dhillo WSet al., 2016, Kisspeptin signaling in the amygdala modulates reproductive hormone secretion, BRAIN STRUCTURE & FUNCTION, Vol: 221, Pages: 2035-2047, ISSN: 1863-2653

JOURNAL ARTICLE

James A, Joyce E, Lunn D, Hough M, Kenny L, Ghataorhe P, Fernandez H, Matthews PM, Zarei Met al., 2016, Abnormal frontostriatal connectivity in adolescent-onset schizophrenia and its relationship to cognitive functioning, EUROPEAN PSYCHIATRY, Vol: 35, Pages: 32-38, ISSN: 0924-9338

JOURNAL ARTICLE

Tsinalis O, Matthews PM, Guo Y, 2016, Automatic Sleep Stage Scoring Using Time-Frequency Analysis and Stacked Sparse Autoencoders, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 44, Pages: 1587-1597, ISSN: 0090-6964

JOURNAL ARTICLE

Tiwari AD, Wu C, Zhu J, Zhang S, Zhu J, Wang WR, Zhang J, Tatsuoka C, Matthews PM, Miller RH, Wang Yet al., 2016, Design, Synthesis, and Evaluation of Fluorinated Radioligands for Myelin Imaging, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 59, Pages: 3705-3718, ISSN: 0022-2623

JOURNAL ARTICLE

Vera JH, Guo Q, Cole JH, Boasso A, Greathead L, Kelleher P, Rabiner EA, Kalk N, Bishop C, Gunn RN, Matthews PM, Winston Aet al., 2016, Neuroinflammation in treated HIV-positive individuals A TSPO PET study, NEUROLOGY, Vol: 86, Pages: 1425-1432, ISSN: 0028-3878

JOURNAL ARTICLE

Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJet al., 2016, Amyloid pathology and axonal injury after brain trauma, NEUROLOGY, Vol: 86, Pages: 821-828, ISSN: 0028-3878

JOURNAL ARTICLE

Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Chang S-H, Malik TH, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DOet al., 2016, Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Petersen SE, Matthews PM, Francis JM, Robson MD, Zemrak F, Boubertakh R, Young AA, Hudson S, Weale P, Garratt S, Collins R, Piechnik S, Neubauer Set al., 2016, UK Biobank's cardiovascular magnetic resonance protocol., Journal of Cardiovascular Magnetic Resonance, Vol: 18, ISSN: 1532-429X

BACKGROUND: UK Biobank's ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds. METHODS/DESIGN: We describe the CMR protocol applied in UK Biobank's pilot phase, which will be extended into the main phase with three centres using the same equipment and protocols. The CMR protocol includes white blood CMR (sagittal anatomy, coronary and transverse anatomy), cine CMR (long axis cines, short axis cines of the ventricles, coronal LVOT cine), strain CMR (tagging), flow CMR (aortic valve flow) and parametric CMR (native T1 map). DISCUSSION: This report will serve as a reference to researchers intending to use the UK Biobank resource or to replicate the UK Biobank cardiovascular magnetic resonance protocol in different settings.

JOURNAL ARTICLE

Miller KL, Bangerter N, Almagro FA, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Jenkinson M, Andersson J, Griffanti L, Weale P, Dragonu I, Garratt S, Hudson S, Collins R, Matthews PM, Smith SMet al., UK Biobank: Brain imaging protocols and first data release, ISMRM 24th Annual Meeting

CONFERENCE PAPER

Dong H, Matthews PM, Guo Y, 2016, A New Soft Material Based In-the-Ear EEG Recording Technique, 38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 5709-5712, ISSN: 1557-170X

CONFERENCE PAPER

Scott G, Gunn RN, Matthews PM, Sharp DJet al., 2016, Minocycline reduces microglial activation after traumatic brain injury measured using [11C]-PBR28 positron emission tomography, Publisher: TAYLOR & FRANCIS INC, Pages: 686-687, ISSN: 0269-9052

CONFERENCE PAPER

Maron E, Wall M, Norbury R, Godlewska B, Terbeck S, Cowen P, Matthews P, Nutt DJet al., 2016, Effect of short-term escitalopram treatment on neural activation during emotional processing, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 30, Pages: 33-39, ISSN: 0269-8811

JOURNAL ARTICLE

Matthews PM, Sudlow C, 2015, The UK Biobank, BRAIN, Vol: 138, Pages: 3463-3465, ISSN: 0006-8950

JOURNAL ARTICLE

Scott G, Hellyer PJ, Ramlackhansingh AF, Brooks DJ, Matthews PM, Sharp DJet al., 2015, Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage, JOURNAL OF NEUROINFLAMMATION, Vol: 12, ISSN: 1742-2094

JOURNAL ARTICLE

Matthews PM, 2015, New drugs and personalized medicine for multiple sclerosis, NATURE REVIEWS NEUROLOGY, Vol: 11, Pages: 614-616, ISSN: 1759-4758

JOURNAL ARTICLE

Matthews PM, 2015, Clinical applications of fMRI, fMRI: From Nuclear Spins to Brain Functions, Pages: 611-632, ISBN: 9781489975904

BOOK CHAPTER

Datta G, Battaglini M, Scott G, Yaldizli O, Ribeiro AS, Wall MB, Gunn R, Rabiner EA, Ciccarelli O, Nicholas R, Stefano ND, Matthews PMet al., 2015, Positron emission tomography imaging in multiple sclerosis highlights a diffuse inflammatory response in brain that appears normal on conventional magnetic resonance imaging, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 477-478, ISSN: 1352-4585

CONFERENCE PAPER

Matthews PM, 2015, Measuring brain function in multiple sclerosis, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 58-58, ISSN: 1352-4585

CONFERENCE PAPER

Colasanti A, Guo Q, Giannetti P, Wall M, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro P, Malik O, Owen D, Young AH, Gunn R, Piccini P, Matthews PM, Rabiner EAet al., 2015, Hippocampal inflammation and depression in multiple sclerosis: integrating evidence from TSPO PET and resting state fMRI, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 492-493, ISSN: 1352-4585

CONFERENCE PAPER

Suri S, Mackay CE, Kelly ME, Germuska M, Tunbridge EM, Frisoni GB, Matthews PM, Ebmeier KP, Bulte DP, Filippini Net al., 2015, Reduced cerebrovascular reactivity in young adults carrying the APOE epsilon 4 allele, ALZHEIMERS & DEMENTIA, Vol: 11, Pages: 648-657, ISSN: 1552-5260

JOURNAL ARTICLE

Ntusi NAB, Piechnik SK, Francis JM, Ferreira VM, Matthews PM, Robson MD, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Diffuse Myocardial Fibrosis and Inflammation in Rheumatoid Arthritis Insights From CMR T1 Mapping, JACC-CARDIOVASCULAR IMAGING, Vol: 8, Pages: 526-536, ISSN: 1936-878X

JOURNAL ARTICLE

Matthews PM, Datta G, 2015, Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis, EXPERT OPINION ON DRUG DISCOVERY, Vol: 10, Pages: 557-570, ISSN: 1746-0441

JOURNAL ARTICLE

Clarke E, Matthews PM, 2015, The OPTIMISE data project: toward improving multiple sclerosis treatment, FUTURE NEUROLOGY, Vol: 10, Pages: 187-190, ISSN: 1479-6708

JOURNAL ARTICLE

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