Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

576 results found

Paley C, Hull H, Ji Y, Toro-Ramos T, Thornton J, Bauer J, Matthews P, Yu A, Navder K, Dorsey K, Gallagher Det al., 2016, Body fat differences by self-reported race/ethnicity in healthy term newborns., Pediatr Obes, Vol: 11, Pages: 361-368

BACKGROUND: Ethnic differences in total body fat (fat mass [FM]) have been reported in adults and children, but the timing of when these differences manifest and whether they are present at birth are unknown. OBJECTIVES: This study aimed to assess whether ethnic differences in body fat are present at birth in healthy infants born at term, where body fat is measured using air displacement plethysmography and fat distribution by skin-fold thickness. METHODS: Data were from a multiracial cross-sectional convenience sample of 332 term infants from four racial or ethnic groups based on maternal self-report (A, Asian; AA, non-Hispanic Black [African-American]; C, non-Hispanic White; and H, Hispanic). The main outcome measure was infant body fat at 1-3 days after birth, with age, birth weight, gestational age and maternal pre-pregnancy weight as covariates. RESULTS: Significant effects for race (P = 0.0011), sex (P = 0.0051) and a race by sex interaction (P = 0.0236) were found. C females had higher FM than C males (P = 0.0001), and AA females had higher FM than AA males (P = 0.0205). C males had less FM than A males (P = 0.0353) and H males (P = 0.0001). CONCLUSION: Race/ethnic and sex differences in FM are present in healthy term newborns. Although the implications of these differences are unclear, studies beginning in utero and birth set the stage for a life course approach to understanding disease later in life.

JOURNAL ARTICLE

Petersen SE, Matthews PM, Francis JM, Robson MD, Zemrak F, Boubertakh R, Young AA, Hudson S, Weale P, Garratt S, Collins R, Piechnik S, Neubauer Set al., 2016, UK Biobank's cardiovascular magnetic resonance protocol., Journal of Cardiovascular Magnetic Resonance, Vol: 18, ISSN: 1532-429X

BACKGROUND: UK Biobank's ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds. METHODS/DESIGN: We describe the CMR protocol applied in UK Biobank's pilot phase, which will be extended into the main phase with three centres using the same equipment and protocols. The CMR protocol includes white blood CMR (sagittal anatomy, coronary and transverse anatomy), cine CMR (long axis cines, short axis cines of the ventricles, coronal LVOT cine), strain CMR (tagging), flow CMR (aortic valve flow) and parametric CMR (native T1 map). DISCUSSION: This report will serve as a reference to researchers intending to use the UK Biobank resource or to replicate the UK Biobank cardiovascular magnetic resonance protocol in different settings.

JOURNAL ARTICLE

Poldrack R, Baker C, Durnez J, Gorgolewski K, Matthews P, Munafo M, Nichols T, Poline J-B, Vul E, Yarkoni Tet al., 2016, Scanning the Horizon: Towards transparent and reproducible neuroimaging research

Functional neuroimaging techniques have transformed our ability to probe the neurobiological basis of behaviour and are increasingly being applied by the wider neuroscience community. However, concerns have recently been raised that the conclusions drawn from some human neuroimaging studies are either spurious or not generalizable. Problems such as low statistical power, flexibility in data analysis, software errors, and lack of direct replication apply to many fields, but perhaps particularly to fMRI. Here we discuss these problems, outline current and suggested best practices, and describe how we think the field should evolve to produce the most meaningful answers to neuroscientific questions.

JOURNAL ARTICLE

Ricotti V, Evans MRB, Sinclair CDJ, Butler JW, Ridout DA, Hogrel J-Y, Emira A, Morrow JM, Reilly MM, Hanna MG, Janiczek RL, Matthews PM, Yousry TA, Muntoni F, Thornton JSet al., 2016, Upper Limb Evaluation in Duchenne Muscular Dystrophy: Fat-Water Quantification by MRI, Muscle Force and Function Define Endpoints for Clinical Trials, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Russo EA, Khan S, Janisch R, Gunn RN, Rabiner EA, Taylor SA, Matthews PM, Orchard TRet al., 2016, Role of F-18-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohn's Disease, INFLAMMATORY BOWEL DISEASES, Vol: 22, Pages: 2619-2629, ISSN: 1078-0998

JOURNAL ARTICLE

Scott G, Gunn RN, Matthews PM, Sharp DJet al., 2016, Minocycline reduces microglial activation after traumatic brain injury measured using [11C]-PBR28 positron emission tomography, Publisher: TAYLOR & FRANCIS INC, Pages: 686-687, ISSN: 0269-9052

CONFERENCE PAPER

Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJet al., 2016, Amyloid pathology and axonal injury after brain trauma, NEUROLOGY, Vol: 86, Pages: 821-828, ISSN: 0028-3878

JOURNAL ARTICLE

Tiwari AD, Wu C, Zhu J, Zhang S, Zhu J, Wang WR, Zhang J, Tatsuoka C, Matthews PM, Miller RH, Wang Yet al., 2016, Design, Synthesis, and Evaluation of Fluorinated Radioligands for Myelin Imaging, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 59, Pages: 3705-3718, ISSN: 0022-2623

JOURNAL ARTICLE

Tsinalis O, Matthews PM, Guo Y, 2016, Automatic Sleep Stage Scoring Using Time-Frequency Analysis and Stacked Sparse Autoencoders, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 44, Pages: 1587-1597, ISSN: 0090-6964

JOURNAL ARTICLE

Vera JH, Guo Q, Cole JH, Boasso A, Greathead L, Kelleher P, Rabiner EA, Kalk N, Bishop C, Gunn RN, Matthews PM, Winston Aet al., 2016, Neuroinflammation in treated HIV-positive individuals A TSPO PET study, NEUROLOGY, Vol: 86, Pages: 1425-1432, ISSN: 0028-3878

JOURNAL ARTICLE

Clarke E, Matthews PM, 2015, The OPTIMISE data project: toward improving multiple sclerosis treatment, FUTURE NEUROLOGY, Vol: 10, Pages: 187-190, ISSN: 1479-6708

JOURNAL ARTICLE

Colasanti A, Guo Q, Giannetti P, Wall M, Bishop C, Newbould R, Owen D, Young AH, Gunn R, Piccini P, Matthews PM, Rabiner Iet al., 2015, Hippocampal Inflammation and Depressive Symptoms are Associated to the Strength of Hippocampal Functional Connectivity in Multiple Sclerosis: A Study with TSPO-PET and Resting-State fMRI, 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology, Publisher: ELSEVIER SCIENCE INC, Pages: 115S-116S, ISSN: 0006-3223

CONFERENCE PAPER

Colasanti A, Guo Q, Giannetti P, Wall M, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro P, Malik O, Owen D, Young AH, Gunn R, Piccini P, Matthews PM, Rabiner EAet al., 2015, Hippocampal inflammation and depression in multiple sclerosis: integrating evidence from TSPO PET and resting state fMRI, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 492-493, ISSN: 1352-4585

CONFERENCE PAPER

Datta G, Battaglini M, Scott G, Yaldizli O, Ribeiro AS, Wall MB, Gunn R, Rabiner EA, Ciccarelli O, Nicholas R, Stefano ND, Matthews PMet al., 2015, Positron emission tomography imaging in multiple sclerosis highlights a diffuse inflammatory response in brain that appears normal on conventional magnetic resonance imaging, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 477-478, ISSN: 1352-4585

CONFERENCE PAPER

Jacobs HIL, Wiese S, van de Ven V, Gronenschild EHBM, Verhey FRJ, Matthews PMet al., 2015, Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia, NEUROBIOLOGY OF AGING, Vol: 36, Pages: 618-626, ISSN: 0197-4580

JOURNAL ARTICLE

Matthews PM, 2015, New drugs and personalized medicine for multiple sclerosis, NATURE REVIEWS NEUROLOGY, Vol: 11, Pages: 614-616, ISSN: 1759-4758

JOURNAL ARTICLE

Matthews PM, 2015, Measuring brain function in multiple sclerosis, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 58-58, ISSN: 1352-4585

CONFERENCE PAPER

Matthews PM, 2015, Professor Paul Matthews talks 'big data' within multiple sclerosis., Neurodegener Dis Manag, Vol: 5, Pages: 101-104

JOURNAL ARTICLE

Matthews PM, 2015, Clinical applications of fMRI, fMRI: From Nuclear Spins to Brain Functions, Pages: 611-632, ISBN: 9781489975911

BOOK CHAPTER

Matthews PM, Datta G, 2015, Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis, EXPERT OPINION ON DRUG DISCOVERY, Vol: 10, Pages: 557-570, ISSN: 1746-0441

JOURNAL ARTICLE

Matthews PM, Sudlow C, 2015, The UK Biobank, BRAIN, Vol: 138, Pages: 3463-3465, ISSN: 0006-8950

JOURNAL ARTICLE

Nie L, Yang X, Matthews PM, Xu Z, Guo Yet al., 2015, Minimum Partial Correlation: An Accurate and Parameter-Free Measure of Functional Connectivity in fMRI, 8th International Conference on Brain Informatics and Health (BIH), Publisher: SPRINGER-VERLAG BERLIN, Pages: 125-134, ISSN: 0302-9743

CONFERENCE PAPER

Ntusi NA, Holloway C, Francis JM, Davis A, Levelt E, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Karamitsos TD, Neubauer Set al., 2015, Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: A phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

JOURNAL ARTICLE

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

JOURNAL ARTICLE

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Impaired myocardial perfusion in rheumatoid arthritis is associated with impaired strain, strain rate, disease activity and myocardial oedema: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

JOURNAL ARTICLE

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

JOURNAL ARTICLE

Ntusi NAB, Piechnik SK, Francis JM, Ferreira VM, Matthews PM, Robson MD, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Diffuse Myocardial Fibrosis and Inflammation in Rheumatoid Arthritis Insights From CMR T1 Mapping, JACC-CARDIOVASCULAR IMAGING, Vol: 8, Pages: 526-536, ISSN: 1936-878X

JOURNAL ARTICLE

Scott G, Hellyer PJ, Ramlackhansingh AF, Brooks DJ, Matthews PM, Sharp DJet al., 2015, Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage, JOURNAL OF NEUROINFLAMMATION, Vol: 12, ISSN: 1742-2094

JOURNAL ARTICLE

Shields GS, Coissi GS, Jimenez-Royo P, Gambarota G, Dimber R, Hopkinson NS, Matthews PM, Brown AP, Polkey MIet al., 2015, BIOENERGETICS AND INTERMUSCULAR FAT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE-ASSOCIATED QUADRICEPS WEAKNESS, MUSCLE & NERVE, Vol: 51, Pages: 214-221, ISSN: 0148-639X

JOURNAL ARTICLE

Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, Liu B, Matthews P, Ong G, Pell J, Silman A, Young A, Sprosen T, Peakman T, Collins Ret al., 2015, UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age, PLOS MEDICINE, Vol: 12, ISSN: 1549-1676

JOURNAL ARTICLE

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