Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department
 
 
 
//

Contact

 

+44 (0)20 7594 2855p.matthews

 
 
//

Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
//

Location

 

E502Burlington DanesHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

594 results found

Nie L, Yang X, Matthews P, Xu Z, Guo Yet al., 2015, Minimum Partial Correlation: An Accurate and Parameter-Free Measure of Functional Connectivity in fMRI, International Conference on Brain Informatics & Health, BIH, Publisher: Springer International Publishing

Conference paper

Matthews PM, 2015, Clinical applications of fMRI, fMRI: From Nuclear Spins to Brain Functions, Pages: 611-632, ISBN: 9781489975904

Book chapter

Datta G, Battaglini M, Scott G, Yaldizli O, Ribeiro AS, Wall MB, Gunn R, Rabiner EA, Ciccarelli O, Nicholas R, Stefano ND, Matthews PMet al., 2015, Positron emission tomography imaging in multiple sclerosis highlights a diffuse inflammatory response in brain that appears normal on conventional magnetic resonance imaging, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE Publications (UK and US), Pages: 477-478, ISSN: 1477-0970

Conference paper

Matthews PM, 2015, Measuring brain function in multiple sclerosis, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 58-58, ISSN: 1352-4585

Conference paper

Colasanti A, Guo Q, Giannetti P, Wall M, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro P, Malik O, Owen D, Young AH, Gunn R, Piccini P, Matthews PM, Rabiner EAet al., 2015, Hippocampal inflammation and depression in multiple sclerosis: integrating evidence from TSPO PET and resting state fMRI, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE Publications (UK and US), Pages: 492-493, ISSN: 1477-0970

Conference paper

Suri S, Mackay CE, Kelly ME, Germuska M, Tunbridge EM, Frisoni GB, Matthews PM, Ebmeier KP, Bulte DP, Filippini Net al., 2015, Reduced cerebrovascular reactivity in young adults carrying the APOE epsilon 4 allele, ALZHEIMERS & DEMENTIA, Vol: 11, Pages: 648-657, ISSN: 1552-5260

Journal article

Ntusi NAB, Piechnik SK, Francis JM, Ferreira VM, Matthews PM, Robson MD, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Diffuse Myocardial Fibrosis and Inflammation in Rheumatoid Arthritis Insights From CMR T1 Mapping, JACC-CARDIOVASCULAR IMAGING, Vol: 8, Pages: 526-536, ISSN: 1936-878X

Journal article

Colasanti A, Guo Q, Giannetti P, Wall M, Bishop C, Newbould R, Owen D, Young AH, Gunn R, Piccini P, Matthews PM, Rabiner Iet al., 2015, Hippocampal Inflammation and Depressive Symptoms are Associated to the Strength of Hippocampal Functional Connectivity in Multiple Sclerosis: A Study with TSPO-PET and Resting-State fMRI, 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology, Publisher: ELSEVIER SCIENCE INC, Pages: 115S-116S, ISSN: 0006-3223

Conference paper

Clarke E, Matthews PM, 2015, The OPTIMISE data project: toward improving multiple sclerosis treatment, FUTURE NEUROLOGY, Vol: 10, Pages: 187-190, ISSN: 1479-6708

Journal article

Matthews PM, Datta G, 2015, Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis, EXPERT OPINION ON DRUG DISCOVERY, Vol: 10, Pages: 557-570, ISSN: 1746-0441

Journal article

Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, Liu B, Matthews P, Ong G, Pell J, Silman A, Young A, Sprosen T, Peakman T, Collins Ret al., 2015, UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age, PLOS Medicine, Vol: 12, ISSN: 1549-1277

UK Biobank is a very large and detailed prospective study with over 500,000 participantsaged 40–69 years when recruited in 2006–2010.• The study has collected and continues to collect extensive phenotypic and genotypic detailabout its participants, including data from questionnaires, physical measures, sampleassays, accelerometry, multimodal imaging, genome-wide genotyping and longitudinalfollow-up for a wide range of health-related outcomes.• Wide consultation; input from scientific, management, legal, and ethical partners; andindustrial-scale, centralised processes have been essential to the development ofthis resource.• UK Biobank is available for open access, without the need for collaboration, to any bonafide researcher who wishes to use it to conduct health-related research for the benefit ofthe public.

Journal article

Comninos AN, Anastasovska J, Sahuri-Arisoylu M, Li X, Li S, Hu M, Jayasena CN, Ghatei MA, Bloom SR, Matthews PM, O'Byrne KT, Bell JD, Dhillo WSet al., 2015, Kisspeptin signaling in the amygdala modulates reproductive hormone secretion, Brain Structure & Function, Vol: 221, Pages: 2035-2047, ISSN: 1863-2661

Kisspeptin (encoded by KISS1) is a crucial activator of reproductive function. The role of kisspeptin has been studied extensively within the hypothalamus but little is known about its significance in other areas of the brain. KISS1 and its cognate receptor are expressed in the amygdala, a key limbic brain structure with inhibitory projections to hypothalamic centers involved in gonadotropin secretion. We therefore hypothesized that kisspeptin has effects on neuronal activation and reproductive pathways beyond the hypothalamus and particularly within the amygdala. To test this, we mapped brain neuronal activity (using manganese-enhanced MRI) associated with peripheral kisspeptin administration in rodents. We also investigated functional relevance by measuring the gonadotropin response to direct intra-medial amygdala (MeA) administration of kisspeptin and kisspeptin antagonist. Peripheral kisspeptin administration resulted in a marked decrease in signal intensity in the amygdala compared to vehicle alone. This was associated with an increase in luteinizing hormone (LH) secretion. In addition, intra-MeA administration of kisspeptin resulted in increased LH secretion, while blocking endogenous kisspeptin signaling within the amygdala by administering intra-MeA kisspeptin antagonist decreased both LH secretion and LH pulse frequency. We provide evidence for the first time that neuronal activity within the amygdala is decreased by peripheral kisspeptin administration and that kisspeptin signaling within the amygdala contributes to the modulation of gonadotropin release and pulsatility. Our data suggest that kisspeptin is a ‘master regulator’ of reproductive physiology, integrating limbic circuits with the regulation of gonadotropin-releasing hormone neurons and reproductive hormone secretion.

Journal article

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Impaired myocardial perfusion in rheumatoid arthritis is associated with impaired strain, strain rate, disease activity and myocardial oedema: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Ntusi NA, Holloway C, Francis JM, Davis A, Levelt E, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Karamitsos TD, Neubauer Set al., 2015, Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: A phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Jacobs HIL, Wiese S, van de Ven V, Gronenschild EHBM, Verhey FRJ, Matthews PMet al., 2015, Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia, NEUROBIOLOGY OF AGING, Vol: 36, Pages: 618-626, ISSN: 0197-4580

Journal article

Shields GS, Coissi GS, Jimenez-Royo P, Gambarota G, Dimber R, Hopkinson NS, Matthews PM, Brown AP, Polkey MIet al., 2015, BIOENERGETICS AND INTERMUSCULAR FAT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE-ASSOCIATED QUADRICEPS WEAKNESS, MUSCLE & NERVE, Vol: 51, Pages: 214-221, ISSN: 0148-639X

Journal article

Yang X, Nie L, Matthews PM, Tomassini V, Xu Z, Guo Yet al., 2015, The critical regularization value: incorporating spatial smoothness to enhance signal detection in highly noisy fMRI data, 7th Annual International IEEE EMBS Conference on Neural Engineering (NER), Publisher: IEEE, Pages: 1076-1079, ISSN: 1948-3546

Conference paper

Matthews PM, 2015, Professor Paul Matthews talks 'big data' within multiple sclerosis., Neurodegener Dis Manag, Vol: 5, Pages: 101-104

Journal article

Douaud G, Groves AR, Tamnes CK, Westlye LT, Duff EP, Engvig A, Walhovd KB, James A, Gass A, Monsch AU, Matthews PM, Fjell AM, Smith SM, Johansen-Berg Het al., 2014, A common brain network links development, aging, and vulnerability to disease, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 17648-17653, ISSN: 0027-8424

Journal article

Bishop CA, Ricotti V, Sinclair CDJ, Butler J, Evans RBM, Morrow JM, Hanna MG, Matthews PM, Yousry TA, Thornton JS, Muntoni F, Janiczek RLet al., 2014, Semi-automated analysis of diaphragmatic motion during deep breathing using dynamic MRI in both healthy controls and non-ambulant Duchenne muscular dystrophy, 19th International Congress of the World-Muscle-Society, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 852-853, ISSN: 0960-8966

Conference paper

Linortner P, Jehna M, Johansen-Berg H, Matthews PM, Schmidt R, Fazekas F, Enzinger Cet al., 2014, Aging associated changes in the motor control of ankle movements in the brain, NEUROBIOLOGY OF AGING, Vol: 35, Pages: 2222-2229, ISSN: 0197-4580

Journal article

Ntusi NAB, Sever E, Lockey J, Francis JM, Matthews PM, Wordsworth BP, Neubauer S, Karamitsos TDet al., 2014, Myocardial perfusion reserve is associated with impaired strain and higher disease activity in rheumatoid arthritis: cardiovascular magnetic resonance study, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 796-796, ISSN: 0195-668X

Conference paper

Colasanti A, Guo Q, Muhlert N, Giannetti P, Onega M, Newbould RD, Ciccarelli O, Rison S, Thomas C, Nicholas R, Muraro PA, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner EA, Matthews PMet al., 2014, In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with F-18-PBR111 PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 1112-1118, ISSN: 0161-5505

Journal article

Owen DR, Guo Q, Kalk NJ, Colasanti A, Kalogiannopoulou D, Dimber R, Lewis YL, Libri V, Barletta J, Ramada-Magalhaes J, Kamalakaran A, Nutt DJ, Passchier J, Matthews PM, Gunn RN, Rabiner EAet al., 2014, Determination of [C-11]PBR28 binding potential in vivo: a first human TSPO blocking study (vol 34, pg 1256, 2014), JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 34, Pages: 1256-1256, ISSN: 0271-678X

Journal article

Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DOet al., 2014, DEVELOPMENT OF WHOLE BODY AND INTRAVASCULAR NEAR-INFRARED OPTICAL MOLECULAR IMAGING OF MARKERS OF PLAQUE VULNERABLITY IN ATHEROSCLEROSIS, Annual Conference of the British-Cardiovascular-Society

Poster

Battaglini M, Rossi F, Grove RA, Stromillo ML, Whitcher B, Matthews PM, De Stefano Net al., 2014, Automated Identification of Brain New Lesions in Multiple Sclerosis Using Subtraction Images, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 39, Pages: 1543-1549, ISSN: 1053-1807

Journal article

Russo E, Khan S, Brown AP, Keat N, Hallett W, Janisch R, Gunn RN, Rabiner EA, Matthews PM, Orchard TRet al., 2014, CORRELATION OF FDG PET SCANNING WITH ENDOSCOPIC FINDINGS IN PATIENTS WITH CROHN'S DISEASE, GUT, Vol: 63, Pages: A74-A74, ISSN: 0017-5749

Journal article

Colasanti A, Guo Q, Giannetti P, Onega M, Owen DR, Piccini P, Gunn RN, Matthews PM, Rabiner EAet al., 2014, TSPO-targeted PET Imaging Suggests Increased Microglia Activation in Multiple Sclerosis Hippocampus is Correlated to Depressive Symptomatology, 69th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry, Publisher: ELSEVIER SCIENCE INC, Pages: 94S-95S, ISSN: 0006-3223

Conference paper

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00501273&limit=30&person=true&page=4&respub-action=search.html