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Matthews PM, Coatney R, Alsaid H, et al., 2013, Technologies: preclinical imaging for drug development., Drug Discov Today Technol, Vol: 10, Pages: e343-e350
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography (CT), ultrasound (US), positron emission tomography (PET) or single-photon emission computed tomography (SPECT) enable non-invasive measures of tissue structure, function or metabolism in vivo. The technologies can add value to preclinical studies by enabling dynamic pharmacological observations on the same animal and because of possibilities for relatively direct clinical translation. Potential benefits from the application of preclinical imaging should be considered routinely in drug development.
Newbould RD, Miller SR, Upadhyay N, et al., 2013, T1-Weighted Sodium MRI of the Articulator Cartilage in Osteoarthritis: A Cross Sectional and Longitudinal Study, PLOS ONE, Vol: 8, ISSN: 1932-6203
Khamis R, Woollard K, Chang SH, et al., 2013, The Near Infra-Red (NIRF) molecular imaging of oxidised LDL in atherosclerosis with the native autoantibody LO1, and its molecularly expressed cysteine-tagged Fab construct (LO1-Fab-cys), Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 29-29, ISSN: 0195-668X
Petersen SE, Matthews PM, Bamberg F, et al., 2013, Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 15, ISSN: 1097-6647
Ntusi NBA, Francis JM, Matthews PM, et al., 2013, SYSTEMIC LUPUS ERYTHEMATOSUS IS ASSOCIATED WITH IMPAIRED MYOCARDIAL STRAIN AND VASCULAR FUNCTION, INCREMENTAL TO THAT CAUSED BY TRADITIONAL RISK FACTORS: A CARDIOVASCULAR MAGNETIC RESONANCE STUDY, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037
Ntusi NBA, Francis JM, Matthews PM, et al., 2013, MYOCARDIAL AND VASCULAR DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS ASSESSED WITH CARDIOVASCULAR MAGNETIC RESONANCE: EVIDENCE OF INCREASED VASCULAR RISK, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, Pages: A61-U238, ISSN: 1355-6037
Khamis R, Woollard K, Granger D, et al., 2013, IMAGING BEYOND THE LUMEN: NEAR INFRA-RED IN VIVO MOLECULAR IDENTIFICATION OF OXIDISED LDL IN ATHEROSCLEROSIS USING MAB LO1, AND THE GENERATION AND DEVELOPMENT OF ITS MOLECULARLY EXPRESSED CYSTEINE-TAGGED CHIMERIC FAB CONSTRUCT (LO1-FAB-CYS), Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037
Gourraud P-A, Sdika M, Khankhanian P, et al., 2013, A genome-wide association study of brain lesion distribution in multiple sclerosis, BRAIN, Vol: 136, Pages: 1012-1024, ISSN: 0006-8950
Matthews PM, Matthews EA, 2013, Expanding perception through the disordered brain., Lancet, Vol: 381, Pages: 985-986
Strijbis EMM, Inkster B, Vounou M, et al., 2013, Glutamate gene polymorphisms predict brain volumes in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 19, Pages: 281-288, ISSN: 1352-4585
Zarei M, Beckmann CF, Binnewijzend MAA, et al., 2013, Functional segmentation of the hippocampus in the healthy human brain and in Alzheimer's disease, NEUROIMAGE, Vol: 66, Pages: 28-35, ISSN: 1053-8119
Douaud G, Menke RAL, Gass A, et al., 2013, Brain Microstructure Reveals Early Abnormalities more than Two Years prior to Clinical Progression from Mild Cognitive Impairment to Alzheimer's Disease, JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 2147-2155, ISSN: 0270-6474
Inkster B, Strijbis EMM, Vounou M, et al., 2013, Histone deacetylase gene variants predict brain volume changes in multiple sclerosis, NEUROBIOLOGY OF AGING, Vol: 34, Pages: 238-247, ISSN: 0197-4580
Matthews PM, Filippini N, Douaud G, 2013, Brain Structural and Functional Connectivity and the Progression of Neuropathology in Alzheimer's Disease, JOURNAL OF ALZHEIMERS DISEASE, Vol: 33, Pages: S163-S172, ISSN: 1387-2877
Libri V, Brown AP, Gambarota G, et al., 2012, A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers, PLOS ONE, Vol: 7, ISSN: 1932-6203
Matthews PM, Filippini N, Douaud G, 2012, Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease, ISBN: 9781614991533
In our contribution to this special issue focusing on advances in Alzheimer's disease (AD) research since the centennial, we will briefly review some of our own studies applying magnetic resonance imaging (MRI) measures of function and connectivity for characterization of genetic contributions to the neuropathology of AD and as candidate biomarkers. We review how functional MRI during both memory encoding and at rest is able to define APOE4 genotype-dependent physiological changes decades before potential development of AD and demonstrate changes distinct from those with healthy aging. More generally, imaging provides a powerful quantitative measure of phenotype for understanding associations arising from whole genome studies in AD. Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. We illustrate applications of DTI for more finely mapping neurodegenerative changes with AD in the thalamus in vivo and for defining neuropathological changes in the white matter itself. The latter efforts have highlighted how sensitivity to the neuropathology can be enhanced by using more specific DTI measures and interpreting them relative to knowledge of local white matter anatomy in the healthy brain. Together, our studies and related work are helping to establish the exciting potential of a new range of MRI methods as neuropathological measures and as biomarkers of disease progression. © 2013 The authors and IOS Press. All rights reserved.
Cole DM, Beckmann CF, Searle GE, et al., 2012, Orbitofrontal Connectivity with Resting-State Networks Is Associated with Midbrain Dopamine D3 Receptor Availability, CEREBRAL CORTEX, Vol: 22, Pages: 2784-2793, ISSN: 1047-3211
Gelineau-Morel R, Tomassini V, Jenkinson M, et al., 2012, The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis, HUMAN BRAIN MAPPING, Vol: 33, Pages: 2802-2814, ISSN: 1065-9471
Tomassini V, Matthews PM, Thompson AJ, et al., 2012, Neuroplasticity and functional recovery in multiple sclerosis, NATURE REVIEWS NEUROLOGY, Vol: 8, Pages: 635-646, ISSN: 1759-4758
Fleming IN, Whelan M, Baxendale R, et al., 2012, Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 33, Pages: 899-906, ISSN: 0143-3636
Colasanti A, Searle GE, Long CJ, et al., 2012, Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration, BIOLOGICAL PSYCHIATRY, Vol: 72, Pages: 371-377, ISSN: 0006-3223
Allen N, Sudlow C, Downey P, et al., 2012, UK Biobank: Current status and what it means for epidemiology, HEALTH POLICY AND TECHNOLOGY, Vol: 1, Pages: 123-126, ISSN: 2211-8837
, 2012, Clinical imaging in drug development, Drug Discovery and Development: Technology in Transition, Pages: 259-274, ISBN: 9780702053160
Colasanti A, Guo Q, Onega M, et al., 2012, [F-18]PBR111 binding in multiple sclerosis: relationship to age and clinical variables, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S22-S22, ISSN: 0271-678X
Politis M, Giannetti P, Su P, et al., 2012, Increased PK11195 PET binding in the cortex of patients with MS correlates with disability, NEUROLOGY, Vol: 79, Pages: 523-530, ISSN: 0028-3878
Tomassini V, Johansen-Berg H, Jbabdi S, et al., 2012, Relating Brain Damage to Brain Plasticity in Patients With Multiple Sclerosis, NEUROREHABILITATION AND NEURAL REPAIR, Vol: 26, Pages: 581-593, ISSN: 1545-9683
Newbould RD, Miller SR, Toms LD, et al., 2012, T2* measurement of the knee articular cartilage in osteoarthritis at 3T, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 35, Pages: 1422-1429, ISSN: 1053-1807
Matthews PM, 2012, An introduction to functional magnetic resonance imaging of the brain, Functional Magnetic Resonance Imaging: An Introduction to Methods, ISBN: 9780191724770
© Oxford University Press 2001. All rights reserved. This chapter provides an overview of functional magnetic resonance imaging (fMRI) methods and applications, highlighting key concepts and strategies, and includes the full range of techniques by which physiological changes accompanying brain activity are defined. It focuses on the changes in blood oxygenation and flow that have been used for the functional magnetic resonance imaging methods. Direct imaging of the blood flow response using perfusion MRI is also discussed. The study furthermore deals with elegant methods that have been developed and allow an extension of this simple concept for one-dimensional imaging into methods for multi-slice two-dimensional or threedimensional imaging. It outlines the major issues in statistical analysis for fMRI and addresses ways in which the data can be prepared for analysis to minimize artefacts and maximize sensitivity for the detection of activation changes. Finally, the chapter discusses the various applications of fMRI in neuroscience.
Jezzard P, Matthews PM, Smith SM, 2012, Functional magnetic resonance imaging: An introduction to methods, ISBN: 9780191724770
© Oxford University Press 2001. All rights reserved. This book provides an introduction to functional magnetic resonance imaging (fMRI), the scanning technique that allows the mapping of active processes within the brain. There are six sections to the book, with chapters from an international team. Part I provides a broad overview of the field and sets the context. Part II describes the physiological and physical background to fMRI, including coverage of the hardware required and pulse-sequence selection. Practical issues involving experimental design of the paradigms, psycho-physical stimulus delivery, and subject response are covered in Part III, followed by a comprehensive treatment of data analysis in Part IV. Part V deals with practical applications of the technique in the field of neuroscience and in clinical practice. The final section describes how fMRI can be integrated with other neuro-electromagnetic functional mapping techniques.
Inkster B, Rao AW, Ridler K, et al., 2012, Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease, NEUROBIOLOGY OF AGING, Vol: 33, Pages: 457-465, ISSN: 0197-4580
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