Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair, Head of Department
 
 
 
//

Contact

 

+44 (0)20 7594 2855p.matthews

 
 
//

Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
//

Location

 

E502Burlington DanesHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

612 results found

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Impaired myocardial perfusion in rheumatoid arthritis is associated with impaired strain, strain rate, disease activity and myocardial oedema: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Ntusi NA, Sever E, Lockey J, Francis JM, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2015, Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: A cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Ntusi NA, Holloway C, Francis JM, Davis A, Levelt E, Piechnik SK, Ferreira VM, Matthews PM, Wordsworth PB, Karamitsos TD, Neubauer Set al., 2015, Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: A phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647

Journal article

Jacobs HIL, Wiese S, van de Ven V, Gronenschild EHBM, Verhey FRJ, Matthews PMet al., 2015, Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia, NEUROBIOLOGY OF AGING, Vol: 36, Pages: 618-626, ISSN: 0197-4580

Journal article

Shields GS, Coissi GS, Jimenez-Royo P, Gambarota G, Dimber R, Hopkinson NS, Matthews PM, Brown AP, Polkey MIet al., 2015, BIOENERGETICS AND INTERMUSCULAR FAT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE-ASSOCIATED QUADRICEPS WEAKNESS, MUSCLE & NERVE, Vol: 51, Pages: 214-221, ISSN: 0148-639X

Journal article

Yang X, Nie L, Matthews PM, Tomassini V, Xu Z, Guo Yet al., 2015, The critical regularization value: incorporating spatial smoothness to enhance signal detection in highly noisy fMRI data, 7th Annual International IEEE EMBS Conference on Neural Engineering (NER), Publisher: IEEE, Pages: 1076-1079, ISSN: 1948-3546

Conference paper

Matthews PM, 2015, Professor Paul Matthews talks 'big data' within multiple sclerosis., Neurodegener Dis Manag, Vol: 5, Pages: 101-104

Journal article

Douaud G, Groves AR, Tamnes CK, Westlye LT, Duff EP, Engvig A, Walhovd KB, James A, Gass A, Monsch AU, Matthews PM, Fjell AM, Smith SM, Johansen-Berg Het al., 2014, A common brain network links development, aging, and vulnerability to disease, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 17648-17653, ISSN: 0027-8424

Journal article

Bishop CA, Ricotti V, Sinclair CDJ, Butler J, Evans RBM, Morrow JM, Hanna MG, Matthews PM, Yousry TA, Thornton JS, Muntoni F, Janiczek RLet al., 2014, Semi-automated analysis of diaphragmatic motion during deep breathing using dynamic MRI in both healthy controls and non-ambulant Duchenne muscular dystrophy, 19th International Congress of the World-Muscle-Society, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 852-853, ISSN: 0960-8966

Conference paper

Linortner P, Jehna M, Johansen-Berg H, Matthews PM, Schmidt R, Fazekas F, Enzinger Cet al., 2014, Aging associated changes in the motor control of ankle movements in the brain, NEUROBIOLOGY OF AGING, Vol: 35, Pages: 2222-2229, ISSN: 0197-4580

Journal article

Ntusi NAB, Sever E, Lockey J, Francis JM, Matthews PM, Wordsworth BP, Neubauer S, Karamitsos TDet al., 2014, Myocardial perfusion reserve is associated with impaired strain and higher disease activity in rheumatoid arthritis: cardiovascular magnetic resonance study, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 796-796, ISSN: 0195-668X

Conference paper

Colasanti A, Guo Q, Muhlert N, Giannetti P, Onega M, Newbould RD, Ciccarelli O, Rison S, Thomas C, Nicholas R, Muraro PA, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner EA, Matthews PMet al., 2014, In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with F-18-PBR111 PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 1112-1118, ISSN: 0161-5505

Journal article

Owen DR, Guo Q, Kalk NJ, Colasanti A, Kalogiannopoulou D, Dimber R, Lewis YL, Libri V, Barletta J, Ramada-Magalhaes J, Kamalakaran A, Nutt DJ, Passchier J, Matthews PM, Gunn RN, Rabiner EAet al., 2014, Determination of [C-11]PBR28 binding potential in vivo: a first human TSPO blocking study (vol 34, pg 1256, 2014), JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 34, Pages: 1256-1256, ISSN: 0271-678X

Journal article

Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DOet al., 2014, DEVELOPMENT OF WHOLE BODY AND INTRAVASCULAR NEAR-INFRARED OPTICAL MOLECULAR IMAGING OF MARKERS OF PLAQUE VULNERABLITY IN ATHEROSCLEROSIS, Annual Conference of the British-Cardiovascular-Society

Poster

Battaglini M, Rossi F, Grove RA, Stromillo ML, Whitcher B, Matthews PM, De Stefano Net al., 2014, Automated Identification of Brain New Lesions in Multiple Sclerosis Using Subtraction Images, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 39, Pages: 1543-1549, ISSN: 1053-1807

Journal article

Russo E, Khan S, Brown AP, Keat N, Hallett W, Janisch R, Gunn RN, Rabiner EA, Matthews PM, Orchard TRet al., 2014, CORRELATION OF FDG PET SCANNING WITH ENDOSCOPIC FINDINGS IN PATIENTS WITH CROHN'S DISEASE, GUT, Vol: 63, Pages: A74-A74, ISSN: 0017-5749

Journal article

Colasanti A, Guo Q, Giannetti P, Onega M, Owen DR, Piccini P, Gunn RN, Matthews PM, Rabiner EAet al., 2014, TSPO-targeted PET Imaging Suggests Increased Microglia Activation in Multiple Sclerosis Hippocampus is Correlated to Depressive Symptomatology, 69th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry, Publisher: ELSEVIER SCIENCE INC, Pages: 94S-95S, ISSN: 0006-3223

Conference paper

Matthews PM, 2014, An engaging tour through Oxford's medical history, LANCET, Vol: 383, Pages: 1201-1202, ISSN: 0140-6736

Journal article

Matthews PM, 2014, The virtues of adaptability, MULTIPLE SCLEROSIS JOURNAL, Vol: 20, Pages: 394-396, ISSN: 1352-4585

Journal article

Khamis R, Woollard K, Hyde G, Hara T, Mauskapf A, Granger D, Johnson J, Ntziachristos V, Matthews PM, Jaffer F, Haskard Det al., 2014, NEAR-INFRARED FLUORESCENCE (NIRF) WHOLE BODY AND INTRA-ARTERIAL MOLECULAR IMAGING OF OXIDIZED LDL IN EXPERIMENTAL ATHEROSCLEROSIS, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A2150-A2150, ISSN: 0735-1097

Journal article

Newbould RD, Nicholas R, Thomas CL, Quest R, Lee JSZ, Honeyfield L, Colasanti A, Malik O, Mattoscio M, Matthews PM, Sormani MP, Waldman AD, Muraroc PAet al., 2014, Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis, NeuroImage: Clinical, Vol: 4, Pages: 641-648, ISSN: 2213-1582

BackgroundMultiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration.ObjectiveTo determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI.Materials and methodsForty MS patients were recruited from out-patient clinics into two groups stratified by age but with similar clinical disease duration as well as thirteen controls age-matched to the older MS group. Images were segmented by automated programs and blinded readers into normal appearing white matter (NAWM), normal appearing gray matter (NAGM), and white matter lesions (WMLs) and gray matter lesions (GMLs) in the MS groups. WML and GML were delineated on T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) and T1 weighted MRI volumes. Mean magnetization transfer ratio (MTR), region volume, as well as MTR histogram skew and kurtosis were calculated for each region.ResultsAll MTR measures in NAGM and MTR histogram metrics in NAWM differed between MS subjects and controls, as expected and previously reported by several studies, but not between MS groups. However, MTR measures in the WML did significantly differ between the MS groups, in spite of no significant differences in lesion counts and volumes.ConclusionsDespite matching for clinical disease duration and recording no significant WML volume difference, we demonstrated strong MTR differences in WMLs between younger and older MS patients. These data suggest that aging-related processes modify the tissue response to inflammatory injury and its clinical outcome correlates in MS.

Journal article

Ntusi NAB, Piechnik SK, Francis JM, Ferreira VM, Rai ABS, Matthews PM, Robson MD, Moon J, Wordsworth PB, Neubauer S, Karamitsos TDet al., 2014, Subclinical myocardial inflammation and diffuse fibrosis are common in systemic sclerosis - a clinical study using myocardial T1-mapping and extracellular volume quantification, Journal of Cardiovascular Magnetic Resonance, Vol: 16, ISSN: 1097-6647

Background:Systemic sclerosis (SSc) is characterised by multi-organ tissue fibrosis including the myocardium. Diffuse myocardial fibrosis can be detected non-invasively by T1 and extracellular volume (ECV) quantification, while focal myocardial inflammation and fibrosis may be detected by T2-weighted and late gadolinium enhancement (LGE), respectively, using cardiovascular magnetic resonance (CMR). We hypothesised that multiparametric CMR can detect subclinical myocardial involvement in patients with SSc.Methods:19 SSc patients (18 female, mean age 55 ± 10 years) and 20 controls (19 female, mean age 56 ± 8 years) without overt cardiovascular disease underwent CMR at 1.5T, including cine, tagging, T1-mapping, T2-weighted, LGE imaging and ECV quantification.Results:Focal fibrosis on LGE was found in 10 SSc patients (53%) but none of controls. SSc patients also had areas of myocardial oedema on T2-weighted imaging (median 13 vs. 0% in controls). SSc patients had significantly higher native myocardial T1 values (1007 ± 29 vs. 958 ± 20 ms, p < 0.001), larger areas of myocardial involvement by native T1 >990 ms (median 52 vs. 3% in controls) and expansion of ECV (35.4 ± 4.8 vs. 27.6 ± 2.5%, p < 0.001), likely representing a combination of low-grade inflammation and diffuse myocardial fibrosis. Regardless of any regional fibrosis, native T1 and ECV were significantly elevated in SSc and correlated with disease activity and severity. Although biventricular size and global function were preserved, there was impairment in the peak systolic circumferential strain (-16.8 ± 1.6 vs. -18.6 ± 1.0, p < 0.001) and peak diastolic strain rate (83 ± 26 vs. 114 ± 16 s-1, p < 0.001) in SSc, which inversely correlated with diffuse myocardial fibrosis indices.Conclusions:Cardiac involvement is common in SSc even in the absence of cardiac symptoms, and includes chronic myocardial inflammation as well as foca

Journal article

Matthews PM, Geraghty OC, 2014, Understanding the pharmacology of stroke and multiple sclerosis through imaging, CURRENT OPINION IN PHARMACOLOGY, Vol: 14, Pages: 34-41, ISSN: 1471-4892

Journal article

Tawakol A, Singh P, Rudd JHF, Soffer J, Cai G, Vucic E, Brannan SP, Tarka EA, Shaddinger BC, Sarov-Blat L, Matthews P, Subramanian S, Farkouh M, Fayad ZAet al., 2014, Effect of Treatment for 12 Weeks With Rilapladib, a Lipoprotein-Associated Phospholipase A(2) Inhibitor, on Arterial Inflammation as Assessed With F-18-Fluorodeoxyglucose-Positron Emission Tomography Imaging, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: 86-88, ISSN: 0735-1097

Journal article

Matthews PM, Edison P, Geraghty OC, Johnson MRet al., 2014, The emerging agenda of stratified medicine in neurology, NATURE REVIEWS NEUROLOGY, Vol: 10, Pages: 15-26, ISSN: 1759-4758

Journal article

Harvey NC, Matthews P, Collins R, Cooper Cet al., 2013, Osteoporosis epidemiology in UK Biobank: a unique opportunity for international researchers, OSTEOPOROSIS INTERNATIONAL, Vol: 24, Pages: 2903-2905, ISSN: 0937-941X

Journal article

Zarei M, Beckmann CF, Binnewijzend MAA, Schoonheim MM, Oghabian MA, Sanz-Arigita EJ, Scheltens P, Matthews PM, Barkhof Fet al., 2013, Functional segmentation of the hippocampus in the healthy human brain and in Alzheimer's disease (vol 66, pg 28, 2013), NEUROIMAGE, Vol: 83, Pages: 1109-1109, ISSN: 1053-8119

Journal article

Colasanti A, Owen DR, Grozeva D, Rabiner EA, Matthews PM, Craddock N, Young AHet al., 2013, Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO), PSYCHONEUROENDOCRINOLOGY, Vol: 38, Pages: 2826-2829, ISSN: 0306-4530

Journal article

Wu C, Zhu J, Baeslack J, Zaremba A, Hecker J, Kraso J, Matthews PM, Miller RH, Wang Yet al., 2013, Longitudinal Positron Emission Tomography Imaging for Monitoring Myelin Repair in the Spinal Cord, ANNALS OF NEUROLOGY, Vol: 74, Pages: 688-698, ISSN: 0364-5134

Journal article

Colasanti A, Guo Q, Mulhert N, Giannetti P, Onega M, Ciccarelli O, Nicholas R, Muraro P, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner ER, Matthews PMet al., 2013, [18F]PBR111 binding in lesional and peri-lesional multiple sclerosis white matter, 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: 68-69, ISSN: 1352-4585

Conference paper

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00501273&limit=30&person=true&page=5&respub-action=search.html