Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

577 results found

, 2012, Functional magnetic resonance imaging: An introduction to methods, ISBN: 9780191724770

© Oxford University Press 2001. All rights reserved. This book provides an introduction to functional magnetic resonance imaging (fMRI), the scanning technique that allows the mapping of active processes within the brain. There are six sections to the book, with chapters from an international team. Part I provides a broad overview of the field and sets the context. Part II describes the physiological and physical background to fMRI, including coverage of the hardware required and pulse-sequence selection. Practical issues involving experimental design of the paradigms, psycho-physical stimulus delivery, and subject response are covered in Part III, followed by a comprehensive treatment of data analysis in Part IV. Part V deals with practical applications of the technique in the field of neuroscience and in clinical practice. The final section describes how fMRI can be integrated with other neuro-electromagnetic functional mapping techniques.

BOOK

Inkster B, Rao AW, Ridler K, Filippini N, Whitcher B, Nichols TE, Wetten S, Gibson RA, Borrie M, Kertesz A, Guzman DA, Loy-English I, Williams J, Saemann PG, Auer DP, Holsboer F, Tozzi F, Muglia P, Merlo-Pich E, Matthews PMet al., 2012, Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease, NEUROBIOLOGY OF AGING, Vol: 33, Pages: 457-465, ISSN: 0197-4580

JOURNAL ARTICLE

Filippini N, Nickerson LD, Beckmann CF, Ebmeier KP, Frisoni GB, Matthews PM, Smith SM, Mackay CEet al., 2012, Age-related adaptations of brain function during a memory task are also present at rest, NEUROIMAGE, Vol: 59, Pages: 3821-3828, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, Rabiner EA, Passchier J, Gunn RNet al., 2012, Positron emission tomography molecular imaging for drug development, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 73, Pages: 175-186, ISSN: 0306-5251

JOURNAL ARTICLE

De Silva A, Salem V, Matthews PM, Dhillo WSet al., 2012, The Use of Functional MRI to Study Appetite Control in the CNS, EXPERIMENTAL DIABETES RESEARCH, ISSN: 1687-5214

JOURNAL ARTICLE

Stagg CJ, Bachtiar V, O'Shea J, Allman C, Bosnell RA, Kischka U, Matthews PM, Johansen-Berg Het al., 2012, Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke, BRAIN, Vol: 135, Pages: 276-284, ISSN: 0006-8950

JOURNAL ARTICLE

Newbould RD, Miller SR, Tielbeek JAW, Toms LD, Rao AW, Gold GE, Strachan RK, Taylor PC, Matthews PM, Brown APet al., 2012, Reproducibility of sodium MRI measures of articular cartilage of the knee in osteoarthritis, OSTEOARTHRITIS AND CARTILAGE, Vol: 20, Pages: 29-35, ISSN: 1063-4584

JOURNAL ARTICLE

, 2012, Methods of measuring lung water, Journal of the Intensive Care Society, Vol: 13, Pages: 209-215, ISSN: 1751-1437

Pulmonary oedema can result from both cardiogenic and non-cardiogenic aetiologies and is a cause of considerable morbidity and mortality. Accurate methods of quantifying pulmonary oedema are needed for both clinical and research purposes. Applications could include early recognition, and thus prevention, of impending decompensation in heart failure patients, guidance of fluid management in patients with established pulmonary oedema, and as a pharmacodynamic outcome measure for early clinical trials of drugs for the treatment of pulmonary oedema. Magnetic resonance imaging, computed tomography, positron emission tomography, electrical impedance, and thermodilution methods have all been used with the aim of measuring lung water. These methods differ in their accuracy, cost, ionising radiation dose, invasiveness, portability, and ability to provide dynamic measures. To date, none have been established as a 'gold standard' clinical measurement to improve clinical outcomes or to assist drug development. This review aims to discuss each of these methods in turn, focussing on advantages, limitations, and possible future development and applications. © The Intensive Care Society 2012.

JOURNAL ARTICLE

Salem V, De Silva A, Matthews PM, Dhillo WSet al., 2012, Imaging the neuroendocrinology of appetite., Adipocyte, Vol: 1, Pages: 68-72, ISSN: 2162-3945

Functional magnetic resonance imaging has become a powerful tool to investigate the neuroendocrinology of appetite. In a recent study, we demonstrated that the brain activation pattern seen following the infusion of the anorectic gut hormones PYY3-36 and GLP-17-36 amide to fasted individuals resembles the brain activation pattern seen in the physiological satiated state. This commentary discusses the significance of these findings and compares them with other landmark studies in the field, with specific reference to the brain areas involved in appetite regulation. We highlight the importance of this type of research in order to pave the way for the development of efficacious and safe anti-obesity therapies.

JOURNAL ARTICLE

Owen DR, Yeo AJ, Gunn RN, Song K, Wadsworth G, Lewis A, Rhodes C, Pulford DJ, Bennacef I, Parker CA, StJean PL, Cardon LR, Mooser VE, Matthews PM, Rabiner EA, Rubio JPet al., 2012, An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 32, Pages: 1-5, ISSN: 0271-678X

JOURNAL ARTICLE

Zarei M, Mataix-Cols D, Heyman I, Hough M, Doherty J, Burge L, Winmill L, Nijhawan S, Matthews PM, James Aet al., 2011, Changes in Gray Matter Volume and White Matter Microstructure in Adolescents with Obsessive-Compulsive Disorder, BIOLOGICAL PSYCHIATRY, Vol: 70, Pages: 1083-1090, ISSN: 0006-3223

JOURNAL ARTICLE

Patsopoulos NA, de Bakker PIW, 2011, Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci, ANNALS OF NEUROLOGY, Vol: 70, Pages: 897-912, ISSN: 0364-5134

JOURNAL ARTICLE

, 2011, Axonal pathology in patients with multiple sclerosis: Evidence from in vivo proton magnetic resonance spectroscopy, Multiple Sclerosis Therapeutics, Fourth Edition, Pages: 150-164, ISBN: 9781139023986

© Cambridge University Press 2011. Introduction The clinical course of multiple sclerosis (MS) is highly variable, and pathological changes that are seen with the disease are heterogeneous amongst individuals. In recent years, there has been increasing interest in the development of magnetic resonance imaging (MRI) approaches to characterizing the pathological substrates of disability in MS with the objective of developing quantitative in vivo indices of pathology that could provide new insights into the pathogenesis of the disease, as well as provide more specific or sensitive end-points for treatment trials. This chapter reviews results from studies that have used either proton magnetic resonance spectroscopy (1H-MRS, a technique that allows for the acquisition of 1H-MR spectra from single voxels) or 1H-MR spectroscopic imaging (1H-MRSI, a technique that allows for the simultaneous acquisition of 1H-MR spectra from multiple voxels) to measure in vivo chemical pathology associated with impairment of axonal metabolic or structural integrity, and places these results in the context of relevant histopathological investigations. We will focus on an important hypothesis that has developed from these studies: that axonal pathology is central to the final common pathway leading to the progressive disability that is seen in individuals with this disease.

BOOK CHAPTER

Mistry P, Dixon IJ, Hallett WA, Whitcher B, Brown AP, Zvartau-Hind M, Lotay N, Lai RYK, Castiglia M, Jeter B, Matthews JC, Chen K, Bandy D, Reiman EM, Gold M, Rabiner EA, Matthews PMet al., 2011, Validation and pilot application of [ <sup>18</sup>F]FDG-PET in evaluation of a metabolic therapy for Alzheimer's disease, Advances in Alzheimer's Disease, Vol: 2, Pages: 627-642, ISSN: 2210-5727

Here we describe methods for application of quantitative fluorodeoxyglucose positron emission tomography ([ 18F]FDG-PET) measures of brain glucose metabolism in multi-centre clinical trials for Alzheimer's disease. We validated methods and demonstrated their use in the context of a treatment trial with the PPARγ agonist Rosiglitazone XR versus placebo in mild to moderate AD patients. Novel quantitative indices related to the combined forward rate constant for [ 18F]FDG uptake \(({K}-{i}^{index})\) and to the rate of cerebral glucose utilization \((CM{R}-{glu}^{index})\) were applied. Active treatment was associated with a sustained but not statistically significant trend from the first month for higher mean values in both. However, neither these nor another analytical approach recently validated using data from the Alzheimer's Disease Neuroimaging Initiative suggested that active treatment decreased the progression of decline in brain glucose metabolism. Rates of brain atrophy were similar between active and placebo groups and measures of cognition also did not demonstrate clear group differences. Our study demonstrates the feasibility of using [ 18F]FDG-PET as part of a multi-centre therapeutics trial and describes new measures that can be employed. It suggests that Rosiglitazone is associated with an early increase in whole brain glucose utilisation, but not with any biological or clinical evidence for slowing progression over the period of study in the selected patient group. © 2011 The authors and IOS Press. All rights reserved.

JOURNAL ARTICLE

De Silva A, Salem V, Long CJ, Makwana A, Newbould RD, Rabiner EA, Ghatei MA, Bloom SR, Matthews PM, Beaver JD, Dhillo WSet al., 2011, The Gut Hormones PYY3-36 and GLP-1(7-36) amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans, CELL METABOLISM, Vol: 14, Pages: 700-706, ISSN: 1550-4131

JOURNAL ARTICLE

Thomas EL, Makwana A, Newbould R, Rao AW, Gambarota G, Frost G, Delafont B, Mishra RG, Matthews PM, Berk ES, Schwartz SM, Bell JD, Beaver JDet al., 2011, Pragmatic study of orlistat 60mg on abdominal obesity, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 1256-1262, ISSN: 0954-3007

JOURNAL ARTICLE

Strijbis EMM, Inkster B, Vounou M, Kappos L, Radu E-W, Matthews PM, Uitdehaag B, Barkhof F, Geurts JJGet al., 2011, The explanatory value of glutamatergic SNPs on combined MRI phenotypes in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S114-S115, ISSN: 1352-4585

JOURNAL ARTICLE

Inkster B, Rao AW, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Tozzi F, Muglia P, Merlo-Pich E, Matthews PMet al., 2011, Structural Brain Changes in Patients with Recurrent Major Depressive Disorder Presenting with Anxiety Symptoms, JOURNAL OF NEUROIMAGING, Vol: 21, Pages: 375-382, ISSN: 1051-2284

JOURNAL ARTICLE

Inkster B, Strijbis EMM, Vounou M, Kappos L, Radue EW, Matthews PM, Uitdehaag B, Barkhof F, Polman CH, Montana G, Geurts JJGet al., 2011, Mitochondrial sirtuin gene variants and brain volume changes in patients with multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S333-S334, ISSN: 1352-4585

JOURNAL ARTICLE

Matthews PM, Rabiner I, Gunn R, 2011, Non-invasive imaging in experimental medicine for drug development, CURRENT OPINION IN PHARMACOLOGY, Vol: 11, Pages: 501-507, ISSN: 1471-4892

JOURNAL ARTICLE

Roosendaal SD, Bendfeldt K, Vrenken H, Polman CH, Borgwardt S, Radue EW, Kappos L, Pelletier D, Hauser SL, Matthews PM, Barkhof F, Geurts JJGet al., 2011, Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 1098-1106, ISSN: 1352-4585

JOURNAL ARTICLE

Bosnell RA, Kincses T, Stagg CJ, Tomassini V, Kischka U, Jbabdi S, Woolrich MW, Andersson J, Matthews PM, Johansen-Berg Het al., 2011, Motor Practice Promotes Increased Activity in Brain Regions Structurally Disconnected After Subcortical Stroke, NEUROREHABILITATION AND NEURAL REPAIR, Vol: 25, Pages: 607-616, ISSN: 1545-9683

JOURNAL ARTICLE

Rabiner EA, Beaver J, Makwana A, Searle G, Long C, Nathan PJ, Newbould RD, Howard J, Miller SR, Bush MA, Hill S, Reiley R, Passchier J, Gunn RN, Matthews PM, Bullmore ETet al., 2011, Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans, MOLECULAR PSYCHIATRY, Vol: 16, Pages: 826-835, ISSN: 1359-4184

JOURNAL ARTICLE

Colasanti A, Searle GE, Long CJ, Hill SP, Reiley RR, Tziortzi AC, Quelch D, Gunn R, Waldman AD, Schruers KJ, Matthews PM, Nutt DJ, Rabiner EAet al., 2011, OPIOID RELEASE IN HUMAN BRAIN REWARD SYSTEM INDUCED BY AN ACUTE AMPHETAMINE CHALLENGE: A [11C]CARFENTANIL PET STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A60-A60, ISSN: 0269-8811

CONFERENCE PAPER

Beaver JD, Long CJ, Cole DM, Durcan MJ, Bannon LC, Mishra RG, Matthews PMet al., 2011, The Effects of Nicotine Replacement on Cognitive Brain Activity During Smoking Withdrawal Studied with Simultaneous fMRI/EEG, NEUROPSYCHOPHARMACOLOGY, Vol: 36, Pages: 1792-1800, ISSN: 0893-133X

JOURNAL ARTICLE

Rabiner EA, Beaver J, Makwana A, Searle G, Long C, Nathan PJ, Newbould RD, Howard J, Miller SR, Bush MA, Hill S, Reiley R, Passchier J, Gunn RN, Matthews PM, Bullmore ETet al., 2011, Molecular and functional neuroimaging of human opioid receptor pharmacology., Mol Psychiatry, Vol: 16

JOURNAL ARTICLE

Dixson L, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM, Inkster Bet al., 2011, Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls, PSYCHONEUROENDOCRINOLOGY, Vol: 36, Pages: 929-934, ISSN: 0306-4530

JOURNAL ARTICLE

Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MDet al., 2011, A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility, GENES AND IMMUNITY, Vol: 12, Pages: 335-340, ISSN: 1466-4879

JOURNAL ARTICLE

James A, Hough M, James S, Winmill L, Burge L, Nijhawan S, Matthews PM, Zarei Met al., 2011, Greater white and grey matter changes associated with early cannabis use in adolescent-onset schizophrenia (AOS), SCHIZOPHRENIA RESEARCH, Vol: 128, Pages: 91-97, ISSN: 0920-9964

JOURNAL ARTICLE

Sombekke MH, Jafari N, Bendfeldt K, Mueller-Lenke N, Radue EW, Naegelin Y, Kappos L, Matthews PM, Polman CH, Barkhof F, Hintzen R, Geurts JJGet al., 2011, NO INFLUENCE OF KIF1B ON NEURODEGENERATIVE MARKERS IN MULTIPLE SCLEROSIS, NEUROLOGY, Vol: 76, Pages: 1843-1845, ISSN: 0028-3878

JOURNAL ARTICLE

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