Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

576 results found

Stagg CJ, Jayaram G, Pastor D, Kincses ZT, Matthews PM, Johansen-Berg Het al., 2011, Polarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning, NEUROPSYCHOLOGIA, Vol: 49, Pages: 800-804, ISSN: 0028-3932

JOURNAL ARTICLE

Strijbis EMM, Inkster B, Vounou M, Kappos L, Radu E-W, Matthews PM, Uitdehaag B, Barkhof F, Geurts JJGet al., 2011, The explanatory value of glutamatergic SNPs on combined MRI phenotypes in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S114-S115, ISSN: 1352-4585

JOURNAL ARTICLE

Thomas EL, Makwana A, Newbould R, Rao AW, Gambarota G, Frost G, Delafont B, Mishra RG, Matthews PM, Berk ES, Schwartz SM, Bell JD, Beaver JDet al., 2011, Pragmatic study of orlistat 60mg on abdominal obesity, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 1256-1262, ISSN: 0954-3007

JOURNAL ARTICLE

Tomassini V, Jbabdi S, Kincses ZT, Bosnell R, Douaud G, Pozzilli C, Matthews PM, Johansen-Berg Het al., 2011, Structural and Functional Bases for Individual Differences in Motor Learning, HUMAN BRAIN MAPPING, Vol: 32, Pages: 494-508, ISSN: 1065-9471

JOURNAL ARTICLE

Tomassini V, Johansen-Berg H, Leonardi L, Paixao L, Jbabdi S, Palace J, Pozzilli C, Matthews PMet al., 2011, Preservation of motor skill learning in patients with multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 103-115, ISSN: 1352-4585

JOURNAL ARTICLE

Tzimopoulou S, Cunningham VJ, Nichols TE, Searle G, Bird NP, Mistry P, Dixon IJ, Hallett WA, Whitcher B, Brown AP, Zvartau-Hind M, Lotay N, Lai RYK, Castiglia M, Jeter B, Matthews JC, Chen K, Bandy D, Reiman EM, Gold M, Rabiner EA, Matthews PMet al., 2011, Validation and pilot application of [ <sup>18</sup>F]FDG-PET in evaluation of a metabolic therapy for Alzheimer's disease, Advances in Alzheimer's Disease, Vol: 2, Pages: 627-642, ISSN: 2210-5727

Here we describe methods for application of quantitative fluorodeoxyglucose positron emission tomography ([ 18F]FDG-PET) measures of brain glucose metabolism in multi-centre clinical trials for Alzheimer's disease. We validated methods and demonstrated their use in the context of a treatment trial with the PPARγ agonist Rosiglitazone XR versus placebo in mild to moderate AD patients. Novel quantitative indices related to the combined forward rate constant for [ 18F]FDG uptake \(({K}-{i}^{index})\) and to the rate of cerebral glucose utilization \((CM{R}-{glu}^{index})\) were applied. Active treatment was associated with a sustained but not statistically significant trend from the first month for higher mean values in both. However, neither these nor another analytical approach recently validated using data from the Alzheimer's Disease Neuroimaging Initiative suggested that active treatment decreased the progression of decline in brain glucose metabolism. Rates of brain atrophy were similar between active and placebo groups and measures of cognition also did not demonstrate clear group differences. Our study demonstrates the feasibility of using [ 18F]FDG-PET as part of a multi-centre therapeutics trial and describes new measures that can be employed. It suggests that Rosiglitazone is associated with an early increase in whole brain glucose utilisation, but not with any biological or clinical evidence for slowing progression over the period of study in the selected patient group. © 2011 The authors and IOS Press. All rights reserved.

JOURNAL ARTICLE

Valsasina P, Rocca MA, Absinta M, Sormani MP, Mancini L, De Stefano N, Rovira A, Gass A, Enzinger C, Barkhof F, Wegner C, Matthews PM, Filippi Met al., 2011, A multicentre study of motor functional connectivity changes in patients with multiple sclerosis, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 1256-1263, ISSN: 0953-816X

JOURNAL ARTICLE

Wahjoepramono EJ, Wijaya LK, Taddei K, Bates KA, Howard M, Martins G, deRuyck K, Matthews PM, Verdile G, Martins RNet al., 2011, Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels, NEUROENDOCRINOLOGY, Vol: 94, Pages: 313-322, ISSN: 0028-3835

JOURNAL ARTICLE

Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PIW, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JRet al., 2011, Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data, GENOME MEDICINE, Vol: 3, ISSN: 1756-994X

JOURNAL ARTICLE

Zarei M, Mataix-Cols D, Heyman I, Hough M, Doherty J, Burge L, Winmill L, Nijhawan S, Matthews PM, James Aet al., 2011, Changes in Gray Matter Volume and White Matter Microstructure in Adolescents with Obsessive-Compulsive Disorder, BIOLOGICAL PSYCHIATRY, Vol: 70, Pages: 1083-1090, ISSN: 0006-3223

JOURNAL ARTICLE

Antoniades A, Matthews PM, Pattichis CS, Galwey NWet al., 2010, A Computationally Fast Measure Of Epistasis For 2 SNPs And A Categorical Phenotype, 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Pages: 6194-6197, ISSN: 1557-170X

JOURNAL ARTICLE

Antoniades A, Matthews PM, Pattichis CS, Galwey NWet al., 2010, A computationally fast measure of epistasis for 2 SNPs and a categorical phenotype, Pages: 6194-6197

Complex diseases may be caused by interactions or combined effects between multiple genetic and environmental factors. One of the main limitations of testing for interaction between genetic loci in large whole genome studies is the high computational cost of performing such analyses. In this study a new methodology for interaction testing (commonly referred to in genetics as the epistatic effect) between two single nucleotide polymorphisms (SNPs) and a categorical phenotype is presented. It is shown that it provides reasonable approximations with a significantly shorter run time. The proposed measure based on the Pearson's chi-square additive property is compared to fitting a logistic regression model on a randomly selected subset of 218 SNP loci from a study that included 550,000 SNPs). For each possible pair of SNPs a chi-square test for the epistatic effect on case-control status is estimated by fitting a logistic regression model, and compared to the results of the proposed method. Results indicate strong agreement (Pearson's correlation r>0.95) while the proposed method is found to be 20 times faster. This provides a significant pragmatic advantage for the proposed method since the number of tests for epistasis can now be increased by a factor of 20 while the computational cost remains the same. © 2010 IEEE.

CONFERENCE PAPER

Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier Det al., 2010, Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis, BRAIN, Vol: 133, Pages: 2603-2611, ISSN: 0006-8950

JOURNAL ARTICLE

Cole DM, Beckmann CF, Long CJ, Matthews PM, Durcan MJ, Beaver JDet al., 2010, Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics, NEUROIMAGE, Vol: 52, Pages: 590-599, ISSN: 1053-8119

JOURNAL ARTICLE

Giorgio A, Watkins KE, Chadwick M, James S, Winmill L, Douaud G, De Stefano N, Matthews PM, Smith SM, Johansen-Berg H, James ACet al., 2010, Longitudinal changes in grey and white matter during adolescence, NEUROIMAGE, Vol: 49, Pages: 94-103, ISSN: 1053-8119

JOURNAL ARTICLE

Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, Depondt C, Need AC, Walley NM, Nicoletti P, Ge D, Catarino CB, Duncan JS, Kasperaviciute D, Tate SK, Caboclo LO, Sander JW, Clayton L, Linney KN, Shianna KV, Gumbs CE, Smith J, Cronin KD, Maia JM, Doherty CP, Pandolfo M, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Kalviainen R, Eriksson K, Kantanen A-M, Dorn T, Hansen J, Kraemer G, Steinhoff BJ, Wieser H-G, Zumsteg D, Ortega M, Wood NW, Huxley-Jones J, Mikati M, Gallentine WB, Husain AM, Buckley PG, Stallings RL, Podgoreanu MV, Delanty N, Sisodiya SM, Goldstein DBet al., 2010, Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 86, Pages: 707-718, ISSN: 0002-9297

JOURNAL ARTICLE

Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PMet al., 2010, Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression, NEUROIMAGE, Vol: 53, Pages: 908-917, ISSN: 1053-8119

JOURNAL ARTICLE

Kasperaviciute D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LMS, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser H-G, Steinhoff BJ, Kraermer G, Hansen J, Dorn T, Kantanen A-M, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kalviainen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SMet al., 2010, Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study, BRAIN, Vol: 133, Pages: 2136-2147, ISSN: 0006-8950

JOURNAL ARTICLE

Matthews PM, 2010, IMAGING FOR TRANSLATIONAL PHARMACOLOGY, IRISH JOURNAL OF MEDICAL SCIENCE, Vol: 179, Pages: S99-S100, ISSN: 0021-1265

JOURNAL ARTICLE

Menke RA, Jbabdi S, Miller KL, Matthews PM, Zarei Met al., 2010, Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease, NEUROIMAGE, Vol: 52, Pages: 1175-1180, ISSN: 1053-8119

JOURNAL ARTICLE

Menke RA, Jbabdi S, Miller KL, Matthews PM, Zarei Met al., 2010, Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease., Neuroimage, Vol: 52, Pages: 1175-1180

The aims of this study were to i) identify substantia nigra subregions i.e. pars reticulata (SNr) and pars compacta (SNc), in human, and ii) to assess volumetric changes in these subregions in the diagnosis of Parkinson's disease. Current MR imaging techniques are unable to distinguish SNr and SNc. Segmentation of these regions may be clinically useful in Parkinson's disease (PD) as substantia nigra is invariably affected in PD. We acquired quantitative T1 as well as diffusion tensor imaging (DTI) data from ten healthy subjects and ten PD patients. For each subject, the left and right SN were manually outlined on T1 images and then classified into two discrete regions based on the characteristics of their connectivity with the rest of the brain using an automated clustering method on the DTI data. We identified two regions in each subjects' SN: an internal region that is likely to correspond with SNc because it was mainly connected with posterior striatum, pallidum, anterior thalamus, and prefrontal cortex; and an external region that corresponds with SNr because it was chiefly connected with posterior thalamus, ventral thalamus, and motor cortex. Volumetric study of these regions in PD patients showed a general atrophy in PD particularly in the right SNr. This pilot study showed that automated DTI-based parcellation of SN subregions may provide a useful tool for in-vivo identification of SNc and SNr and might therefore assist to detect changes that occur in patients with PD.

JOURNAL ARTICLE

Nalbantian S, Matthews PM, McClelland JL, 2010, The Memory Process, Publisher: Mit Pr, ISBN: 9780262014571

The convergence of neuroscience, philosophy, art, music, and literature offers valuablenew insights into the study of memory.

BOOK

Owen DR, Howell OW, Tang S-P, Wells LA, Bennacef I, Bergstrom M, Gunn RN, Rabiner EA, Wilkins MR, Reynolds R, Matthews PM, Parker CAet al., 2010, Two binding sites for [H-3]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 30, Pages: 1608-1618, ISSN: 0271-678X

JOURNAL ARTICLE

Owen DR, Rabiner EA, Gunn RN, Matthews PM, Parker CAet al., 2010, PBR28, PBR06 and PBR111 bind two distinct TSPO sites in human brain tissue, 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S30-S31, ISSN: 1053-8119

CONFERENCE PAPER

Pomeroy IM, Jordan EK, Frank JA, Matthews PM, Esiri MMet al., 2010, Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 16, Pages: 537-548, ISSN: 1352-4585

JOURNAL ARTICLE

Sloan HL, Austin VC, Blamire AM, Schnupp JWH, Lowe AS, Allers KA, Matthews PM, Sibson NRet al., 2010, Regional differences in neurovascular coupling in rat brain as determined by fMRI and electrophysiology, NEUROIMAGE, Vol: 53, Pages: 399-411, ISSN: 1053-8119

JOURNAL ARTICLE

Tzimopoulou S, Cunningham VJ, Nichols TE, Searle G, Bird NP, Mistry P, Dixon IJ, Hallett WA, Whitcher B, Brown AP, Zvartau-Hind M, Lotay N, Lai RYK, Castiglia M, Jeter B, Matthews JC, Chen K, Bandy D, Reiman EM, Gold M, Rabiner EA, Matthews PMet al., 2010, A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [F-18]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease, JOURNAL OF ALZHEIMERS DISEASE, Vol: 22, Pages: 1241-1256, ISSN: 1387-2877

JOURNAL ARTICLE

Wise RG, Pattinson KTS, Bulte DP, Rogers R, Tracey I, Matthews PM, Jezzard Pet al., 2010, Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia, MAGNETIC RESONANCE IMAGING, Vol: 28, Pages: 1129-1134, ISSN: 0730-725X

JOURNAL ARTICLE

Zarei M, Patenaude B, Damoiseaux J, Morgese C, Smith S, Matthews PM, Barkhof F, Rombouts S, Sanz-Arigita E, Jenkinson Met al., 2010, Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease, NEUROIMAGE, Vol: 49, Pages: 1-8, ISSN: 1053-8119

JOURNAL ARTICLE

Zarei M, Patenaude B, Damoiseaux J, Morgese C, Smith S, Matthews PM, Barkhof F, Rombouts SARB, Sanz-Arigita E, Jenkinson Met al., 2010, Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease (vol 49, pg 1, 2010), NEUROIMAGE, Vol: 51, Pages: 940-940, ISSN: 1053-8119

JOURNAL ARTICLE

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