Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
//

Contact

 

+44 (0)20 7594 2855p.matthews

 
 
//

Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
//

Location

 

E502Burlington DanesHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

582 results found

Rabiner EA, Beaver J, Makwana A, Searle G, Long C, Nathan PJ, Newbould RD, Howard J, Miller SR, Bush MA, Hill S, Reiley R, Passchier J, Gunn RN, Matthews PM, Bullmore ETet al., 2011, Molecular and functional neuroimaging of human opioid receptor pharmacology., Mol Psychiatry, Vol: 16

JOURNAL ARTICLE

Dixson L, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM, Inkster Bet al., 2011, Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls, PSYCHONEUROENDOCRINOLOGY, Vol: 36, Pages: 929-934, ISSN: 0306-4530

JOURNAL ARTICLE

Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MDet al., 2011, A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility, GENES AND IMMUNITY, Vol: 12, Pages: 335-340, ISSN: 1466-4879

JOURNAL ARTICLE

James A, Hough M, James S, Winmill L, Burge L, Nijhawan S, Matthews PM, Zarei Met al., 2011, Greater white and grey matter changes associated with early cannabis use in adolescent-onset schizophrenia (AOS), SCHIZOPHRENIA RESEARCH, Vol: 128, Pages: 91-97, ISSN: 0920-9964

JOURNAL ARTICLE

Sombekke MH, Jafari N, Bendfeldt K, Mueller-Lenke N, Radue EW, Naegelin Y, Kappos L, Matthews PM, Polman CH, Barkhof F, Hintzen R, Geurts JJGet al., 2011, NO INFLUENCE OF KIF1B ON NEURODEGENERATIVE MARKERS IN MULTIPLE SCLEROSIS, NEUROLOGY, Vol: 76, Pages: 1843-1845, ISSN: 0028-3878

JOURNAL ARTICLE

Stagg CJ, Jayaram G, Pastor D, Kincses ZT, Matthews PM, Johansen-Berg Het al., 2011, Polarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning, NEUROPSYCHOLOGIA, Vol: 49, Pages: 800-804, ISSN: 0028-3932

JOURNAL ARTICLE

Dennis A, Bosnell R, Dawes H, Howells K, Cockburn J, Kischka U, Matthews P, Johansen-Berg Het al., 2011, Cognitive Context Determines Dorsal Premotor Cortical Activity During Hand Movement in Patients After Stroke, STROKE, Vol: 42, Pages: 1056-1061, ISSN: 0039-2499

JOURNAL ARTICLE

Valsasina P, Rocca MA, Absinta M, Sormani MP, Mancini L, De Stefano N, Rovira A, Gass A, Enzinger C, Barkhof F, Wegner C, Matthews PM, Filippi Met al., 2011, A multicentre study of motor functional connectivity changes in patients with multiple sclerosis, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 1256-1263, ISSN: 0953-816X

JOURNAL ARTICLE

Douaud G, Jbabdi S, Behrens TEJ, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Kindlmann G, Matthews PM, Smith Set al., 2011, DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease, NEUROIMAGE, Vol: 55, Pages: 880-890, ISSN: 1053-8119

JOURNAL ARTICLE

Tomassini V, Jbabdi S, Kincses ZT, Bosnell R, Douaud G, Pozzilli C, Matthews PM, Johansen-Berg Het al., 2011, Structural and Functional Bases for Individual Differences in Motor Learning, HUMAN BRAIN MAPPING, Vol: 32, Pages: 494-508, ISSN: 1065-9471

JOURNAL ARTICLE

Owen DRJ, Piccini P, Matthews PM, 2011, Towards molecular imaging of multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 262-272, ISSN: 1352-4585

JOURNAL ARTICLE

James A, Hough M, James S, Burge L, Winmill L, Nijhawan S, Matthews PM, Zarei Met al., 2011, Structural brain and neuropsychometric changes associated with pediatric bipolar disorder with psychosis, BIPOLAR DISORDERS, Vol: 13, Pages: 16-27, ISSN: 1398-5647

JOURNAL ARTICLE

Wahjoepramono EJ, Wijaya LK, Taddei K, Bates KA, Howard M, Martins G, deRuyck K, Matthews PM, Verdile G, Martins RNet al., 2011, Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels, NEUROENDOCRINOLOGY, Vol: 94, Pages: 313-322, ISSN: 0028-3835

JOURNAL ARTICLE

Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PIW, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JRet al., 2011, Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data, GENOME MEDICINE, Vol: 3, ISSN: 1756-994X

JOURNAL ARTICLE

Owen DRJ, Matthews PM, 2011, IMAGING BRAIN MICROGLIAL ACTIVATION USING POSITRON EMISSION TOMOGRAPHY AND TRANSLOCATOR PROTEIN-SPECIFIC RADIOLIGANDS, BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE, Vol: 101, Pages: 19-39, ISSN: 0074-7742

JOURNAL ARTICLE

Owen DRJ, Gunn RN, Rabiner EA, Bennacef I, Fujita M, Kreisl WC, Innis RB, Pike VW, Reynolds R, Matthews PM, Parker CAet al., 2011, Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands, JOURNAL OF NUCLEAR MEDICINE, Vol: 52, Pages: 24-32, ISSN: 0161-5505

JOURNAL ARTICLE

Crofts JJ, Higham DJ, Bosnell R, Jbabdi S, Matthews PM, Behrens TEJ, Johansen-Berg Het al., 2011, Network analysis detects changes in the contralesional hemisphere following stroke, NEUROIMAGE, Vol: 54, Pages: 161-169, ISSN: 1053-8119

JOURNAL ARTICLE

Tomassini V, Johansen-Berg H, Leonardi L, Paixao L, Jbabdi S, Palace J, Pozzilli C, Matthews PMet al., 2011, Preservation of motor skill learning in patients with multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 103-115, ISSN: 1352-4585

JOURNAL ARTICLE

Filippini N, Ebmeier KP, MacIntosh BJ, Trachtenberg AJ, Frisoni GB, Wilcock GK, Beckmann CF, Smith SM, Matthews PM, Mackay CEet al., 2011, Differential effects of the APOE genotype on brain function across the lifespan, NEUROIMAGE, Vol: 54, Pages: 602-610, ISSN: 1053-8119

JOURNAL ARTICLE

Antoniades A, Matthews PM, Pattichis CS, Galwey NWet al., 2010, A computationally fast measure of epistasis for 2 SNPs and a categorical phenotype, Pages: 6194-6197

Complex diseases may be caused by interactions or combined effects between multiple genetic and environmental factors. One of the main limitations of testing for interaction between genetic loci in large whole genome studies is the high computational cost of performing such analyses. In this study a new methodology for interaction testing (commonly referred to in genetics as the epistatic effect) between two single nucleotide polymorphisms (SNPs) and a categorical phenotype is presented. It is shown that it provides reasonable approximations with a significantly shorter run time. The proposed measure based on the Pearson's chi-square additive property is compared to fitting a logistic regression model on a randomly selected subset of 218 SNP loci from a study that included 550,000 SNPs). For each possible pair of SNPs a chi-square test for the epistatic effect on case-control status is estimated by fitting a logistic regression model, and compared to the results of the proposed method. Results indicate strong agreement (Pearson's correlation r>0.95) while the proposed method is found to be 20 times faster. This provides a significant pragmatic advantage for the proposed method since the number of tests for epistasis can now be increased by a factor of 20 while the computational cost remains the same. © 2010 IEEE.

CONFERENCE PAPER

Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PMet al., 2010, Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression, NEUROIMAGE, Vol: 53, Pages: 908-917, ISSN: 1053-8119

JOURNAL ARTICLE

Sloan HL, Austin VC, Blamire AM, Schnupp JWH, Lowe AS, Allers KA, Matthews PM, Sibson NRet al., 2010, Regional differences in neurovascular coupling in rat brain as determined by fMRI and electrophysiology, NEUROIMAGE, Vol: 53, Pages: 399-411, ISSN: 1053-8119

JOURNAL ARTICLE

Wise RG, Pattinson KTS, Bulte DP, Rogers R, Tracey I, Matthews PM, Jezzard Pet al., 2010, Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia, MAGNETIC RESONANCE IMAGING, Vol: 28, Pages: 1129-1134, ISSN: 0730-725X

JOURNAL ARTICLE

Menke RA, Jbabdi S, Miller KL, Matthews PM, Zarei Met al., 2010, Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease, NEUROIMAGE, Vol: 52, Pages: 1175-1180, ISSN: 1053-8119

JOURNAL ARTICLE

Menke RA, Jbabdi S, Miller KL, Matthews PM, Zarei Met al., 2010, Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease., Neuroimage, Vol: 52, Pages: 1175-1180

The aims of this study were to i) identify substantia nigra subregions i.e. pars reticulata (SNr) and pars compacta (SNc), in human, and ii) to assess volumetric changes in these subregions in the diagnosis of Parkinson's disease. Current MR imaging techniques are unable to distinguish SNr and SNc. Segmentation of these regions may be clinically useful in Parkinson's disease (PD) as substantia nigra is invariably affected in PD. We acquired quantitative T1 as well as diffusion tensor imaging (DTI) data from ten healthy subjects and ten PD patients. For each subject, the left and right SN were manually outlined on T1 images and then classified into two discrete regions based on the characteristics of their connectivity with the rest of the brain using an automated clustering method on the DTI data. We identified two regions in each subjects' SN: an internal region that is likely to correspond with SNc because it was mainly connected with posterior striatum, pallidum, anterior thalamus, and prefrontal cortex; and an external region that corresponds with SNr because it was chiefly connected with posterior thalamus, ventral thalamus, and motor cortex. Volumetric study of these regions in PD patients showed a general atrophy in PD particularly in the right SNr. This pilot study showed that automated DTI-based parcellation of SN subregions may provide a useful tool for in-vivo identification of SNc and SNr and might therefore assist to detect changes that occur in patients with PD.

JOURNAL ARTICLE

Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier Det al., 2010, Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis, BRAIN, Vol: 133, Pages: 2603-2611, ISSN: 0006-8950

JOURNAL ARTICLE

Owen DR, Howell OW, Tang S-P, Wells LA, Bennacef I, Bergstrom M, Gunn RN, Rabiner EA, Wilkins MR, Reynolds R, Matthews PM, Parker CAet al., 2010, Two binding sites for [H-3]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 30, Pages: 1608-1618, ISSN: 0271-678X

JOURNAL ARTICLE

Cole DM, Beckmann CF, Long CJ, Matthews PM, Durcan MJ, Beaver JDet al., 2010, Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics, NEUROIMAGE, Vol: 52, Pages: 590-599, ISSN: 1053-8119

JOURNAL ARTICLE

Owen DR, Rabiner EA, Gunn RN, Matthews PM, Parker CAet al., 2010, PBR28, PBR06 and PBR111 bind two distinct TSPO sites in human brain tissue, 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S30-S31, ISSN: 1053-8119

CONFERENCE PAPER

Kasperaviciute D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LMS, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser H-G, Steinhoff BJ, Kraermer G, Hansen J, Dorn T, Kantanen A-M, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kalviainen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SMet al., 2010, Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study, BRAIN, Vol: 133, Pages: 2136-2147, ISSN: 0006-8950

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00501273&limit=30&person=true&page=7&respub-action=search.html