585 results found
Owen DR, Rabiner EA, Gunn RN, et al., 2010, PBR28, PBR06 and PBR111 bind two distinct TSPO sites in human brain tissue, 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S30-S31, ISSN: 1053-8119
Kasperaviciute D, Catarino CB, Heinzen EL, et al., 2010, Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study, Brain, Vol: 133, Pages: 2136-2147, ISSN: 1460-2156
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio <1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.
Zarei M, Patenaude B, Damoiseaux J, et al., 2010, Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease (vol 49, pg 1, 2010), NEUROIMAGE, Vol: 51, Pages: 940-940, ISSN: 1053-8119
Heinzen EL, Radtke RA, Urban TJ, et al., 2010, Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 86, Pages: 707-718, ISSN: 0002-9297
Pomeroy IM, Jordan EK, Frank JA, et al., 2010, Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 16, Pages: 537-548, ISSN: 1352-4585
Matthews PM, 2010, IMAGING FOR TRANSLATIONAL PHARMACOLOGY, IRISH JOURNAL OF MEDICAL SCIENCE, Vol: 179, Pages: S99-S100, ISSN: 0021-1265
Tzimopoulou S, Cunningham VJ, Nichols TE, et al., 2010, A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [F-18]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease, JOURNAL OF ALZHEIMERS DISEASE, Vol: 22, Pages: 1241-1256, ISSN: 1387-2877
Antoniades A, Matthews PM, Pattichis CS, et al., 2010, A Computationally Fast Measure Of Epistasis For 2 SNPs And A Categorical Phenotype, 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Pages: 6194-6197, ISSN: 1557-170X
Giorgio A, Watkins KE, Chadwick M, et al., 2010, Longitudinal changes in grey and white matter during adolescence, NEUROIMAGE, Vol: 49, Pages: 94-103, ISSN: 1053-8119
Zarei M, Patenaude B, Damoiseaux J, et al., 2010, Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease, NEUROIMAGE, Vol: 49, Pages: 1-8, ISSN: 1053-8119
Nalbantian S, Matthews PM, McClelland JL, 2010, The Memory Process, Publisher: Mit Pr, ISBN: 9780262014571
The convergence of neuroscience, philosophy, art, music, and literature offers valuablenew insights into the study of memory.
Owen DR, Howell OW, Tang SP, et al., 2010, Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation, J Cereb Blood Flow Metab, Vol: 30, Pages: 1608-1618, ISSN: 1559-7016
[(11)C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not been reported for [(11)C]PK11195, another TSPO radioligand. We measured the specific binding signals with [(3)H]PK11195 and [(3)H]PBR28 in brain tissue from 22 donors. Overall, 23% of the samples did not generate a visually detectable specific autoradiographic signal with [(3)H]PBR28, although all samples showed [(3)H]PK11195 binding. There was a marked reduction in the affinity of [(3)H]PBR28 for TSPO in samples with no visible [(3)H]PBR28 autoradiographic signal (K(i)=188+/-15.6 nmol/L), relative to those showing normal signal (K(i)=3.4+/-0.5 nmol/L, P<0.001). Of this latter group, [(3)H]PBR28 bound with a two-site fit in 40% of cases, with affinities (K(i)) of 4.0+/-2.4 nmol/L (high-affinity site) and 313+/-77 nmol/L (low-affinity site). There was no difference in K(d) or B(max) for [(3)H]PK11195 in samples showing no [(3)H]PBR28 autoradiographic signal relative to those showing normal [(3)H]PBR28 autoradiographic signal. [(3)H]PK11195 bound with a single site for all samples. The existence of three different binding patterns with PBR28 (high-affinity binding (46%), low-affinity binding (23%), and two-site binding (31%)) suggests that a reduction in [(11)C]PBR28 binding may not be interpreted simply as a reduction in TSPO density. The functional significance of differences in binding characteristics warrants further investigation.
Voets NL, Adcock JE, Stacey R, et al., 2009, Functional and Structural Changes in the Memory Network Associated with Left Temporal Lobe Epilepsy, HUMAN BRAIN MAPPING, Vol: 30, Pages: 4070-4081, ISSN: 1065-9471
Tomassini V, Johansen-Berg H, Leonardi L, et al., 2009, MOTOR SKILL LEARNING IN MULTIPLE SCLEROSIS, Joint Annual Meeting of the Association-of-British-Neurologists/Spanish-Society-of-Neurology, Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Matthews PM, Comley R, 2009, Advances in the molecular imaging of multiple sclerosis, EXPERT REVIEW OF CLINICAL IMMUNOLOGY, Vol: 5, Pages: 765-777, ISSN: 1744-666X
Matthews PM, 2009, Pharmacological applications of fMRI, ISBN: 9781603279185
Modern drug development presents new challenges by the unmet medical needs of chronic neurological and psychiatric disease. Imaging provides a potentially powerful tool for more efficiently translating pre-clinical and clinical studies and enhancing confidence in progression through early phase clinical development. Pharmacological MRI (phMRI) refers specifically to the applications of fMRI methods for direct or indirect measures of drug action. phMRI can be coupled to advanced structural methods to relate pharmacological effects and functional anatomy. Current and potential applications of phMRI to target stratification, patient validation, and pharmacodynamic studies are described. While great new opportunities could arise from extension of these methods as surrogate markers of clinical responses, this review highlights the substantial additional work that would need to be done to make this feasible. The review concludes that there is a strong rational for investment in phMRI for early phase clinical development, but that the short- to medium-term impact on late phase clinical development likely will be modest. © 2009 Humana Press.
Zarei M, Menke RA, Scholz J, et al., 2009, Multimodal MR imaging of substantia nigra in Parkinson's disease, 19th World Congress of Neurology, Publisher: ELSEVIER SCIENCE BV, Pages: S293-S293, ISSN: 0022-510X
Stagg CJ, O'Shea J, Kincses ZT, et al., 2009, Modulation of movement-associated cortical activation by transcranial direct current stimulation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 30, Pages: 1412-1423, ISSN: 0953-816X
Douaud G, Mackay C, Andersson J, et al., 2009, Schizophrenia delays and alters maturation of the brain in adolescence, BRAIN, Vol: 132, Pages: 2437-2448, ISSN: 0006-8950
Menke RA, Scholz J, Miller KL, et al., 2009, MRI characteristics of the substantia nigra in Parkinson's disease: A combined quantitative T1 and DTI study, NEUROIMAGE, Vol: 47, Pages: 435-441, ISSN: 1053-8119
Rocca MA, Absinta M, Valsasina P, et al., 2009, Abnormal Connectivity of the Sensorimotor Network in Patients With MS: A MultiCenter fMRI Study, HUMAN BRAIN MAPPING, Vol: 30, Pages: 2412-2425, ISSN: 1065-9471
Cader S, Palace J, Matthews PM, 2009, Cholinergic agonism alters cognitive processing and enhances brain functional connectivity in patients with multiple sclerosis, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 23, Pages: 686-696, ISSN: 0269-8811
Inkster B, Nichols TE, Saemann PG, et al., 2009, Association of GSK3 beta Polymorphisms With Brain Structural Changes in Major Depressive Disorder, ARCHIVES OF GENERAL PSYCHIATRY, Vol: 66, Pages: 721-728, ISSN: 0003-990X
De Jager PL, Jia X, Wang J, et al., 2009, Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci, NATURE GENETICS, Vol: 41, Pages: 776-U26, ISSN: 1061-4036
Enzinger C, Dawes H, Johansen-Berg H, et al., 2009, Brain Activity Changes Associated With Treadmill Training After Stroke, STROKE, Vol: 40, Pages: 2460-2467, ISSN: 0039-2499
Stagg CJ, Wylezinska M, Matthews PM, et al., 2009, Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy, JOURNAL OF NEUROPHYSIOLOGY, Vol: 101, Pages: 2872-2877, ISSN: 0022-3077
Filippi M, Rocca MA, Absinta M, et al., 2009, Functional connectivity changes of the motor network in patients with multiple sclerosis: a multi-centre fMRI study, 19th Meeting of the European-Neurological-Society, Publisher: DR DIETRICH STEINKOPFF VERLAG, Pages: S47-S48, ISSN: 0340-5354
Filippini N, MacIntosh BJ, Hough MG, et al., 2009, Distinct patterns of brain activity in young carriers of the APOE-epsilon 4 allele, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 7209-7214, ISSN: 0027-8424
Stagg CJ, Best JG, Stephenson MC, et al., 2009, Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation, JOURNAL OF NEUROSCIENCE, Vol: 29, Pages: 5202-5206, ISSN: 0270-6474
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