Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Alison Thomas +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

576 results found

Antoniades A, Kalvari I, Pattichis C, Jones N, Matthews PM, Domenici E, Muglia Pet al., 2009, Discovering genetic polymorphism associated with gene expression levels across the whole genome., 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20, Pages: 5466-+, ISSN: 1557-170X

JOURNAL ARTICLE

Antoniades A, Kalvari I, Pattichis C, Jones N, Matthews PM, Domenici E, Muglia Pet al., 2009, Discovering genetic polymorphism associated with gene expression levels across the whole genome, Pages: 5466-5469

Genetic differences have been shown to contribute to gene expression variability. A complete evaluation of the associations between a whole genome scan with 550k Single Nucleotide Polymorphisms (SNPs) and 54k detectable expression levels (probesets) was performed on 176 human peripheral blood samples. The results are presented along with visualizations that reveal cis and trans gene expression regulatory effects. The algorithmic approach followed utilized a distributed computational system. The analysis was performed using a linear regression adjusting for all relevant covariates. Permutation testing on a random subset of the top results provided an indication of the significance levels adjusted for multiple testing and the non independence of SNPs due to linkage disequilibrium. The database of the produced results can be used as a resource to assess the functional impact of genetic polymorphisms to gene expression regulation. This resource is applicable across all disease areas. ©2009 IEEE.

CONFERENCE PAPER

Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BMJ, Kappos L, Polman CH, Matthews PM, Hauser SL, Gibson RA, Oksenberg JR, Barnes MRet al., 2009, Pathway and network-based analysis of genome-wide association studies in multiple sclerosis, HUMAN MOLECULAR GENETICS, Vol: 18, Pages: 2078-2090, ISSN: 0964-6906

JOURNAL ARTICLE

Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue E-W, Lindberg RLP, Uitdehaag BMG, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJG, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BAC, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JRet al., 2009, Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis, HUMAN MOLECULAR GENETICS, Vol: 18, Pages: 767-778, ISSN: 0964-6906

JOURNAL ARTICLE

Bendfeldt K, Kuster P, Traud S, Egger H, Winklhofer S, Mueller-Lenke N, Naegelin Y, Gass A, Kappos L, Matthews PM, Nichols TE, Radue E-W, Borgwardt SJet al., 2009, Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis - A longitudinal voxel-based morphometry study, NEUROIMAGE, Vol: 45, Pages: 60-67, ISSN: 1053-8119

JOURNAL ARTICLE

Bosnell RA, Kincses T, Kischka U, Matthews PM, Johansen-Berg Het al., 2009, DTI MEASURES OF WHITE MATTER INTEGRITY PREDICT RESPONSE TO MOTOR TRAINING POST STROKE, Spring Scientific Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 118-119, ISSN: 0022-3050

CONFERENCE PAPER

Cader S, Palace J, Matthews PM, 2009, Cholinergic agonism alters cognitive processing and enhances brain functional connectivity in patients with multiple sclerosis, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 23, Pages: 686-696, ISSN: 0269-8811

JOURNAL ARTICLE

Ciccarelli O, Behrens TE, Johansen-Berg H, Talbot K, Orrell RW, Howard RS, Nunes RG, Miller DH, Matthews PM, Thompson AJ, Smith SMet al., 2009, Investigation of White Matter Pathology in ALS and PLS Using Tract-Based Spatial Statistics, HUMAN BRAIN MAPPING, Vol: 30, Pages: 615-624, ISSN: 1065-9471

JOURNAL ARTICLE

De Jager PL, Jia X, Wang J, de Bakker PIW, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JRet al., 2009, Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci, NATURE GENETICS, Vol: 41, Pages: 776-U26, ISSN: 1061-4036

JOURNAL ARTICLE

Douaud G, Mackay C, Andersson J, James S, Quested D, Ray MK, Connell J, Roberts N, Crow TJ, Matthews PM, Smith S, James Aet al., 2009, Schizophrenia delays and alters maturation of the brain in adolescence, BRAIN, Vol: 132, Pages: 2437-2448, ISSN: 0006-8950

JOURNAL ARTICLE

Enzinger C, Dawes H, Johansen-Berg H, Wade D, Bogdanovic M, Collett J, Guy C, Kischka U, Ropele S, Fazekas F, Matthews PMet al., 2009, Brain Activity Changes Associated With Treadmill Training After Stroke, STROKE, Vol: 40, Pages: 2460-2467, ISSN: 0039-2499

JOURNAL ARTICLE

Filippi M, Rocca MA, Absinta M, Valsasina P, Ciccarelli O, Marino S, Rovira A, Gass A, Wegner C, Enzinger C, Korteweg T, Mancini L, Thompson A, De Stefano N, Montalban X, Hirsch J, Kappos L, Ropele S, Palace J, Barkhof F, Yousry T, Matthews PMet al., 2009, Functional connectivity changes of the motor network in patients with multiple sclerosis: a multi-centre fMRI study, 19th Meeting of the European-Neurological-Society, Publisher: DR DIETRICH STEINKOPFF VERLAG, Pages: S47-S48, ISSN: 0340-5354

CONFERENCE PAPER

Filippini N, MacIntosh BJ, Hough MG, Goodwin GM, Frisoni GB, Smith SM, Matthews PM, Beckmann CF, Mackay CEet al., 2009, Distinct patterns of brain activity in young carriers of the APOE-epsilon 4 allele, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 7209-7214, ISSN: 0027-8424

JOURNAL ARTICLE

Filippini N, Rao A, Wetten S, Gibson RA, Borrie M, Guzman D, Kertesz A, Loy-English I, Williams J, Nichols T, Whitcher B, Matthews PMet al., 2009, Anatomically-distinct genetic associations of APOE epsilon 4 allele load with regional cortical atrophy in Alzheimer's disease, NEUROIMAGE, Vol: 44, Pages: 724-728, ISSN: 1053-8119

JOURNAL ARTICLE

Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PMet al., 2009, Association of GSK3 beta Polymorphisms With Brain Structural Changes in Major Depressive Disorder, ARCHIVES OF GENERAL PSYCHIATRY, Vol: 66, Pages: 721-728, ISSN: 0003-990X

JOURNAL ARTICLE

Lin X, Song K, Lim N, Yuan X, Johnson T, Abderrahmani A, Vollenweider P, Stirnadel H, Sundseth SS, Lai E, Burns DK, Middleton LT, Roses AD, Matthews PM, Waeber G, Cardon L, Waterworth DM, Mooser Vet al., 2009, Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score-the CoLaus Study, DIABETOLOGIA, Vol: 52, Pages: 600-608, ISSN: 0012-186X

JOURNAL ARTICLE

Long CJ, Cole DM, Durcan MJ, Matthews PM, Beaver JDet al., 2009, DYNAMIC IMAGING OF COGNITIVE IMPAIRMENT IN NICOTINE-DEPRIVED SUBJECTS USING SIMULTANEOUS EEG/FMRI, IEEE International Symposium on Biomedical Imaging - From Nano to Macro, Publisher: IEEE, Pages: 646-+

CONFERENCE PAPER

Mancini L, Ciccarelli O, Manfredonia F, Thornton JS, Agosta F, Barkhof F, Beckmann C, De Stefano N, Enzinger C, Fazekas F, Filippi M, Gass A, Hirsch JG, Johansen-Berg H, Kappos L, Korteweg T, Manson SC, Marino S, Matthews PM, Montalban X, Palace J, Polman C, Rocca M, Ropele S, Rovira A, Wegner C, Friston KJ, Thompson A, Yousry Tet al., 2009, Short-term adaptation to a simple motor task: A physiological process preserved in multiple sclerosis, NEUROIMAGE, Vol: 45, Pages: 500-511, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, 2009, Brain Imaging of Multiple Sclerosis: the Next 10 Years, NEUROIMAGING CLINICS OF NORTH AMERICA, Vol: 19, Pages: 101-+, ISSN: 1052-5149

JOURNAL ARTICLE

Matthews PM, 2009, Pharmacological applications of fMRI, ISBN: 9781603279185

Modern drug development presents new challenges by the unmet medical needs of chronic neurological and psychiatric disease. Imaging provides a potentially powerful tool for more efficiently translating pre-clinical and clinical studies and enhancing confidence in progression through early phase clinical development. Pharmacological MRI (phMRI) refers specifically to the applications of fMRI methods for direct or indirect measures of drug action. phMRI can be coupled to advanced structural methods to relate pharmacological effects and functional anatomy. Current and potential applications of phMRI to target stratification, patient validation, and pharmacodynamic studies are described. While great new opportunities could arise from extension of these methods as surrogate markers of clinical responses, this review highlights the substantial additional work that would need to be done to make this feasible. The review concludes that there is a strong rational for investment in phMRI for early phase clinical development, but that the short- to medium-term impact on late phase clinical development likely will be modest. © 2009 Humana Press.

BOOK

Matthews PM, Comley R, 2009, Advances in the molecular imaging of multiple sclerosis, EXPERT REVIEW OF CLINICAL IMMUNOLOGY, Vol: 5, Pages: 765-777, ISSN: 1744-666X

JOURNAL ARTICLE

Menke RA, Scholz J, Miller KL, Deoni S, Jbabdi S, Matthews PM, Zarei Met al., 2009, MRI characteristics of the substantia nigra in Parkinson's disease: A combined quantitative T1 and DTI study, NEUROIMAGE, Vol: 47, Pages: 435-441, ISSN: 1053-8119

JOURNAL ARTICLE

Rocca MA, Absinta M, Valsasina P, Ciccarelli O, Marino S, Rovira A, Gass A, Wegner C, Enzinger C, Korteweg T, Sormani MP, Mancini L, Thompson AJ, De Stefano N, Montalban X, Hirsch J, Kappos L, Ropele S, Palace J, Barkhof F, Matthews PM, Filippi Met al., 2009, Abnormal Connectivity of the Sensorimotor Network in Patients With MS: A MultiCenter fMRI Study, HUMAN BRAIN MAPPING, Vol: 30, Pages: 2412-2425, ISSN: 1065-9471

JOURNAL ARTICLE

Stagg CJ, Best JG, Stephenson MC, O'Shea J, Wylezinska M, Kincses ZT, Morris PG, Matthews PM, Johansen-Berg Het al., 2009, Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation, JOURNAL OF NEUROSCIENCE, Vol: 29, Pages: 5202-5206, ISSN: 0270-6474

JOURNAL ARTICLE

Stagg CJ, O'Shea J, Kincses ZT, Woolrich M, Matthews PM, Johansen-Berg Het al., 2009, Modulation of movement-associated cortical activation by transcranial direct current stimulation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 30, Pages: 1412-1423, ISSN: 0953-816X

JOURNAL ARTICLE

Stagg CJ, Wylezinska M, Matthews PM, Johansen-Berg H, Jezzard P, Rothwell JC, Bestmann Set al., 2009, Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy, JOURNAL OF NEUROPHYSIOLOGY, Vol: 101, Pages: 2872-2877, ISSN: 0022-3077

JOURNAL ARTICLE

Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietilainen OPH, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Borglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Bottcher Y, Olesen J, Breuer R, Moeller H-J, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Rethelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Mason G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Joensson EG, Terenius L, Agartz I, Petursson H, Nothen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DAet al., 2009, Common variants conferring risk of schizophrenia, NATURE, Vol: 460, Pages: 744-U99, ISSN: 0028-0836

JOURNAL ARTICLE

Tamas KZ, Johansen-Berg H, Tomassini V, Bosnell R, Matthews PM, Beckmann CFet al., 2009, THE BRAIN INVOLVED IN MOTOR SEQUENCE LEARNING NETWORKS IDENTIFICATION MODEL WITH FMR-DATA ANALYSIS Peter Mihaly, IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE, Vol: 62, Pages: 66-67, ISSN: 0019-1442

JOURNAL ARTICLE

Tomassini V, Johansen-Berg H, Leonardi L, Palace J, Pozzilli C, Matthews PMet al., 2009, MOTOR SKILL LEARNING IN MULTIPLE SCLEROSIS, ABN Joint Annual Meeting/Spanish-Society-of-Neurology, Publisher: B M J PUBLISHING GROUP, ISSN: 0022-3050

CONFERENCE PAPER

Voets NL, Adcock JE, Stacey R, Hart Y, Carpenter K, Matthews PM, Beckmann CFet al., 2009, Functional and Structural Changes in the Memory Network Associated with Left Temporal Lobe Epilepsy, HUMAN BRAIN MAPPING, Vol: 30, Pages: 4070-4081, ISSN: 1065-9471

JOURNAL ARTICLE

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