Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

585 results found

Mancini L, Ciccarelli O, Manfredonia F, Thornton JS, Agosta F, Barkhof F, Beckmann C, De Stefano N, Enzinger C, Fazekas F, Filippi M, Gass A, Hirsch JG, Johansen-Berg H, Kappos L, Korteweg T, Manson SC, Marino S, Matthews PM, Montalban X, Palace J, Polman C, Rocca M, Ropele S, Rovira A, Wegner C, Friston KJ, Thompson A, Yousry Tet al., 2009, Short-term adaptation to a simple motor task: A physiological process preserved in multiple sclerosis, NEUROIMAGE, Vol: 45, Pages: 500-511, ISSN: 1053-8119

JOURNAL ARTICLE

Lin X, Song K, Lim N, Yuan X, Johnson T, Abderrahmani A, Vollenweider P, Stirnadel H, Sundseth SS, Lai E, Burns DK, Middleton LT, Roses AD, Matthews PM, Waeber G, Cardon L, Waterworth DM, Mooser Vet al., 2009, Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score-the CoLaus Study, DIABETOLOGIA, Vol: 52, Pages: 600-608, ISSN: 0012-186X

JOURNAL ARTICLE

Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BMJ, Kappos L, Polman CH, Matthews PM, Hauser SL, Gibson RA, Oksenberg JR, Barnes MRet al., 2009, Pathway and network-based analysis of genome-wide association studies in multiple sclerosis, HUMAN MOLECULAR GENETICS, Vol: 18, Pages: 2078-2090, ISSN: 0964-6906

Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed inmultiple sclerosis (MS) and other complex diseases. Typically, the number of markers in which the evidencefor association exceeds the genome-wide significance threshold is very small, and markers that do notexceed this threshold are generally neglected. Classical statistical analysis of these datasets in MS revealedgenes with known immunological functions. However, many of the markers showing modest associationmay represent false negatives. We hypothesize that certain combinations of genes flagged by these markerscan be identified if they belong to a common biological pathway. Here we conduct a pathway-oriented analysisof two GWAS in MS that takes into account all SNPs with nominal evidence of association (P<0.05). Gene-wiseP-values were superimposed on a human protein interaction network and searches were conducted to identifysub-networks containing a higher proportion of genes associated with MS than expected by chance. Thesesub-networks, and others generated at random as a control, were categorized for membership of biologicalpathways. GWAS from eight other diseases were analyzed to assess the specificity of the pathways identified.In the MS datasets, we identified sub-networks of genes from several immunological pathways including celladhesion, communication and signaling. Remarkably, neural pathways, namely axon-guidance and synapticpotentiation, were also over-represented in MS. In addition to the immunological pathways previously ident-ified, we report here for the first time the potential involvement of neural pathways in MS susceptibility.

JOURNAL ARTICLE

Zarei M, Damoiseaux JS, Morgese C, Beckmann CF, Smith SM, Matthews PM, Scheltens P, Rombouts SARB, Barkhof Fet al., 2009, Regional White Matter Integrity Differentiates Between Vascular Dementia and Alzheimer Disease, STROKE, Vol: 40, Pages: 773-779, ISSN: 0039-2499

JOURNAL ARTICLE

Bendfeldt K, Kuster P, Traud S, Egger H, Winklhofer S, Mueller-Lenke N, Naegelin Y, Gass A, Kappos L, Matthews PM, Nichols TE, Radue E-W, Borgwardt SJet al., 2009, Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis - A longitudinal voxel-based morphometry study, NEUROIMAGE, Vol: 45, Pages: 60-67, ISSN: 1053-8119

JOURNAL ARTICLE

Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue E-W, Lindberg RLP, Uitdehaag BMG, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJG, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BAC, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JRet al., 2009, Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis, HUMAN MOLECULAR GENETICS, Vol: 18, Pages: 767-778, ISSN: 0964-6906

JOURNAL ARTICLE

Matthews PM, 2009, Brain Imaging of Multiple Sclerosis: the Next 10 Years, NEUROIMAGING CLINICS OF NORTH AMERICA, Vol: 19, Pages: 101-+, ISSN: 1052-5149

JOURNAL ARTICLE

Filippini N, Rao A, Wetten S, Gibson RA, Borrie M, Guzman D, Kertesz A, Loy-English I, Williams J, Nichols T, Whitcher B, Matthews PMet al., 2009, Anatomically-distinct genetic associations of APOE epsilon 4 allele load with regional cortical atrophy in Alzheimer's disease, NEUROIMAGE, Vol: 44, Pages: 724-728, ISSN: 1053-8119

JOURNAL ARTICLE

Ciccarelli O, Behrens TE, Johansen-Berg H, Talbot K, Orrell RW, Howard RS, Nunes RG, Miller DH, Matthews PM, Thompson AJ, Smith SMet al., 2009, Investigation of White Matter Pathology in ALS and PLS Using Tract-Based Spatial Statistics, HUMAN BRAIN MAPPING, Vol: 30, Pages: 615-624, ISSN: 1065-9471

JOURNAL ARTICLE

Tamas KZ, Johansen-Berg H, Tomassini V, Bosnell R, Matthews PM, Beckmann CFet al., 2009, THE BRAIN INVOLVED IN MOTOR SEQUENCE LEARNING NETWORKS IDENTIFICATION MODEL WITH FMR-DATA ANALYSIS Peter Mihaly, IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE, Vol: 62, Pages: 66-67, ISSN: 0019-1442

JOURNAL ARTICLE

Long CJ, Cole DM, Durcan MJ, Matthews PM, Beaver JDet al., 2009, DYNAMIC IMAGING OF COGNITIVE IMPAIRMENT IN NICOTINE-DEPRIVED SUBJECTS USING SIMULTANEOUS EEG/FMRI, IEEE International Symposium on Biomedical Imaging - From Nano to Macro, Publisher: IEEE, Pages: 646-+

CONFERENCE PAPER

Antoniades A, Kalvari I, Pattichis C, Jones N, Matthews PM, Domenici E, Muglia Pet al., 2009, Discovering genetic polymorphism associated with gene expression levels across the whole genome, Pages: 5466-5469

Genetic differences have been shown to contribute to gene expression variability. A complete evaluation of the associations between a whole genome scan with 550k Single Nucleotide Polymorphisms (SNPs) and 54k detectable expression levels (probesets) was performed on 176 human peripheral blood samples. The results are presented along with visualizations that reveal cis and trans gene expression regulatory effects. The algorithmic approach followed utilized a distributed computational system. The analysis was performed using a linear regression adjusting for all relevant covariates. Permutation testing on a random subset of the top results provided an indication of the significance levels adjusted for multiple testing and the non independence of SNPs due to linkage disequilibrium. The database of the produced results can be used as a resource to assess the functional impact of genetic polymorphisms to gene expression regulation. This resource is applicable across all disease areas. ©2009 IEEE.

CONFERENCE PAPER

Antoniades A, Kalvari I, Pattichis C, Jones N, Matthews PM, Domenici E, Muglia Pet al., 2009, Discovering genetic polymorphism associated with gene expression levels across the whole genome., 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20, Pages: 5466-+, ISSN: 1557-170X

JOURNAL ARTICLE

Bosnell RA, Kincses T, Kischka U, Matthews PM, Johansen-Berg Het al., 2009, DTI MEASURES OF WHITE MATTER INTEGRITY PREDICT RESPONSE TO MOTOR TRAINING POST STROKE, Spring Scientific Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 118-119, ISSN: 0022-3050

CONFERENCE PAPER

Knouff CW, Lim N, Song K, Yuan X, Walker MC, Townsend R, Waeber G, Matthews PM, Vollenweider P, Waterworth DM, Mooser Vet al., 2008, Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target, genes, PHARMACOGENETICS AND GENOMICS, Vol: 18, Pages: 1051-1057, ISSN: 1744-6872

JOURNAL ARTICLE

Voets NL, Hough MG, Douaud G, Matthews PM, James A, Winmill L, Webster P, Smith Set al., 2008, Evidence for abnormalities of cortical development in adolescent-onset schizophrenia, NEUROIMAGE, Vol: 43, Pages: 665-675, ISSN: 1053-8119

JOURNAL ARTICLE

Matthews PM, 2008, Approaching a renaissance in coma research responsibly, NATURE CLINICAL PRACTICE NEUROLOGY, Vol: 4, Pages: 523-523, ISSN: 1745-834X

JOURNAL ARTICLE

Ishihara-Paul L, Hulihan MM, Kachergus J, Upmanyu R, Warren L, Amouri R, Elango R, Prinjha RK, Soto A, Kefi M, Zouari M, Sassi SB, Yahmed SB, El Euch-Fayeche G, Matthews PM, Middleton LT, Gibson RA, Hentati F, Farrer MJet al., 2008, PINK1 mutations and parkinsonism, NEUROLOGY, Vol: 71, Pages: 896-902, ISSN: 0028-3878

JOURNAL ARTICLE

Matthews PM, Radda GK, Johansen-Berg H, Tracey I, Cowey Aet al., 2008, Remembering John Newsom-Davis' contribution to human imaging in Oxford, JOURNAL OF NEUROIMMUNOLOGY, Vol: 201, Pages: 250-254, ISSN: 0165-5728

JOURNAL ARTICLE

Stefansson H, Rujescu D, Cichon S, Pietilainen OPH, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Moeller H-J, Hartmann A, Shianna KV, Ge D, Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Muehleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Noethen MM, Peltonen L, Collier DA, St Clair D, Stefansson Ket al., 2008, Large recurrent microdeletions associated with schizophrenia, NATURE, Vol: 455, Pages: 232-U61, ISSN: 0028-0836

JOURNAL ARTICLE

Bendfeldt K, Kuster P, Traud S, Egger H, Winklhofer S, Mueller-Lenke N, Naegelin Y, Gass A, Kappos L, Matthews PM, Nichols TE, Radue E-W, Borgwardt SJet al., 2008, Association of regional gray matter volume loss and progressive white matter lesions in multiple sclerosis, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S95-S96, ISSN: 1352-4585

CONFERENCE PAPER

Bosnell R, Wegner C, Kincses ZT, Korteweg T, Agosta F, Ciccarelli O, De Stefano N, Gass A, Hirsch J, Johansen-Berg H, Kappos L, Barkhof F, Mancini L, Manfredonia F, Marino S, Miller DH, Montalban X, Palace J, Rocca M, Enzinger C, Ropele S, Rovira A, Smith S, Thompson A, Thornton J, Yousry T, Whitcher B, Filippi M, Matthews PMet al., 2008, Reproducibility of fMRI in the clinical setting: Implications for trial designs, NEUROIMAGE, Vol: 42, Pages: 603-610, ISSN: 1053-8119

JOURNAL ARTICLE

Hulihan MM, Ishihara-Paul L, Kochergus J, Warren L, Amouri R, Elango R, Prinjha RK, Upmanyu R, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, El Euch-Fayeche G, Matthews PM, Middleton LT, Gibson RA, Hentati F, Farrer MJet al., 2008, LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study, LANCET NEUROLOGY, Vol: 7, Pages: 591-594, ISSN: 1474-4422

JOURNAL ARTICLE

Johansen-Berg H, Gutman DA, Behrens TEJ, Matthews PM, Rushworth MFS, Katz E, Lozano AM, Mayberg HSet al., 2008, Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression, CEREBRAL CORTEX, Vol: 18, Pages: 1374-1383, ISSN: 1047-3211

JOURNAL ARTICLE

Rocca M, Absinta M, Valsasina P, Ciccarelli O, Thompson AJ, Mancini L, Marino S, De Stefano N, Rovira A, Montalban X, Gass A, Kappos L, Wegner C, Enzinger C, Ropele S, Korteweg T, Barkhof F, Matthews PM, Filippi Met al., 2008, Abnormal connectivity inside the motor network in patients with multiple sclerosis: a multicentre fMRI study, 18th Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: 8-8, ISSN: 0340-5354

CONFERENCE PAPER

Pomeroy IM, Jordan EK, Frank JA, Matthews PM, Esiri MMet al., 2008, Diffuse cortical atrophy in a marmoset model of multiple sclerosis, NEUROSCIENCE LETTERS, Vol: 437, Pages: 121-124, ISSN: 0304-3940

JOURNAL ARTICLE

Enzinger C, Johansen-Berg H, Dawes H, Bogdanovic M, Collett J, Guy C, Ropele S, Kischka U, Wade D, Fazekas F, Matthews PMet al., 2008, Functional MRI correlates of lower limb function in stroke victims with gait impairment, STROKE, Vol: 39, Pages: 1507-1513, ISSN: 0039-2499

JOURNAL ARTICLE

Manson SC, Wegner C, Filippi M, Barkhof F, Beckmann C, Ciccarelli O, De Stefano N, Enzinger C, Fazekas F, Agosta F, Gass A, Hirsch J, Johansen-Berg H, Kappos L, Korteweg T, Polman C, Mancini L, Manfredonia F, Marino S, Miller DH, Montalban X, Palace J, Rocca M, Ropele S, Rovira A, Smith S, Thompson A, Thornton J, Yousry T, Frank JA, Matthews PMet al., 2008, Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition, EXPERIMENTAL BRAIN RESEARCH, Vol: 187, Pages: 25-31, ISSN: 0014-4819

JOURNAL ARTICLE

Allen HA, Humphreys GW, Matthews PM, 2008, A neural marker of content-specific active ignoring, JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE, Vol: 34, Pages: 286-297, ISSN: 0096-1523

JOURNAL ARTICLE

Dawes H, Enzinger C, Johansen-Berg H, Bogdanovic M, Guy C, Collett J, Izadi H, Stagg C, Wade D, Matthews PMet al., 2008, Walking performance and its recovery in chronic stroke in relation to extent of lesion overlap with the descending motor tract, EXPERIMENTAL BRAIN RESEARCH, Vol: 186, Pages: 325-333, ISSN: 0014-4819

JOURNAL ARTICLE

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