Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Venkataraman:10.1177/0271678X19850985,
author = {Venkataraman, A and Mansur, A and Lewis, Y and Kocagoncu, E and Lingford-Hughes, A and Huiban, M and Passchier, J and Rowe, J and Tsukada, H and Brooks, D and Gunn, R and Matthews, P and Rabiner, E and MINDMAPS, Consortium},
doi = {10.1177/0271678X19850985},
journal = {Journal of Cerebral Blood Flow and Metabolism},
pages = {121--122},
title = {Evaluation of mitochondrial and synaptic function in Alzheimer’s disease (AD): a [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J PET study},
url = {http://dx.doi.org/10.1177/0271678X19850985},
volume = {39},
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - ObjectivesMitochondrial deficits leading to synaptic dysfunction have been hypothesised in the pathophysiology of neurodegenerative disease, with Aβ/tau impairing mitochondrial function in AD. To date a combined evaluation of human mitochondrial and synaptic function has not been performed directly in vivo. We describe the pilot results of MINDMAPS-AD, a study within the MINDMAPS1 programme aiming to evaluate mitochondrial and synaptic function in the brain of patients with MCI/AD. MINDMAPS-AD uses the novel radioligands [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J, to compare the regional density of mitochondrial complex I (MC1), the sigma 1 receptor (s1R) and synaptic vesicular protein 2A (SV2A) respectively.MethodsSix participants with a range of AD related pathologies, EMCI (n = 2), LMCI (n = 2), and AD (n = 2), were enrolled into the study. Participants fulfilled NIA-AA criteria and were amyloid-beta +ve confirmed by [18F]Florbetaben PET. All participants underwent three PET scans with [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J. Arterial blood samples were collected and a metabolite corrected arterial plasma input function was estimated to derive regional volumes of distribution (VT). These data were compared to six age/sex matched cognitively normal (CN) healthy subjects recruited for ongoing studies within the MINDMAPS programme. Regions of interest (ROIs) were defined on individual subject MR images using an anatomical atlas and included: frontal cortex, hippocampus, amygdala, anterior cingulate, posterior cingulate, thalamus, temporal cortex, parietal cortex, caudate, putamen, and occipital lobe. Regional target density was evaluated using the VT, as well as VT corrected for the plasma free fraction of the radioligand (fP; VT/fp), and the regional VT ratio versus the VT in the centrum semiovale, a white matter region expected to have low levels of the targets evaluated (DVR). Comparison of regional target density and
AU - Venkataraman,A
AU - Mansur,A
AU - Lewis,Y
AU - Kocagoncu,E
AU - Lingford-Hughes,A
AU - Huiban,M
AU - Passchier,J
AU - Rowe,J
AU - Tsukada,H
AU - Brooks,D
AU - Gunn,R
AU - Matthews,P
AU - Rabiner,E
AU - MINDMAPS,Consortium
DO - 10.1177/0271678X19850985
EP - 122
SN - 1559-7016
SP - 121
TI - Evaluation of mitochondrial and synaptic function in Alzheimer’s disease (AD): a [18F]BCPP-EF, [11C]SA4503 and [11C]UCB-J PET study
T2 - Journal of Cerebral Blood Flow and Metabolism
UR - http://dx.doi.org/10.1177/0271678X19850985
UR - https://journals.sagepub.com/doi/10.1177/0271678X19850985
VL - 39
ER -