Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair, Head of Department



+44 (0)20 7594 2855p.matthews




Ms Siobhan Dillon +44 (0)20 7594 2855




E502Burlington DanesHammersmith Campus






BibTex format

author = {Bauermeister, S and Orton, C and Thompson, S and Barker, RA and Bauermeister, JR and Ben-Shlomo, Y and Brayne, C and Burn, D and Campbell, A and Calvin, C and Chandran, S and Chaturvedi, N and Chene, G and Chessell, IP and Corbett, A and Davis, DHJ and Denis, M and Dufouil, C and Elliott, P and Fox, N and Hill, D and Hofer, SM and Hu, MT and Jindra, C and Kee, F and Kim, C-H and Kim, C and Kivimaki, M and Koychev, I and Lawson, RA and Linden, GJ and Lyons, RA and Mackay, C and Matthews, PM and McGuiness, B and Middleton, L and Moody, C and Moore, K and Na, DL and O'Brien, JT and Ourselin, S and Paranjothy, S and Park, K-S and Porteous, DJ and Richards, M and Ritchie, CW and Rohrer, JD and Rossor, MN and Rowe, JB and Scahill, R and Schnier, C and Schott, JM and Seo, SW and South, M and Steptoe, M and Tabrizi, SJ and Tales, A and Tillin, T and Timpson, NJ and Toga, AW and Visser, P-J and Wade-Martins, R and Wilkinson, T and Williams, J and Wong, A and Gallacher, JEJ},
doi = {10.1007/s10654-020-00633-4},
journal = {European Journal of Epidemiology},
pages = {601--611},
title = {The Dementias Platform UK (DPUK) data portal},
url = {},
volume = {35},
year = {2020}

RIS format (EndNote, RefMan)

AB - The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis. These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation. Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers. Researchers are provided with their own secure ‘lab’ using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts. Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.
AU - Bauermeister,S
AU - Orton,C
AU - Thompson,S
AU - Barker,RA
AU - Bauermeister,JR
AU - Ben-Shlomo,Y
AU - Brayne,C
AU - Burn,D
AU - Campbell,A
AU - Calvin,C
AU - Chandran,S
AU - Chaturvedi,N
AU - Chene,G
AU - Chessell,IP
AU - Corbett,A
AU - Davis,DHJ
AU - Denis,M
AU - Dufouil,C
AU - Elliott,P
AU - Fox,N
AU - Hill,D
AU - Hofer,SM
AU - Hu,MT
AU - Jindra,C
AU - Kee,F
AU - Kim,C-H
AU - Kim,C
AU - Kivimaki,M
AU - Koychev,I
AU - Lawson,RA
AU - Linden,GJ
AU - Lyons,RA
AU - Mackay,C
AU - Matthews,PM
AU - McGuiness,B
AU - Middleton,L
AU - Moody,C
AU - Moore,K
AU - Na,DL
AU - O'Brien,JT
AU - Ourselin,S
AU - Paranjothy,S
AU - Park,K-S
AU - Porteous,DJ
AU - Richards,M
AU - Ritchie,CW
AU - Rohrer,JD
AU - Rossor,MN
AU - Rowe,JB
AU - Scahill,R
AU - Schnier,C
AU - Schott,JM
AU - Seo,SW
AU - South,M
AU - Steptoe,M
AU - Tabrizi,SJ
AU - Tales,A
AU - Tillin,T
AU - Timpson,NJ
AU - Toga,AW
AU - Visser,P-J
AU - Wade-Martins,R
AU - Wilkinson,T
AU - Williams,J
AU - Wong,A
AU - Gallacher,JEJ
DO - 10.1007/s10654-020-00633-4
EP - 611
PY - 2020///
SN - 0393-2990
SP - 601
TI - The Dementias Platform UK (DPUK) data portal
T2 - European Journal of Epidemiology
UR -
UR -
UR -
UR -
VL - 35
ER -