Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department



+44 (0)20 7594 2855p.matthews




Ms Siobhan Dillon +44 (0)20 7594 2855




E502Burlington DanesHammersmith Campus






BibTex format

author = {Kasperaviciute, D and Catarino, CB and Heinzen, EL and Depondt, C and Cavalleri, GL and Caboclo, LO and Tate, SK and Jamnadas-Khoda, J and Chinthapalli, K and Clayton, LMS and Shianna, KV and Radtke, RA and Mikati, MA and Gallentine, WB and Husain, AM and Alhusaini, S and Leppert, D and Middleton, LT and Gibson, RA and Johnson, MR and Matthews, PM and Hosford, D and Heuser, K and Amos, L and Ortega, M and Zumsteg, D and Wieser, H-G and Steinhoff, BJ and Kraermer, G and Hansen, J and Dorn, T and Kantanen, A-M and Gjerstad, L and Peuralinna, T and Hernandez, DG and Eriksson, KJ and Kalviainen, RK and Doherty, CP and Wood, NW and Pandolfo, M and Duncan, JS and Sander, JW and Delanty, N and Goldstein, DB and Sisodiya, SM},
doi = {brain/awq130},
journal = {Brain},
pages = {2136--2147},
title = {Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study},
url = {},
volume = {133},
year = {2010}

RIS format (EndNote, RefMan)

AB - Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio <1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.
AU - Kasperaviciute,D
AU - Catarino,CB
AU - Heinzen,EL
AU - Depondt,C
AU - Cavalleri,GL
AU - Caboclo,LO
AU - Tate,SK
AU - Jamnadas-Khoda,J
AU - Chinthapalli,K
AU - Clayton,LMS
AU - Shianna,KV
AU - Radtke,RA
AU - Mikati,MA
AU - Gallentine,WB
AU - Husain,AM
AU - Alhusaini,S
AU - Leppert,D
AU - Middleton,LT
AU - Gibson,RA
AU - Johnson,MR
AU - Matthews,PM
AU - Hosford,D
AU - Heuser,K
AU - Amos,L
AU - Ortega,M
AU - Zumsteg,D
AU - Wieser,H-G
AU - Steinhoff,BJ
AU - Kraermer,G
AU - Hansen,J
AU - Dorn,T
AU - Kantanen,A-M
AU - Gjerstad,L
AU - Peuralinna,T
AU - Hernandez,DG
AU - Eriksson,KJ
AU - Kalviainen,RK
AU - Doherty,CP
AU - Wood,NW
AU - Pandolfo,M
AU - Duncan,JS
AU - Sander,JW
AU - Delanty,N
AU - Goldstein,DB
AU - Sisodiya,SM
DO - brain/awq130
EP - 2147
PY - 2010///
SN - 1460-2156
SP - 2136
TI - Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study
T2 - Brain
UR -
UR -
UR -
VL - 133
ER -