Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair, Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Owen:2012:10.1038/jcbfm.2011.147,
author = {Owen, DR and Yeo, AJ and Gunn, RN and Song, K and Wadsworth, G and Lewis, A and Rhodes, C and Pulford, DJ and Bennacef, I and Parker, CA and StJean, PL and Cardon, LR and Mooser, VE and Matthews, PM and Rabiner, EA and Rubio, JP},
doi = {10.1038/jcbfm.2011.147},
journal = {J Cereb Blood Flow Metab},
pages = {1--5},
title = {An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28},
url = {http://dx.doi.org/10.1038/jcbfm.2011.147},
volume = {32},
year = {2012}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - [(11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain this. Binding affinity of PBR28 was measured in platelets isolated from 41 human subjects and tested for association with polymorphisms in TSPO and genes encoding other proteins in the TSPO complex. Complete agreement was observed between the TSPO Ala147Thr genotype and PBR28 binding affinity phenotype (P value=3.1 x 10(-13)). The TSPO Ala147Thr polymorphism predicts PBR28 binding affinity in human platelets. As all second-generation TSPO PET radioligands tested hitherto display a trimodal distribution in binding affinity analogous to PBR28, testing for this polymorphism may allow quantitative interpretation of TSPO PET studies with these radioligands.
AU - Owen,DR
AU - Yeo,AJ
AU - Gunn,RN
AU - Song,K
AU - Wadsworth,G
AU - Lewis,A
AU - Rhodes,C
AU - Pulford,DJ
AU - Bennacef,I
AU - Parker,CA
AU - StJean,PL
AU - Cardon,LR
AU - Mooser,VE
AU - Matthews,PM
AU - Rabiner,EA
AU - Rubio,JP
DO - 10.1038/jcbfm.2011.147
EP - 5
PY - 2012///
SN - 1559-7016
SP - 1
TI - An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
T2 - J Cereb Blood Flow Metab
UR - http://dx.doi.org/10.1038/jcbfm.2011.147
UR - http://www.ncbi.nlm.nih.gov/pubmed/22008728
UR - http://hdl.handle.net/10044/1/18511
VL - 32
ER -