Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair, Head of Department



+44 (0)20 7594 2855p.matthews




Ms Siobhan Dillon +44 (0)20 7594 2855




E502Burlington DanesHammersmith Campus






BibTex format

author = {Stagg, CJ and Bachtiar, V and O'Shea, J and Allman, C and Bosnell, RA and Kischka, U and Matthews, PM and Johansen-Berg, H},
doi = {brain/awr313},
journal = {BRAIN},
pages = {276--284},
title = {Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke},
url = {},
volume = {135},
year = {2011}

RIS format (EndNote, RefMan)

AB - Transcranial direct current stimulation, a form of non-invasive brain stimulation, is showing increasing promise as an adjuncttherapy in rehabilitation following stroke. However, although significant behavioural improvements have been reported inproof-of-principle studies, the underlying mechanisms are poorly understood. The rationale for transcranial direct current stimu-lation as therapy for stroke is that therapeutic stimulation paradigms increase activity in ipsilesional motor cortical areas, butthis has not previously been directly tested for conventional electrode placements. This study was performed to test directlywhether increases in ipsilesional cortical activation with transcranial direct current stimulation are associated with behaviouralimprovements in chronic stroke patients. Patients at least 6 months post-first stroke participated in a behavioural experiment(n= 13) or a functional magnetic resonance imaging experiment (n= 11), each investigating the effects of three stimulationconditions in separate sessions: anodal stimulation to the ipsilesional hemisphere; cathodal stimulation to the contralesionalhemisphere; and sham stimulation. Anodal (facilitatory) stimulation to the ipsilesional hemisphere led to significant improve-ments (5–10%) in response times with the affected hand in both experiments. This improvement was associated with anincrease in movement-related cortical activity in the stimulated primary motor cortex and functionally interconnected regions.Cathodal (inhibitory) stimulation to the contralesional hemisphere led to a functional improvement only when compared withsham stimulation. We show for the first time that the significant behavioural improvements produced by anodal stimulationto the ipsilesional hemisphere are associated with a functionally relevant increase in activity within the ipsilesional primary
AU - Stagg,CJ
AU - Bachtiar,V
AU - O'Shea,J
AU - Allman,C
AU - Bosnell,RA
AU - Kischka,U
AU - Matthews,PM
AU - Johansen-Berg,H
DO - brain/awr313
EP - 284
PY - 2011///
SN - 0006-8950
SP - 276
TI - Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke
UR -
UR -
UR -
VL - 135
ER -