Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@book{Matthews:2009:10.1007/978-1-60327-919-2_25,
author = {Matthews, PM},
doi = {10.1007/978-1-60327-919-2_25},
title = {Pharmacological applications of fMRI},
url = {http://dx.doi.org/10.1007/978-1-60327-919-2_25},
year = {2009}
}

RIS format (EndNote, RefMan)

TY  - BOOK
AB - Modern drug development presents new challenges by the unmet medical needs of chronic neurological and psychiatric disease. Imaging provides a potentially powerful tool for more efficiently translating pre-clinical and clinical studies and enhancing confidence in progression through early phase clinical development. Pharmacological MRI (phMRI) refers specifically to the applications of fMRI methods for direct or indirect measures of drug action. phMRI can be coupled to advanced structural methods to relate pharmacological effects and functional anatomy. Current and potential applications of phMRI to target stratification, patient validation, and pharmacodynamic studies are described. While great new opportunities could arise from extension of these methods as surrogate markers of clinical responses, this review highlights the substantial additional work that would need to be done to make this feasible. The review concludes that there is a strong rational for investment in phMRI for early phase clinical development, but that the short- to medium-term impact on late phase clinical development likely will be modest. © 2009 Humana Press.
AU - Matthews,PM
DO - 10.1007/978-1-60327-919-2_25
PY - 2009///
SN - 9781603279185
TI - Pharmacological applications of fMRI
UR - http://dx.doi.org/10.1007/978-1-60327-919-2_25
ER -