Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scott:2015:10.1186/s12974-015-0445-y,
author = {Scott, G and Hellyer, PJ and Ramlackhansingh, AF and Brooks, DJ and Matthews, PM and Sharp, DJ},
doi = {10.1186/s12974-015-0445-y},
journal = {Journal of Neuroinflammation},
title = {Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage},
url = {http://dx.doi.org/10.1186/s12974-015-0445-y},
volume = {12},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundTraumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo.FindingsUsing [11C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage.ConclusionsThese findings support a link between axonal damage and persistent inflammation after brain injury.
AU - Scott,G
AU - Hellyer,PJ
AU - Ramlackhansingh,AF
AU - Brooks,DJ
AU - Matthews,PM
AU - Sharp,DJ
DO - 10.1186/s12974-015-0445-y
PY - 2015///
SN - 1742-2094
TI - Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
T2 - Journal of Neuroinflammation
UR - http://dx.doi.org/10.1186/s12974-015-0445-y
UR - http://hdl.handle.net/10044/1/40260
VL - 12
ER -