Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department



+44 (0)20 7594 2855p.matthews




Ms Siobhan Dillon +44 (0)20 7594 2855




E502Burlington DanesHammersmith Campus






BibTex format

author = {Matthews, PM and Roncaroli, F and Waldman, A and Sormani, MP and De, Stefano N and Giovannoni, G and Reynolds, R},
doi = {10.1136/practneurol-2016-001381},
journal = {Practical Neurology},
pages = {279--287},
title = {A practical review of the neuropathology and neuroimaging of multiple sclerosis},
url = {},
volume = {16},
year = {2016}

RIS format (EndNote, RefMan)

AB - The variability in the severity and clinical course of multiple sclerosis (MS) has as its basis an extreme heterogeneity in the location, nature and extent of pathology in the brain and spinal cord. Understanding the underlying neuropathology and associated pathogenetic mechanisms of the disease helps to communicate the rationale for treatment and disease monitoring to patients. Neuroimaging is an important tool for this: it allows clinicians to relate neuropathological changes to clinical presentations and to monitor the course of their disease. Here, we review MS neuropathology and its imaging correlates to provide a practical guide for using MRI to assess disease severity and treatment responses. This provides a foundation for optimal management of patients based on the principle that they show 'no evidence of disease activity'.
AU - Matthews,PM
AU - Roncaroli,F
AU - Waldman,A
AU - Sormani,MP
AU - De,Stefano N
AU - Giovannoni,G
AU - Reynolds,R
DO - 10.1136/practneurol-2016-001381
EP - 287
PY - 2016///
SN - 1474-7766
SP - 279
TI - A practical review of the neuropathology and neuroimaging of multiple sclerosis
T2 - Practical Neurology
UR -
VL - 16
ER -