Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department



+44 (0)20 7594 2855p.matthews




Ms Siobhan Dillon +44 (0)20 7594 2855




E502Burlington DanesHammersmith Campus






BibTex format

author = {De, Guio F and Jouvent, E and Biessels, GJ and Black, SE and Brayne, C and Chen, C and Cordonnier, C and De, Leeuw FE and Dichgans, M and Doubal, F and Duering, M and Dufouil, C and Duzel, E and Fazekas, F and Hachinski, V and Ikram, MA and Linn, J and Matthews, PM and Mazoyer, B and Mok, V and Norrving, B and O'Brien, JT and Pantoni, L and Ropele, S and Sachdev, P and Schmidt, R and Seshadri, S and Smith, EE and Sposato, LA and Stephan, B and Swartz, RH and Tzourio, C and van, Buchem M and van, der Lugt A and van, Oostenbrugge R and Vernooij, MW and Viswanathan, A and Werring, D and Wollenweber, F and Wardlaw, JM and Chabriat, H},
doi = {10.1177/0271678X16647396},
journal = {Journal of Cerebral Blood Flow & Metabolism},
pages = {1319--1337},
title = {Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.},
url = {},
volume = {36},
year = {2016}

RIS format (EndNote, RefMan)

AB - Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
AU - De,Guio F
AU - Jouvent,E
AU - Biessels,GJ
AU - Black,SE
AU - Brayne,C
AU - Chen,C
AU - Cordonnier,C
AU - De,Leeuw FE
AU - Dichgans,M
AU - Doubal,F
AU - Duering,M
AU - Dufouil,C
AU - Duzel,E
AU - Fazekas,F
AU - Hachinski,V
AU - Ikram,MA
AU - Linn,J
AU - Matthews,PM
AU - Mazoyer,B
AU - Mok,V
AU - Norrving,B
AU - O'Brien,JT
AU - Pantoni,L
AU - Ropele,S
AU - Sachdev,P
AU - Schmidt,R
AU - Seshadri,S
AU - Smith,EE
AU - Sposato,LA
AU - Stephan,B
AU - Swartz,RH
AU - Tzourio,C
AU - van,Buchem M
AU - van,der Lugt A
AU - van,Oostenbrugge R
AU - Vernooij,MW
AU - Viswanathan,A
AU - Werring,D
AU - Wollenweber,F
AU - Wardlaw,JM
AU - Chabriat,H
DO - 10.1177/0271678X16647396
EP - 1337
PY - 2016///
SN - 0271-678X
SP - 1319
TI - Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.
T2 - Journal of Cerebral Blood Flow & Metabolism
UR -
UR -
VL - 36
ER -