Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Brain Sciences

Edmond and Lily Safra Chair. Head of Department



+44 (0)20 7594 2855p.matthews




Ms Siobhan Dillon +44 (0)20 7594 2855




E502Burlington DanesHammersmith Campus






BibTex format

author = {Suzuki, HS and Gao, HG and Bai, WB and Evangelou, EE and Glocker, BG and O'regan, DO and Elliott, PE and Matthews, PMM},
doi = {10.1371/journal.pone.0187600},
journal = {PLoS ONE},
title = {Abnormal brain white matter microstructure is associated withboth pre-hypertension and hypertension},
url = {},
volume = {12},
year = {2017}

RIS format (EndNote, RefMan)

AB - ObjectivesTo characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known neurological or psychiatric disease (62.3±7.4 yrs, 47.0% male) in UK Biobank.MethodsFor assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p<0.05 after Bonferroni correction).ResultsThe brain white matter intracellular volume fraction was significantly lower, and isotropic volume fraction was higher in hypertensive relative to non-hypertensive individuals (N = 1559, each). The white matter isotropic volume fraction also was higher in pre-hypertensive than in normotensive individuals (N = 694, each) in the right superior longitudinal fasciculus and the right superior thalamic radiation, where the lower intracellular volume fraction was observed in the hypertensives relative to the non-hypertensive group.SignificancePathological processes associated with chronically elevated blood pressure are associated with imaging differences suggesting chronic alterations of white matter axonal structure that may affect cognitive functions even with pre-hypertension.
AU - Suzuki,HS
AU - Gao,HG
AU - Bai,WB
AU - Evangelou,EE
AU - Glocker,BG
AU - O'regan,DO
AU - Elliott,PE
AU - Matthews,PMM
DO - 10.1371/journal.pone.0187600
PY - 2017///
SN - 1932-6203
TI - Abnormal brain white matter microstructure is associated withboth pre-hypertension and hypertension
UR -
UR -
VL - 12
ER -