Imperial College London

Professor Paul M. Matthews

Faculty of MedicineDepartment of Medicine

Edmond and Lily Safra Chair and Head of Brain Sciences
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ntusi:2018:10.1016/j.hjc.2018.01.008,
author = {Ntusi, NAB and Francis, JM and Gumedze, F and Karvounis, H and Matthews, PM and Wordsworth, PB and Neubauer, S and Karamitsos, TD},
doi = {10.1016/j.hjc.2018.01.008},
journal = {Hellenic Journal of Cardiology},
title = {Cardiovascular magnetic resonance characterization of myocardial and vascular function in rheumatoid arthritis patients},
url = {http://dx.doi.org/10.1016/j.hjc.2018.01.008},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: Rheumatoid arthritis (RA) is a multisystem, autoimmune disorder and confers one of the strongest risks for cardiovascular disease (CVD) morbidity and mortality. OBJECTIVE: To assess myocardial function and vascular stiffness in RA patients with and without cardiovascular risk factors (CVRFs) using cardiovascular magnetic resonance (CMR). METHODS: Twenty-three RA patients with no CVRFs (17 female, mean age 52 ± 13 years), 46 RA patients with CVRFs (32 female, mean age 53 ± 12), 50 normal controls (32 female, mean age 50 ± 11 years), and 13 controls with CVRFs (7 female, mean age 55 ± 7 years), underwent CMR at 1.5 Tesla, including evaluation of left ventricular (LV) ejection fraction, strain, and vascular elasticity (aortic distensibility [AD] and pulse wave velocity [PWV]). Disease activity and duration were recorded for each patient. Subjects with known symptomatic CVD were excluded. RESULTS: LV volumes, mass, and ejection fraction were similar in the four groups. RA patients with CVRFs showed the greatest abnormality in mid short-axis circumferential systolic strain, peak diastolic strain rate, and vascular indices. RA patients without CVRFs showed a similar degree of vascular dysfunction and deformational abnormality as controls with CVRFs. AD and total PWV correlated with myocardial strain and RA disease activity. On multivariate regression analysis, strain was related to age, RA disease activity, AD, and PWV. CONCLUSION: CMR demonstrates impaired myocardial deformation and vascular function in asymptomatic RA patients, worse in those with CVRFs. Subclinical cardiovascular abnormalities are frequent and appear to be incremental to those due to traditional CVRFs and likely contribute to the excess CVD in RA.
AU - Ntusi,NAB
AU - Francis,JM
AU - Gumedze,F
AU - Karvounis,H
AU - Matthews,PM
AU - Wordsworth,PB
AU - Neubauer,S
AU - Karamitsos,TD
DO - 10.1016/j.hjc.2018.01.008
PY - 2018///
SN - 1109-9666
TI - Cardiovascular magnetic resonance characterization of myocardial and vascular function in rheumatoid arthritis patients
T2 - Hellenic Journal of Cardiology
UR - http://dx.doi.org/10.1016/j.hjc.2018.01.008
UR - https://www.ncbi.nlm.nih.gov/pubmed/29369795
UR - http://hdl.handle.net/10044/1/57969
ER -