Professor Paul M. Matthews

Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Matthews PMet al., 2003, Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy, NEUROIMAGE, Vol: 18, Pages: 423-438, ISSN: 1053-8119

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• Citations: 264

Parry A, Corkill R, Blamire AM, Palace J, Narayanan S, Arnold D, Styles P, Matthews PMet al., 2003, Beta-interferon treatment does not always slow the progression of axonal injury in multiple sclerosis, JOURNAL OF NEUROLOGY, Vol: 250, Pages: 171-178, ISSN: 0340-5354

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• Citations: 64

Devlin JT, Matthews PM, Rushworth MFS, 2003, Semantic processing in the left inferior prefrontal cortex: A combined functional magnetic resonance imaging and transcranial magnetic stimulation study, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 15, Pages: 71-84, ISSN: 0898-929X

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• Citations: 426

Reddy H, Narayanan S, Woolrich M, Mitsumori T, Lapierre Y, Arnold DL, Matthews PMet al., 2002, Functional brain reorganization for hand movement in patients with multiple sclerosis: Defining distinct effects of injury and disability, Brain, Vol: 125, Pages: 2646-2657, ISSN: 0006-8950

Previous work has demonstrated potentially adaptive cortical plasticity that increases with brain injury in patients with multiple sclerosis. However, animal studies showing use-dependent changes in motor cortex organization suggest that functional changes also may occur in response to disability. We therefore wished to test whether brain injury and disability lead to distinguishable patterns of activation with hand movement in patients with multiple sclerosis. By employing a passive as well as an active movement task, we also wished to test whether these changes were independent of voluntary recruitment and thus mor likely to reflect true functional reorganization. Fourteen patients [Extended Disability Status Score (EDSS) 0-7.5] with relapsing- remitting multiple sclerosis were selected on the basis of pathology load and hand functional impairment for three study groups: group 1, low diffuse central brain injury (DCBI) as assessed from relative N-acetylaspartate concentration (a marker of axonal integrity) and normal hand function (n = 6); group 2, greater DCBI and normal hand function (n = 4); and group 3, greater DCBI and impaired hand function (n = 4). Functional MRI (fMRI) was used to map brain activation with a four-finger and both one-finger passive and active flexion-extension movement tasks for the three groups. Considering all the patients, we found increased activity in ipsilateral premotor and ipsilateral motor cortex (IMC) and in the ipsilateral inferior parietal lobule with increasing global disability (as assessed from the EDSS score). These changes appear to define true functional reorganization, as fMRI activations in IMC (r = 0.87, P < 0.001) and in the contralateral motor cortex (r = 0.67, P < 0.007) were highly correlated between active and passive single finger movements. We attempted to disambiguate any distinct effects of disability and brain injury by direct contrasts between patients differing predominantly in one or the other. To mak

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• Citations: 163

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2002, Correlation between motor improvements and altered fMRI activity after rehabilitative therapy, Brain, Vol: 125, Pages: 2731-2742, ISSN: 0006-8950

Motor rehabilitation therapy is commonly employed after strokes, but outcomes are variable and there is little specific information about the changes in brain activity that are associated with improved function. We performed serial functional MRI (fMRI) on a group of seven patients receiving a form of rehabilitation therapy after stroke in order to characterize functional changes in the brain that correlate with behavioural improvements. Patients were scanned while performing a hand flexion-extension movement twice before and twice after a two-week home-based therapy programme combining restraint of the unaffected limb with progressive exercises for the affected limb. As expected, the extent of improvement in hand function after therapy varied between patients. Therapy-related improvements in hand function correlated with increases in fMRI activity in the premotor cortex and secondary somatosensory cortex contralateral to the affected hand, and in superior posterior regions of the cerebellar hemispheres bilaterally (Crus I and lobule VI). fMRI offers a promising, objective approach for specifically identifying changes in brain activity potentially responsible for rehabilitation-mediated recovery of function after stroke. Our results suggest that activity changes in sensorimotor regions are associated with successful motor rehabilitation.

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• Citations: 494

Reddy H, Narayanan S, Woolrich M, Mitsumori T, Lapierre Y, Arnold DL, Matthews PMet al., 2002, Functional brain reorganization for hand movement in patients with multiple sclerosis: defining distinct effects of injury and disability, BRAIN, Vol: 125, Pages: 2646-2657, ISSN: 0006-8950

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• Citations: 136

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PMet al., 2002, Correlation between motor improvements and altered fMRI activity after rehabilitative therapy, BRAIN, Vol: 125, Pages: 2731-2742, ISSN: 0006-8950

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• Citations: 429

Robinson GV, Miall RC, Matthews PM, Jones EM, Winter J, Stein J, Stradling JR, Davies RJOet al., 2002, Brain fMRI activation and evoked potentials during visual stimulation and visuo-motor tracking in normal subjects before and after sleep deprivation, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, ISSN: 0040-6376

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Smith KA, Ploghaus A, Cowen PJ, McCleery JM, Goodwin GM, Smith S, Tracey I, Matthews PMet al., 2002, Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression - Functional magnetic resonance imaging study, BRITISH JOURNAL OF PSYCHIATRY, Vol: 181, Pages: 411-415, ISSN: 0007-1250

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• Citations: 49

Cifelli A, Arridge M, Jezzard P, Esiri MM, Palace J, Matthews PMet al., 2002, Thalamic neurodegeneration in multiple sclerosis, ANNALS OF NEUROLOGY, Vol: 52, Pages: 650-653, ISSN: 0364-5134

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• Citations: 379

Fu SM, Chen YP, Smith S, Iversen S, Matthews PMet al., 2002, Effects of word form on brain processing of written Chinese, NEUROIMAGE, Vol: 17, Pages: 1538-1548, ISSN: 1053-8119

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• Citations: 95

Johansen-Berg H, Rushworth MFS, Bogdanovic MD, Kischka U, Wimalaratna S, Matthews PMet al., 2002, The role of ipsilateral premotor cortex in hand movement after stroke, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 14518-14523, ISSN: 0027-8424

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• Citations: 589

Chen YP, Fu SM, Iversen SD, Smith SM, Matthews PMet al., 2002, Testing for dual brain processing routes in reading: A direct contrast of chinese character and pinyin reading using fMRI, JOURNAL OF COGNITIVE NEUROSCIENCE, Vol: 14, Pages: 1088-1098, ISSN: 0898-929X

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• Citations: 138

Andrews T, 2002, Activity in the Fusiform Gyrus Predicts Conscious Perception of Rubin's Vase–Face Illusion, NeuroImage, Vol: 17, Pages: 890-901, ISSN: 1053-8119

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Andrews TJ, Schluppeck D, Homfray D, Matthews P, Blakemore Cet al., 2002, Activity in the fusiform gyrus predicts conscious perception of Rubin's vase-face illusion, NEUROIMAGE, Vol: 17, Pages: 890-901, ISSN: 1053-8119

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• Citations: 96

Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PMet al., 2002, White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis, JOURNAL OF NEUROLOGY, Vol: 249, Pages: 1279-1286, ISSN: 0340-5354

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• Citations: 75

Smith SM, Zhang YY, Jenkinson M, Chen J, Matthews PM, Federico A, De Stefano Net al., 2002, Accurate, robust, and automated longitudinal and cross-sectional brain change analysis, NEUROIMAGE, Vol: 17, Pages: 479-489, ISSN: 1053-8119

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• Citations: 1610

Cifelli A, Wylezinska M, Esiri M, Palace J, Matthews Pet al., 2002, Grey matter neuronal loss in multiple sclerosis, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 226-226, ISSN: 0022-3050

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Parry A, Corkill R, Blamire A, Palace J, Narayanan S, Arnold D, Styles P, Matthews PMet al., 2002, β-interferon treatment does not immediately slow the progression of axonal injury in multiple sclerosis, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 73, Pages: 214-214, ISSN: 0022-3050

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Floyer A, Matthews PM, 2002, The clinical potential of MR at 3T: Developing an integrated clinical-pathological view of brain injury, Clinical MRI, Vol: 12, Pages: 31-34, ISSN: 0961-9275

Magnetic resonance imaging techniques are increasingly being applied to clinical situations, and the use of higher field strength imaging systems promises to increase their utility and expand the range of applications still further. Although high field strengths present a number of methodological challenges, specialised techniques are being developed to overcome these issues. In the future MRI is likely to continue to prove invaluable in achieving a greater understanding of disease and recovery processes in the brain.

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Cifelli A, Matthews PM, 2002, Cerebral plasticity in multiple sclerosis: insights from fMRI, MULTIPLE SCLEROSIS, Vol: 8, Pages: 193-199, ISSN: 1352-4585

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• Citations: 51

Matthews PM, 2002, White matter change and stroke risk, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 72, Pages: 564-565, ISSN: 0022-3050

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Kushner MJ, 2002, "Sick" MRI syndrome., J Neurol Neurosurg Psychiatry, Vol: 72, ISSN: 0022-3050

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Arnold DL, Matthews PM, 2002, MRI in the diagnosis and management of multiple sclerosis, NEUROLOGY, Vol: 58, Pages: S23-S31, ISSN: 0028-3878

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• Citations: 55

Arnold DL, Matthews PM, 2002, MRI in the diagnosis and management of multiple sclerosis, Neurology, Vol: 58, ISSN: 0028-3878

MRI techniques, including conventional T2-weighted and gadolinium (Gd)-enhanced T1-weighted images, have provided important insights into the pathophysiology of MS. Although the correlation of MRI measures with clinical disability and outcome continues to be investigated, MRI measures are routinely used both in clinical practice and in MS research. In addition to its use as a diagnostic tool, MRI is used as a surrogate marker to monitor disease progression and response to therapy. A variety of MRI measures are used in drug development studies and have aided our understanding of the potential benefits and possible mechanisms of action of drug therapies. Advances in MRI techniques may further elucidate the pathology of MS, thus providing opportunities for new treatment strategies.

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• Citations: 78

De Stefano N, Matthews PM, Filippi M, Iannucci G, Ghezzi A, Montanari E, Bartolozzi ML, Guidi L, Federico A, Smith Set al., 2002, Evidence of early cortical gray matter atrophy in patients with relapsing-remitting and primary progressive multiple sclerosis, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A503-A503, ISSN: 0028-3878

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Freedman MS, Atkins HL, Arnold D, Bowman MJet al., 2002, Reduction in gadolinium-enhancing lesions and clinical stability in multiple sclerosis patients receiving a combination of cyclophosphamide and filgrastim (G-CSF) in preparation for stem cell mobilization, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A457-A457, ISSN: 0028-3878

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Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PMet al., 2002, Imaging attentional modulation of pain in the periaqueductal gray in humans, JOURNAL OF NEUROSCIENCE, Vol: 22, Pages: 2748-2752, ISSN: 0270-6474

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• Citations: 405

Rocca MA, Matthews PM, Caputo D, Ghezzi A, Falini A, Scotti G, Comi G, Filippi Met al., 2002, Evidence for widespread movement-associated functional MRI changes in patients with PPMS, NEUROLOGY, Vol: 58, Pages: 866-872, ISSN: 0028-3878

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• Citations: 123

Hewett D, Samuelsson L, Polding J, Enlund F, Smart D, Cantone K, See CG, Chadha S, Inerot A, Enerback C, Montgomery D, Christodolou C, Robinson P, Matthews P, Plumpton M, Dykes C, Wahlstrom J, Swanbeck G, Martinsson T, Roses A, Riley J, Purvis Iet al., 2002, Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map, GENOMICS, Vol: 79, Pages: 305-314, ISSN: 0888-7543

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• Citations: 80