Imperial College London
Alternate

Professor Paul M. Matthews

Faculty of Medicine, Department of Brain Sciences

Edmond and Lily Safra Chair, Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

756 results found

Lee MA, Blamire AM, Pendlebury S, Ho KH, Mills KR, Styles P, Palace J, Matthews PMet al., 2000, Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis, ARCHIVES OF NEUROLOGY, Vol: 57, Pages: 65-70, ISSN: 0003-9942

Journal article

Smith SM, Matthews PM, 1999, Structural brain change analysis, NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Lee MA, Smith S, Palace J, Matthews PMet al., 1999, Application of lesion probability maps to analysis of the spatio-temporal evolution of the T2-hyperintense lesions of multiple sclerosis (MS), NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Johansen-Berg H, Pendlebury ST, Matthews PM, 1999, Interactions between rate, complexity and handedness in a finger tapping task using the dominant and non-dominant hand, NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JNPet al., 1999, FMRI distinguishes patterns of brain activation specific to pain and its anticipation, NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Reddy H, Lee MA, Matthews PM, 1999, Characterization of simple hand movement tasks for use in clinical fMRI studies, NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Ploghaus A, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JNP, Tracey Iet al., 1999, Unexpected and anticipated pain are associated with distinct brain activations, NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Adcock JE, Calvert GA, Matthews PM, 1999, The determination of language dominance using verbal fluency tasks of short duration at high (3T) field, NeuroImage, Vol: 9, ISSN: 1053-8119

Journal article

Matthews PM, 1999, Axonal loss and demyelation in multiple sclerosis, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 67, Pages: 708-709, ISSN: 0022-3050

Journal article

Griffin JL, Rae C, Radda GK, Matthews PMet al., 1999, Lactate-induced inhibition of glucose catabolism in guinea pig cortical brain slices, NEUROCHEMISTRY INTERNATIONAL, Vol: 35, Pages: 405-409, ISSN: 0197-0186

Journal article

De Stefano N, Narayanan S, Matthews PM, Francis GS, Antel JP, Arnold DLet al., 1999, <i>In vivo</i> evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis, BRAIN, Vol: 122, Pages: 1933-1939, ISSN: 0006-8950

Journal article

Morten KJ, Beattie P, Brown GK, Matthews PMet al., 1999, Dichloroacetate stabilizes the mutant E1α subunit in pyruvate dehydrogenase deficiency, NEUROLOGY, Vol: 53, Pages: 612-616, ISSN: 0028-3878

Journal article

Griffin JL, Rae C, Radda GK, Matthews PMet al., 1999, Delayed labelling of brain glutamate after an intra-arterial [<SUP>13</SUP>C]glucose bolus:: evidence for aerobic metabolism of guinea pig brain glycogen store, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Vol: 1450, Pages: 297-307, ISSN: 0167-4889

Journal article

Lee MA, Smith S, Palace J, Narayanan S, Silver N, Minicucci L, Filippi M, Miller DH, Arnold DL, Matthews PMet al., 1999, Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: evidence for distinct mechanisms of lesion genesis?, Brain : a journal of neurology, Vol: 122, ISSN: 0006-8950

It is generally believed that most T2-weighted (T2) lesions in the central white matter of patients with multiple sclerosis begin with a variable period of T1-weighted (T1) gadolinium (Gd) enhancement and that T1 Gd-enhancing and T2 lesions represent stages of a single pathological process. Lesion probability maps can be used to test this hypothesis by providing a quantitative description of the spatial distribution of these two types of lesions across a patient population. The simplest prediction of this hypothesis would be that the spatial distributions of T1 Gd-enhancing and T2 lesions are identical. We generated T1 Gd-enhancing and T2 lesion probability maps from 19 patients with relapsing-remitting multiple sclerosis. There was a significantly higher probability (P = 0.001) for T2 lesions to be found in the central relative to the peripheral white matter (risk ratio 4.5), although the relative distribution of T1 Gd-enhancing lesions was not significantly different (P = 0.7) between central and peripheral white matter regions (risk ratio 0.6). Longitudinal data on the same population were used to demonstrate a similar distribution asymmetry between new T1 Gd-enhancing and new T2 lesions that developed over the course of 1 year. Alternative hypotheses to explain this observation were tested. We found no spatial difference in the likelihood of development of persistent T2 lesions following T1 Gd enhancement. The relative distribution of T1 Gd-enhancing lesions was shown to be independent of the dose of Gd contrast agent and the frequency of scanning. Our findings suggest that a proportion of the periventricular T2 lesion volume may arise from mechanisms other than those associated with early breakdown of the blood-brain barrier leading to T1 Gd enhancement.

Journal article

Lee MA, Smith S, Palace J, Narayanan S, Silver N, Minicucci L, Filippi M, Miller DH, Arnold DL, Matthews PMet al., 1999, Spatial mapping of T<sub>2</sub> and gadolinium-enhancing T<sub>1</sub> lesion volumes in multiple sclerosis:: evidence for distinct mechanisms of lesion genesis?, BRAIN, Vol: 122, Pages: 1261-1270, ISSN: 0006-8950

Journal article

Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JNPet al., 1999, Dissociating pain from its anticipation in the human brain, SCIENCE, Vol: 284, Pages: 1979-1981, ISSN: 0036-8075

Journal article

Matthews PM, Clare S, Adcock J, 1999, Functional magnetic resonance imaging: Clinical applications and potential, JOURNAL OF INHERITED METABOLIC DISEASE, Vol: 22, Pages: 337-352, ISSN: 0141-8955

Journal article

Pendlebury ST, Blamire AM, Lee MA, Styles P, Matthews PMet al., 1999, Axonal injury in the internal capsule correlates with motor impairment after stroke, STROKE, Vol: 30, Pages: 956-962, ISSN: 0039-2499

Journal article

Nagy Z, Esiri MM, LeGris M, Matthews PMet al., 1999, Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology, ACTA NEUROPATHOLOGICA, Vol: 97, Pages: 346-354, ISSN: 0001-6322

Journal article

Pendlebury ST, Blamire AM, Lee MA, Styles P, Matthews Pet al., 1999, Axonal injury in the internal capsule correlates with motor impairment after stroke, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 237-237, ISSN: 0039-2499

Conference paper

Griffin JL, Rae C, Dixon RM, Radda GK, Matthews PMet al., 1998, Excitatory amino acid synthesis in hypoxic brain slices: Does alanine act as a substrate for glutamate production in hypoxia?, JOURNAL OF NEUROCHEMISTRY, Vol: 71, Pages: 2477-2486, ISSN: 0022-3042

Journal article

Lee MA, Smith S, Palace J, Matthews PMet al., 1998, Defining multiple sclerosis disease activity using MRI T<sub>2</sub>-weighted difference imaging, BRAIN, Vol: 121, Pages: 2095-2102, ISSN: 0006-8950

Journal article

Morten KJ, Caky M, Matthews PM, 1998, Stabilization of the pyruvate dehydrogenase E1α subunit by dichloroacetate, NEUROLOGY, Vol: 51, Pages: 1331-1335, ISSN: 0028-3878

Journal article

Morten KJ, Caky M, Matthews PM, 1998, Mechanisms of expression of pyruvate dehydrogenase deficiency caused by an E1α subunit mutation, NEUROLOGY, Vol: 51, Pages: 1324-1330, ISSN: 0028-3878

Journal article

De Stefano N, Narayanan S, Matthews PM, Francis GS, Antel JP, Arnold DLet al., 1998, Transient axonal dysfunction contralateral to large brain hemispheric demyelinating lesions of the type seen in multiple sclerosis, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 465-465, ISSN: 0364-5134

Conference paper

De Stefano N, Matthews PM, Fu LQ, Narayanan S, Stanley J, Francis GS, Antel JP, Arnold DLet al., 1998, Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis - Results of a longitudinal magnetic resonance spectroscopy study, BRAIN, Vol: 121, Pages: 1469-1477, ISSN: 0006-8950

Journal article

Arnold DL, Wolinsky JS, Matthews PM, Falini Aet al., 1998, The use of magnetic resonance spectroscopy in the evaluation of the natural history of multiple sclerosis, Meeting on the Magnetic Resonance Techniques in Multiple Sclerosis, Publisher: BMJ PUBLISHING GROUP, Pages: S94-S101, ISSN: 0022-3050

Conference paper

Morten K, Caky M, Matthews PM, 1998, Molecular mechanisms of expression of pyruvate dehydrogenase deficiency associated with the E1α subunit, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A118-A118, ISSN: 0028-3878

Conference paper

Calvert G, Brammer MJ, Morris RG, Williams SC, Allinson J, Matthews PMet al., 1998, Demonstration that right hemispheric activation dominates during language tasks after partial recovery from acquired expressive aphasia using functional magnetic resonance imaging, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A328-A328, ISSN: 0028-3878

Conference paper

De Stefano N, Federico A, Marzia M, Narayanan S, Dotti MT, Dal Pozzo G, Matthews PM, Arnold DLet al., 1998, Axonal damage is a proximate cause of central nervous system impairment in patients with white matter disorders, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A108-A108, ISSN: 0028-3878

Conference paper

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