Publications
756 results found
Yang X, Nie L, Matthews PM, et al., 2015, The critical regularization value: incorporating spatial smoothness to enhance signal detection in highly noisy fMRI data, 7th Annual International IEEE EMBS Conference on Neural Engineering (NER), Publisher: IEEE, Pages: 1076-1079, ISSN: 1948-3546
Matthews PM, 2015, Clinical Applications of fMRI, FMRI: FROM NUCLEAR SPINS TO BRAIN FUNCTIONS, Editors: Uludag, Ugurbil, Berliner, Publisher: SPRINGER, Pages: 611-632, ISBN: 978-1-4899-7590-4
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- Citations: 1
Douaud G, Groves AR, Tamnes CK, et al., 2014, A common brain network links development, aging, and vulnerability to disease, Proceedings of the National Academy of Sciences of the United States of America, Vol: 111, Pages: 17648-17653, ISSN: 0027-8424
Several theories link processes of development and aging in humans. In neuroscience, one model posits for instance that healthy age-related brain degeneration mirrors development, with the areas of the brain thought to develop later also degenerating earlier. However, intrinsic evidence for such a link between healthy aging and development in brain structure remains elusive. Here, we show that a data-driven analysis of brain structural variation across 484 healthy participants (8–85 y) reveals a largely—but not only—transmodal network whose lifespan pattern of age-related change intrinsically supports this model of mirroring development and aging. We further demonstrate that this network of brain regions, which develops relatively late during adolescence and shows accelerated degeneration in old age compared with the rest of the brain, characterizes areas of heightened vulnerability to unhealthy developmental and aging processes, as exemplified by schizophrenia and Alzheimer’s disease, respectively. Specifically, this network, while derived solely from healthy subjects, spatially recapitulates the pattern of brain abnormalities observed in both schizophrenia and Alzheimer’s disease. This network is further associated in our large-scale healthy population with intellectual ability and episodic memory, whose impairment contributes to key symptoms of schizophrenia and Alzheimer’s disease. Taken together, our results suggest that the common spatial pattern of abnormalities observed in these two disorders, which emerge at opposite ends of the life spectrum, might be influenced by the timing of their separate and distinct pathological processes in disrupting healthy cerebral development and aging, respectively.
Ricotti V, Evans RB, Sinclair CDJ, et al., 2014, Upper limb muscle MRI fat-water quantification and clinical functional correlation in non-ambulant Duchenne muscular dystrophy, 19th International Congress of the World-Muscle-Society, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 839-839, ISSN: 0960-8966
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- Citations: 2
Bishop CA, Ricotti V, Sinclair CDJ, et al., 2014, Semi-automated analysis of diaphragmatic motion during deep breathing using dynamic MRI in both healthy controls and non-ambulant Duchenne muscular dystrophy, 19th International Congress of the World-Muscle-Society, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 852-853, ISSN: 0960-8966
Scott G, Sharp DJ, Ramlackhansingh A, et al., 2014, NEUROINFLAMMATION AND AMYLOID PATHOLOGY AFTER TBI, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 85, ISSN: 0022-3050
Linortner P, Jehna M, Johansen-Berg H, et al., 2014, Aging associated changes in the motor control of ankle movements in the brain, NEUROBIOLOGY OF AGING, Vol: 35, Pages: 2222-2229, ISSN: 0197-4580
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- Citations: 7
Ntusi NAB, Sever E, Lockey J, et al., 2014, Myocardial perfusion reserve is associated with impaired strain and higher disease activity in rheumatoid arthritis: cardiovascular magnetic resonance study, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 796-796, ISSN: 0195-668X
Colasanti A, Guo Q, Muhlert N, et al., 2014, In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with <SUP>18</SUP>F-PBR111 PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 1112-1118, ISSN: 0161-5505
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- Citations: 78
Battaglini M, Rossi F, Grove RA, et al., 2014, Automated Identification of Brain New Lesions in Multiple Sclerosis Using Subtraction Images, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 39, Pages: 1543-1549, ISSN: 1053-1807
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- Citations: 37
Comninos AN, Anastasovska J, Sahuri-Arisoylu M, et al., 2014, Kisspeptin Inhibits Neuronal Activity in the Amygdala of Male Mice, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Russo E, Khan S, Brown AP, et al., 2014, CORRELATION OF FDG PET SCANNING WITH ENDOSCOPIC FINDINGS IN PATIENTS WITH CROHN'S DISEASE, GUT, Vol: 63, Pages: A74-A74, ISSN: 0017-5749
Khamis RY, Woollard KJ, Hyde GD, et al., 2014, DEVELOPMENT OF WHOLE BODY AND INTRAVASCULAR NEAR-INFRARED OPTICAL MOLECULAR IMAGING OF MARKERS OF PLAQUE VULNERABLITY IN ATHEROSCLEROSIS, Annual Conference of the British-Cardiovascular-Society
Colasanti A, Guo Q, Giannetti P, et al., 2014, TSPO-targeted PET Imaging Suggests Increased Microglia Activation in Multiple Sclerosis Hippocampus is Correlated to Depressive Symptomatology, 69th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry, Publisher: ELSEVIER SCIENCE INC, Pages: 94S-95S, ISSN: 0006-3223
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- Citations: 1
Russo E, Dikaios N, Makanyanga JC, et al., 2014, The Use of Maria Score and Dynamic Contrast Enhancement MRI Endpoints in Patients With Endoscopic Evidence of Active Crohn's Disease, 55th Annual Meeting of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) / Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S430-S430, ISSN: 0016-5085
Matthews PM, 2014, An engaging tour through Oxford's medical history, LANCET, Vol: 383, Pages: 1201-1202, ISSN: 0140-6736
Khamis R, Woollard K, Hyde G, et al., 2014, NEAR-INFRARED FLUORESCENCE (NIRF) WHOLE BODY AND INTRA-ARTERIAL MOLECULAR IMAGING OF OXIDIZED LDL IN EXPERIMENTAL ATHEROSCLEROSIS, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A2150-A2150, ISSN: 0735-1097
Matthews PM, 2014, The virtues of adaptability, MULTIPLE SCLEROSIS JOURNAL, Vol: 20, Pages: 394-396, ISSN: 1352-4585
Newbould RD, Nicholas R, Thomas CL, et al., 2014, Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis, NeuroImage: Clinical, Vol: 4, Pages: 641-648, ISSN: 2213-1582
BackgroundMultiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration.ObjectiveTo determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI.Materials and methodsForty MS patients were recruited from out-patient clinics into two groups stratified by age but with similar clinical disease duration as well as thirteen controls age-matched to the older MS group. Images were segmented by automated programs and blinded readers into normal appearing white matter (NAWM), normal appearing gray matter (NAGM), and white matter lesions (WMLs) and gray matter lesions (GMLs) in the MS groups. WML and GML were delineated on T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) and T1 weighted MRI volumes. Mean magnetization transfer ratio (MTR), region volume, as well as MTR histogram skew and kurtosis were calculated for each region.ResultsAll MTR measures in NAGM and MTR histogram metrics in NAWM differed between MS subjects and controls, as expected and previously reported by several studies, but not between MS groups. However, MTR measures in the WML did significantly differ between the MS groups, in spite of no significant differences in lesion counts and volumes.ConclusionsDespite matching for clinical disease duration and recording no significant WML volume difference, we demonstrated strong MTR differences in WMLs between younger and older MS patients. These data suggest that aging-related processes modify the tissue response to inflammatory injury and its clinical outcome correlates in MS.
Ntusi NAB, Piechnik SK, Francis JM, et al., 2014, Subclinical myocardial inflammation and diffuse fibrosis are common in systemic sclerosis - a clinical study using myocardial T1-mapping and extracellular volume quantification, Journal of Cardiovascular Magnetic Resonance, Vol: 16, ISSN: 1097-6647
Background:Systemic sclerosis (SSc) is characterised by multi-organ tissue fibrosis including the myocardium. Diffuse myocardial fibrosis can be detected non-invasively by T1 and extracellular volume (ECV) quantification, while focal myocardial inflammation and fibrosis may be detected by T2-weighted and late gadolinium enhancement (LGE), respectively, using cardiovascular magnetic resonance (CMR). We hypothesised that multiparametric CMR can detect subclinical myocardial involvement in patients with SSc.Methods:19 SSc patients (18 female, mean age 55 ± 10 years) and 20 controls (19 female, mean age 56 ± 8 years) without overt cardiovascular disease underwent CMR at 1.5T, including cine, tagging, T1-mapping, T2-weighted, LGE imaging and ECV quantification.Results:Focal fibrosis on LGE was found in 10 SSc patients (53%) but none of controls. SSc patients also had areas of myocardial oedema on T2-weighted imaging (median 13 vs. 0% in controls). SSc patients had significantly higher native myocardial T1 values (1007 ± 29 vs. 958 ± 20 ms, p < 0.001), larger areas of myocardial involvement by native T1 >990 ms (median 52 vs. 3% in controls) and expansion of ECV (35.4 ± 4.8 vs. 27.6 ± 2.5%, p < 0.001), likely representing a combination of low-grade inflammation and diffuse myocardial fibrosis. Regardless of any regional fibrosis, native T1 and ECV were significantly elevated in SSc and correlated with disease activity and severity. Although biventricular size and global function were preserved, there was impairment in the peak systolic circumferential strain (-16.8 ± 1.6 vs. -18.6 ± 1.0, p < 0.001) and peak diastolic strain rate (83 ± 26 vs. 114 ± 16 s-1, p < 0.001) in SSc, which inversely correlated with diffuse myocardial fibrosis indices.Conclusions:Cardiac involvement is common in SSc even in the absence of cardiac symptoms, and includes chronic myocardial inflammation as well as foca
Russo E, Khan S, Brown A, et al., 2014, Correlation of FDG PET scanning with clinical and laboratory markers of activity in patients with Crohn's disease, JOURNAL OF CROHNS & COLITIS, Vol: 8, Pages: S167-S168, ISSN: 1873-9946
Matthews PM, Geraghty OC, 2014, Understanding the pharmacology of stroke and multiple sclerosis through imaging, CURRENT OPINION IN PHARMACOLOGY, Vol: 14, Pages: 34-41, ISSN: 1471-4892
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- Citations: 1
Ntusi NA, Piechnik SK, Francis JM, et al., 2014, Systemic sclerosis: detection of early subclinical diffuse myocardial fibrosis and impaired left ventricular strain by cardiovascular magnetic resonance, Journal of Cardiovascular Magnetic Resonance, Vol: 16, ISSN: 1097-6647
Tawakol A, Singh P, Rudd JHF, et al., 2014, Effect of Treatment for 12 Weeks With Rilapladib, a Lipoprotein-Associated Phospholipase A<sub>2</sub> Inhibitor, on Arterial Inflammation as Assessed With <SUP>18</SUP>F-Fluorodeoxyglucose-Positron Emission Tomography Imaging, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: 86-88, ISSN: 0735-1097
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- Citations: 64
Owen DR, Guo Q, Kalk NJ, et al., 2014, Eratum: Determination of [ 11 C]PBR28 binding potential in vivo: A first human TSPO blocking study (Journal of Cerebral Blood Flow and Metabolism (2014) 34 (1256)), Journal of Cerebral Blood Flow and Metabolism, Vol: 34, ISSN: 0271-678X
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- Citations: 3
Matthews PM, Edison P, Geraghty OC, et al., 2014, The emerging agenda of stratified medicine in neurology, NATURE REVIEWS NEUROLOGY, Vol: 10, Pages: 15-26, ISSN: 1759-4758
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- Citations: 23
Harvey NC, Matthews P, Collins R, et al., 2013, Osteoporosis epidemiology in UK Biobank: a unique opportunity for international researchers, OSTEOPOROSIS INTERNATIONAL, Vol: 24, Pages: 2903-2905, ISSN: 0937-941X
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- Citations: 20
Zarei M, Beckmann CF, Binnewijzend MAA, et al., 2013, Functional segmentation of the hippocampus in the healthy human brain and in Alzheimer's disease (vol 66, pg 28, 2013), NEUROIMAGE, Vol: 83, Pages: 1109-1109, ISSN: 1053-8119
Wu C, Zhu J, Baeslack J, et al., 2013, Longitudinal Positron Emission Tomography Imaging for Monitoring Myelin Repair in the Spinal Cord, ANNALS OF NEUROLOGY, Vol: 74, Pages: 688-698, ISSN: 0364-5134
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- Citations: 38
Colasanti A, Owen DR, Grozeva D, et al., 2013, Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO), PSYCHONEUROENDOCRINOLOGY, Vol: 38, Pages: 2826-2829, ISSN: 0306-4530
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- Citations: 41
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