Imperial College London
Alternate

Professor Paul M. Matthews

Faculty of Medicine, Department of Brain Sciences

Edmond and Lily Safra Chair, Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 2855p.matthews

 
 
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Assistant

 

Ms Siobhan Dillon +44 (0)20 7594 2855

 
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Location

 

E502Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Evangelou:2019:10.1038/s41562-019-0653-z,
author = {Evangelou, E and Gao, H and Blakeley, P and Pazoki, R and Suzuki, H and Elliott, J and Karaman, I and Jarvelin, MR and Tzoulaki, I and Bell, JD and Matthews, PM and Elliott, P},
doi = {10.1038/s41562-019-0653-z},
journal = {Nature Human Behaviour},
pages = {950--961},
title = {New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders},
url = {http://dx.doi.org/10.1038/s41562-019-0653-z},
volume = {3},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
AU  - Evangelou,E
AU  - Gao,H
AU  - Blakeley,P
AU  - Pazoki,R
AU  - Suzuki,H
AU  - Elliott,J
AU  - Karaman,I
AU  - Jarvelin,MR
AU  - Tzoulaki,I
AU  - Bell,JD
AU  - Matthews,PM
AU  - Elliott,P
DO  - 10.1038/s41562-019-0653-z
EP  - 961
PY  - 2019///
SN  - 2397-3374
SP  - 950
TI  - New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
T2  - Nature Human Behaviour
UR  - http://dx.doi.org/10.1038/s41562-019-0653-z
UR  - https://www.nature.com/articles/s41562-019-0653-z
UR  - http://hdl.handle.net/10044/1/72192
VL  - 3
ER  -
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