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@article{Datta:2016:10.1177/1352458516681504,
author = {Datta, G and Violante, IR and Scott, G and Zimmerman, K and Santos-Ribeiro, A and Rabiner, EA and Gunn, RN and Malik, O and Ciccarelli, O and Nicholas, R and Matthews, PM},
doi = {10.1177/1352458516681504},
journal = {Multiple Sclerosis},
pages = {1469--1478},
title = {Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.},
url = {http://dx.doi.org/10.1177/1352458516681504},
volume = {23},
year = {2016}
}

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TY  - JOUR
AB  - BACKGROUND: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this. OBJECTIVE: To explore the in vivo relationships between MRS and PET [(11)C]PBR28 in MS over a range of brain inflammatory burden. METHODS: A total of 23 patients were studied. TSPO PET imaging with [(11)C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC). RESULTS: [(11)C]PBR28 uptake and [ myo-inositol] were not associated. When the whole cohort was stratified by higher [(11)C]PBR28 inflammatory burden, [ myo-inositol] was positively correlated to [(11)C]PBR28 uptake (Spearman's ρ = 0.685, p = 0.014). Moderate correlations were found between [(11)C]PBR28 uptake and both MRS creatine normalised N-acetyl aspartate (NAA) concentration and grey matter volume. MSFC was correlated with grey matter volume (ρ = 0.535, p = 0.009). There were no associations between other imaging or clinical measures. CONCLUSION: MRS [ myo-inositol] and PET [(11)C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [(11)C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy.
AU  - Datta,G
AU  - Violante,IR
AU  - Scott,G
AU  - Zimmerman,K
AU  - Santos-Ribeiro,A
AU  - Rabiner,EA
AU  - Gunn,RN
AU  - Malik,O
AU  - Ciccarelli,O
AU  - Nicholas,R
AU  - Matthews,PM
DO  - 10.1177/1352458516681504
EP  - 1478
PY  - 2016///
SN  - 1352-4585
SP  - 1469
TI  - Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
T2  - Multiple Sclerosis
UR  - http://dx.doi.org/10.1177/1352458516681504
UR  - http://hdl.handle.net/10044/1/51598
VL  - 23
ER  -

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