Imperial College London
Alternate

Dr Paul F. McKay

Faculty of Medicine, Department of Infectious Disease

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2542p.mckay

 
 
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Location

 

125 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brown:2021:10.1101/2021.02.24.432576,
author = {Brown, JC and Goldhill, DH and Zhou, J and Peacock, TP and Frise, R and Goonawardane, N and Baillon, L and Kugathasan, R and Pinto, AL and McKay, PF and Hassard, J and Moshe, M and Singanayagam, A and Burgoyne, T and Barclay, WS},
doi = {10.1101/2021.02.24.432576},
title = {Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape},
url = {http://dx.doi.org/10.1101/2021.02.24.432576},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Lineage B.1.1.7 (Variant of Concern 202012/01) is a new SARS-CoV-2 variant which was first sequenced in the UK in September 2020 before becoming the majority strain in the UK and spreading worldwide. The rapid spread of the B.1.1.7 variant results from increased transmissibility but the virological characteristics which underpin this advantage over other circulating strains remain unknown. Here, we demonstrate that there is no difference in viral replication between B.1.1.7 and other contemporaneous SARS-CoV-2 strains in primary human airway epithelial (HAE) cells. However, B.1.1.7 replication is disadvantaged in Vero cells potentially due to increased furin-mediated cleavage of its spike protein as a result of a P681H mutation directly adjacent to the S1/S2 cleavage site. In addition, we show that B.1.1.7 does not escape neutralisation by convalescent or post-vaccination sera. Thus, increased transmission of B.1.1.7 is not caused by increased replication, as measured on HAE cells, or escape from serological immunity.</jats:p>
AU  - Brown,JC
AU  - Goldhill,DH
AU  - Zhou,J
AU  - Peacock,TP
AU  - Frise,R
AU  - Goonawardane,N
AU  - Baillon,L
AU  - Kugathasan,R
AU  - Pinto,AL
AU  - McKay,PF
AU  - Hassard,J
AU  - Moshe,M
AU  - Singanayagam,A
AU  - Burgoyne,T
AU  - Barclay,WS
DO  - 10.1101/2021.02.24.432576
PY  - 2021///
TI  - Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape
UR  - http://dx.doi.org/10.1101/2021.02.24.432576
ER  -
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