Imperial College London
Alternate

Dr Paul F. McKay

Faculty of Medicine, Department of Infectious Disease

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2542p.mckay

 
 
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Location

 

125 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhou:2021:rs.3.rs-829214/v1,
author = {Zhou, J and Peacock, T and Brown, J and Goldhill, D and Elrefaey, A and Penrice-Randal, R and Cowton, V and De, Lorenzo G and Furnon, W and Harvey, W and Kugathasan, R and Frise, R and Baillon, L and Lassauniere, R and Thakur, N and Gallo, G and Goldswain, H and Donovan-Banfield, I and Dong, X and Randle, N and Sweeney, F and Glynn, M and Quantrill, J and McKay, P and Patel, A and Palmarini, M and Hiscox, J and Bailey, D and Barclay, W},
doi = {rs.3.rs-829214/v1},
title = {Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.},
url = {http://dx.doi.org/10.21203/rs.3.rs-829214/v1},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title>        <jats:p>SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of the 2019 pandemic several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T all specifically adapt SARS-CoV-2 to use mustelid ACE2. Furthermore, we risk assess these mutations and conclude mink-adapted viruses are unlikely to pose an increased threat to humans, as Y453F attenuates the virus replication in human cells and all 3 mink-adaptations have minimal antigenic impact. Finally, we show that certain SARS-CoV-2 variants emerging from circulation in humans may naturally have a greater propensity to infect mustelid hosts and therefore these species should continue to be surveyed for reverse zoonotic infections.</jats:p>
AU  - Zhou,J
AU  - Peacock,T
AU  - Brown,J
AU  - Goldhill,D
AU  - Elrefaey,A
AU  - Penrice-Randal,R
AU  - Cowton,V
AU  - De,Lorenzo G
AU  - Furnon,W
AU  - Harvey,W
AU  - Kugathasan,R
AU  - Frise,R
AU  - Baillon,L
AU  - Lassauniere,R
AU  - Thakur,N
AU  - Gallo,G
AU  - Goldswain,H
AU  - Donovan-Banfield,I
AU  - Dong,X
AU  - Randle,N
AU  - Sweeney,F
AU  - Glynn,M
AU  - Quantrill,J
AU  - McKay,P
AU  - Patel,A
AU  - Palmarini,M
AU  - Hiscox,J
AU  - Bailey,D
AU  - Barclay,W
DO  - rs.3.rs-829214/v1
PY  - 2021///
TI  - Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.
UR  - http://dx.doi.org/10.21203/rs.3.rs-829214/v1
ER  -
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