Imperial College London
Alternate

Dr Paul F. McKay

Faculty of Medicine, Department of Infectious Disease

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2542p.mckay

 
 
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Location

 

125 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhou:2021:10.1101/2021.08.20.456972,
author = {Zhou, J and Peacock, TP and Brown, JC and Goldhill, DH and Elrefaey, AME and Penrice-Randal, R and Cowton, VM and Lorenzo, GD and Furnon, W and Harvey, WT and Kugathasan, R and Frise, R and Baillon, L and Lassaunière, R and Thakur, N and Gallo, G and Goldswain, H and Donovan-Banfield, I and Dong, X and Randle, NP and Sweeney, F and Glynn, MC and Quantrill, JL and McKay, PF and Patel, AH and Palmarini, M and Hiscox, JA and Bailey, D and Barclay, WS},
doi = {10.1101/2021.08.20.456972},
title = {Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway},
url = {http://dx.doi.org/10.1101/2021.08.20.456972},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of the 2019 pandemic several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T all specifically adapt SARS-CoV-2 to use mustelid ACE2. Furthermore, we risk assess these mutations and conclude mink-adapted viruses are unlikely to pose an increased threat to humans, as Y453F attenuates the virus replication in human cells and all 3 mink-adaptations have minimal antigenic impact. Finally, we show that certain SARS-CoV-2 variants emerging from circulation in humans may naturally have a greater propensity to infect mustelid hosts and therefore these species should continue to be surveyed for reverse zoonotic infections.</jats:p>
AU  - Zhou,J
AU  - Peacock,TP
AU  - Brown,JC
AU  - Goldhill,DH
AU  - Elrefaey,AME
AU  - Penrice-Randal,R
AU  - Cowton,VM
AU  - Lorenzo,GD
AU  - Furnon,W
AU  - Harvey,WT
AU  - Kugathasan,R
AU  - Frise,R
AU  - Baillon,L
AU  - Lassaunière,R
AU  - Thakur,N
AU  - Gallo,G
AU  - Goldswain,H
AU  - Donovan-Banfield,I
AU  - Dong,X
AU  - Randle,NP
AU  - Sweeney,F
AU  - Glynn,MC
AU  - Quantrill,JL
AU  - McKay,PF
AU  - Patel,AH
AU  - Palmarini,M
AU  - Hiscox,JA
AU  - Bailey,D
AU  - Barclay,WS
DO  - 10.1101/2021.08.20.456972
PY  - 2021///
TI  - Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway
UR  - http://dx.doi.org/10.1101/2021.08.20.456972
ER  -
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