Imperial College London
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ProfessorPhilipMolyneaux

Faculty of Medicine, National Heart & Lung Institute

Professor of Interstitial Lung Disease
 
 
 
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Contact

 

p.molyneaux

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Spagnolo:2019:10.3390/ijms20225618,
author = {Spagnolo, P and Molyneaux, PL and Bernardinello, N and Cocconcelli, E and Biondini, D and Fracasso, F and Tiné, M and Saetta, M and Maher, TM and Balestro, E},
doi = {10.3390/ijms20225618},
journal = {International Journal of Molecular Sciences},
title = {The role of the lung's microbiome in the pathogenesis and progression of idiopathic pulmonary fibrosis},
url = {http://dx.doi.org/10.3390/ijms20225618},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease that commonly affects older adults and is associated with the histopathological and/or radiological patterns of usual interstitial pneumonia (UIP). Despite significant advances in our understanding of disease pathobiology and natural history, what causes IPF remains unknown. A potential role for infection in the disease's pathogenesis and progression or as a trigger of acute exacerbation has long been postulated, but initial studies based on traditional culture methods have yielded inconsistent results. The recent application to IPF of culture-independent techniques for microbiological analysis has revealed previously unappreciated alterations of the lung microbiome, as well as an increased bacterial burden in the bronchoalveolar lavage (BAL) of IPF patients, although correlation does not necessarily entail causation. In addition, the lung microbiome remains only partially characterized and further research should investigate organisms other than bacteria and viruses, including fungi. The clarification of the role of the microbiome in the pathogenesis and progression of IPF may potentially allow its manipulation, providing an opportunity for targeted therapeutic intervention.
AU  - Spagnolo,P
AU  - Molyneaux,PL
AU  - Bernardinello,N
AU  - Cocconcelli,E
AU  - Biondini,D
AU  - Fracasso,F
AU  - Tiné,M
AU  - Saetta,M
AU  - Maher,TM
AU  - Balestro,E
DO  - 10.3390/ijms20225618
PY  - 2019///
SN  - 1422-0067
TI  - The role of the lung's microbiome in the pathogenesis and progression of idiopathic pulmonary fibrosis
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms20225618
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31717661
UR  - http://hdl.handle.net/10044/1/75231
VL  - 20
ER  -
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