Imperial College London
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ProfessorPhilipMolyneaux

Faculty of Medicine, National Heart & Lung Institute

Professor of Interstitial Lung Disease
 
 
 
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p.molyneaux

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Macaluso:2022:10.1111/resp.14204,
author = {Macaluso, C and Boccabella, C and Kokosi, M and Sivarasan, N and Kouranos, V and George, PM and Margaritopoulos, G and Molyneaux, PL and Chua, F and Maher, TM and Jenkins, GR and Nicholson, AG and Desai, SR and Devaraj, A and Wells, AU and Renzoni, EA and Stock, CJW},
doi = {10.1111/resp.14204},
journal = {Respirology},
pages = {202--208},
title = {Short-term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis},
url = {http://dx.doi.org/10.1111/resp.14204},
volume = {27},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and objectiveA proportion of patients with fibrotic hypersensitivity pneumonitis (fHP) follow a progressive disease course despite immunosuppressive treatment. Little is known about predictors of mortality in fHP. We aimed to investigate the impact of short-term lung function changes in fHP on mortality.MethodsBaseline demographics for 145 consecutive patients with a multi-disciplinary team diagnosis of fHP, as well as baseline and 1-year follow-up of lung function, baseline echocardiographic findings, bronchoalveolar lavage (BAL) cellularity and all-cause mortality were recorded. Changes in forced vital capacity (FVC) ≥ 5% and ≥10%, and diffusion capacity of the lung for carbon monoxide (DLCO) ≥ 10% and ≥15% at 1 year were calculated. Cox proportional hazards analysis was performed to test for associations with mortality.ResultsBaseline lung function severity, age, presence of honeycombing on computed tomography (CT) and echocardiographic pulmonary arterial systolic pressure (PASP) ≥ 40 mm Hg were associated with early mortality, while BAL lymphocytosis was associated with improved survival. A decline in FVC ≥ 5% (hazard ratio [HR]: 3.10, 95% CI: 2.00–4.81, p < 0.001), FVC ≥ 10% (HR: 3.11, 95% CI: 1.94–4.99, p < 0.001), DLCO ≥ 10% (HR: 2.80, 95% CI: 1.78–4.42, p < 0.001) and DLCO ≥ 15% (HR: 2.92, 95% CI: 1.18–4.72, p < 0.001) at 1 year was associated with markedly reduced survival on univariable and multivariable analyses after correcting for demographic variables, disease severity, honeycombing on CT and treatment, as well as BAL lymphocytosis and PASP ≥ 40 mm Hg on echocardiography, in separate models.ConclusionWorsening in FVC and DLCO at 1 year, including a marginal decline in FVC ≥ 5% and DLCO&th
AU  - Macaluso,C
AU  - Boccabella,C
AU  - Kokosi,M
AU  - Sivarasan,N
AU  - Kouranos,V
AU  - George,PM
AU  - Margaritopoulos,G
AU  - Molyneaux,PL
AU  - Chua,F
AU  - Maher,TM
AU  - Jenkins,GR
AU  - Nicholson,AG
AU  - Desai,SR
AU  - Devaraj,A
AU  - Wells,AU
AU  - Renzoni,EA
AU  - Stock,CJW
DO  - 10.1111/resp.14204
EP  - 208
PY  - 2022///
SN  - 1323-7799
SP  - 202
TI  - Short-term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis
T2  - Respirology
UR  - http://dx.doi.org/10.1111/resp.14204
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000741682700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/resp.14204
UR  - http://hdl.handle.net/10044/1/96193
VL  - 27
ER  -
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