Imperial College London
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ProfessorPhilipMolyneaux

Faculty of Medicine, National Heart & Lung Institute

Professor of Interstitial Lung Disease
 
 
 
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p.molyneaux

 
 
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Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Evans:2022:10.1016/s2213-2600(22)00127-8,
author = {Evans, RA and Leavy, OC and Richardson, M and Elneima, O and McCauley, HJC and Shikotra, A and Singapuri, A and Sereno, M and Saunders, RM and Harris, VC and Houchen-Wolloff, L and Aul, R and Beirne, P and Bolton, CE and Brown, JS and Choudhury, G and Diar-Bakerly, N and Easom, N and Echevarria, C and Fuld, J and Hart, N and Hurst, J and Jones, MG and Parekh, D and Pfeffer, P and Rahman, NM and Rowland-Jones, SL and Shah, AM and Wootton, DG and Chalder, T and Davies, MJ and De, Soyza A and Geddes, JR and Greenhalf, W and Greening, NJ and Heaney, LG and Heller, S and Howard, LS and Jacob, J and Jenkins, RG and Lord, JM and Man, WD-C and McCann, GP and Neubauer, S and Openshaw, PJM and Porter, JC and Rowland, MJ and Scott, JT and Semple, MG and Singh, SJ and Thomas, DC and Toshner, M and Lewis, KE and Thwaites, RS and Briggs, A and Docherty, AB and Kerr, S and Lone, NI and Quint, J and Sheikh, A and Thorpe, M and Zheng, B and Chalmers, JD and Ho, LP and Horsley, A and Marks, M and Poinas},
doi = {10.1016/s2213-2600(22)00127-8},
journal = {The Lancet Respiratory Medicine},
pages = {761--775},
title = {Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study},
url = {http://dx.doi.org/10.1016/s2213-2600(22)00127-8},
volume = {10},
year = {2022}
}
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TY  - JOUR
AB  - BackgroundNo effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge.MethodsThe Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing.Findings2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32·7%) participants completed both the 5-month and 1-year visits. 279 (35·6%) of these 807 patients were women and 505 (64·4%) were men, with a mean age of 58·7 (SD 12·5) years, and 224 (27·8%) had received invasive mechanical ventilation (WHO class 7–9). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0·68 [95% CI 0·46–0·99]), obes
AU  - Evans,RA
AU  - Leavy,OC
AU  - Richardson,M
AU  - Elneima,O
AU  - McCauley,HJC
AU  - Shikotra,A
AU  - Singapuri,A
AU  - Sereno,M
AU  - Saunders,RM
AU  - Harris,VC
AU  - Houchen-Wolloff,L
AU  - Aul,R
AU  - Beirne,P
AU  - Bolton,CE
AU  - Brown,JS
AU  - Choudhury,G
AU  - Diar-Bakerly,N
AU  - Easom,N
AU  - Echevarria,C
AU  - Fuld,J
AU  - Hart,N
AU  - Hurst,J
AU  - Jones,MG
AU  - Parekh,D
AU  - Pfeffer,P
AU  - Rahman,NM
AU  - Rowland-Jones,SL
AU  - Shah,AM
AU  - Wootton,DG
AU  - Chalder,T
AU  - Davies,MJ
AU  - De,Soyza A
AU  - Geddes,JR
AU  - Greenhalf,W
AU  - Greening,NJ
AU  - Heaney,LG
AU  - Heller,S
AU  - Howard,LS
AU  - Jacob,J
AU  - Jenkins,RG
AU  - Lord,JM
AU  - Man,WD-C
AU  - McCann,GP
AU  - Neubauer,S
AU  - Openshaw,PJM
AU  - Porter,JC
AU  - Rowland,MJ
AU  - Scott,JT
AU  - Semple,MG
AU  - Singh,SJ
AU  - Thomas,DC
AU  - Toshner,M
AU  - Lewis,KE
AU  - Thwaites,RS
AU  - Briggs,A
AU  - Docherty,AB
AU  - Kerr,S
AU  - Lone,NI
AU  - Quint,J
AU  - Sheikh,A
AU  - Thorpe,M
AU  - Zheng,B
AU  - Chalmers,JD
AU  - Ho,LP
AU  - Horsley,A
AU  - Marks,M
AU  - Poinasamy,K
AU  - Raman,B
AU  - Harrison,EM
AU  - Wain,LV
AU  - Brightling,CE
AU  - Abel,K
AU  - Adamali,H
AU  - Adeloye,D
AU  - Adeyemi,O
AU  - Adrego,R
AU  - Aguilar,Jimenez LA
AU  - Ahmad,S
AU  - Ahmad,Haider N
AU  - Ahmed,R
AU  - Ahwireng,N
AU  - Ainsworth,M
AU  - Al-Sheklly,B
AU  - Alamoudi,A
AU  - Ali,M
AU  - Aljaroof,M
AU  - All,AM
AU  - Allan,L
AU  - Allen,RJ
AU  - Allerton,L
AU  - Allsop,L
AU  - Almeida,P
AU  - Altmann,D
AU  - Alvarez,Corral M
AU  - Amoils,S
AU  - Anderson,D
AU  - Antoniades,C
AU  - Arbane,G
AU  - Arias,A
AU  - Armour,C
AU  - Armstrong,L
AU  - Armstrong,N
AU  - Arnold,D
AU  - Arnold,H
AU  - Ashish,A
AU  - Ashworth,A
AU  - Ashworth,M
AU  - Aslani,S
AU  - Assefa-Kebede,H
AU  - Atkin,C
AU  - Atkin,P
AU  - Aung,H
AU  - Austin,L
AU  - Avram,C
AU  - Ayoub,A
AU  - Babores,M
AU  - Baggott,R
AU  - Bagshaw,J
AU  - Baguley,D
AU  - Bailey,L
AU  - Baillie,JK
AU  - Bain,S
AU  - Bakali,M
AU  - Bakau,M
AU  - Baldry,E
AU  - Baldwin,D
AU  - Ballard,C
AU  - Banerjee,A
AU  - Bang,B
AU  - Barker,RE
AU  - Barman,L
AU  - Barratt,S
AU  - Barrett,F
AU  - Basire,D
AU  - Basu,N
AU  - Bates,M
AU  - Bates,A
AU  - Batterham,R
AU  - Baxendale,H
AU  - Bayes,H
AU  - Beadsworth,M
AU  - Beckett,P
AU  - Beggs,M
AU  - Begum,M
AU  - Bell,D
AU  - Bell,R
AU  - Bennett,K
AU  - Beranova,E
AU  - Bermperi,A
AU  - Berridge,A
AU  - Berry,C
AU  - Betts,S
AU  - Bevan,E
AU  - Bhui,K
AU  - Bingham,M
AU  - Birchall,K
AU  - Bishop,L
AU  - Bisnauthsing,K
AU  - Blaikely,J
AU  - Bloss,A
AU  - Bolger,A
AU  - Bonnington,J
AU  - Botkai,A
AU  - Bourne,C
AU  - Bourne,M
AU  - Bramham,K
AU  - Brear,L
AU  - Breen,G
AU  - Breeze,J
AU  - Bright,E
AU  - Brill,S
AU  - Brindle,K
AU  - Broad,L
AU  - Broadley,A
AU  - Brookes,C
AU  - Broome,M
AU  - Brown,A
AU  - Brown,A
AU  - Brown,J
AU  - Brown,J
AU  - Brown,M
AU  - Brown,M
AU  - Brown,V
AU  - Brugha,T
AU  - Brunskill,N
DO  - 10.1016/s2213-2600(22)00127-8
EP  - 775
PY  - 2022///
SN  - 2213-2600
SP  - 761
TI  - Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
T2  - The Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/s2213-2600(22)00127-8
UR  - https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00127-8/fulltext
UR  - http://hdl.handle.net/10044/1/97384
VL  - 10
ER  -
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