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@article{Molyneaux:2017:10.1186/s12931-017-0511-3,
author = {Molyneaux, PL and Cox, MJ and Wells, AU and Kim, HC and Ji, W and Cookson, WOC and Moffatt, MF and Kim, DS and Maher, TM},
doi = {10.1186/s12931-017-0511-3},
journal = {Respiratory Research},
title = {Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis},
url = {http://dx.doi.org/10.1186/s12931-017-0511-3},
volume = {18},
year = {2017}
}

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TY  - JOUR
AB  - Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an unidentifiable cause. They carry a significant mortality and morbidity and while their exact pathogenesis remains unclear, the possibility remains that hidden infection may play a role. The aim of this pilot study was to determine whether changes in the respiratory microbiota occur during an AE-IPF. Bacterial DNA was extracted from bronchoalveolar lavage from patients with stable IPF and those experiencing an AE-IPF. A hyper-variable region of the 16S ribosomal RNA gene (16S rRNA) was amplified, quantified and pyrosequenced. Culture independent techniques demonstrate AE-IPF is associated with an increased BAL bacterial burden compared to stable disease and highlight shifts in the composition of the respiratory microbiota during an AE-IPF.
AU  - Molyneaux,PL
AU  - Cox,MJ
AU  - Wells,AU
AU  - Kim,HC
AU  - Ji,W
AU  - Cookson,WOC
AU  - Moffatt,MF
AU  - Kim,DS
AU  - Maher,TM
DO  - 10.1186/s12931-017-0511-3
PY  - 2017///
SN  - 1465-9921
TI  - Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-017-0511-3
UR  - http://hdl.handle.net/10044/1/52223
VL  - 18
ER  -

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