Imperial College London
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ProfessorPhilipMolyneaux

Faculty of Medicine, National Heart & Lung Institute

Professor of Interstitial Lung Disease
 
 
 
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Contact

 

p.molyneaux

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Faner:2017:10.1183/13993003.02086-2016,
author = {Faner, R and Sibila, O and Agustí, A and Bernasconi, E and Chalmers, JD and Huffnagle, GB and Manichanh, C and Molyneaux, PL and Paredes, R and Pérez, Brocal V and Ponomarenko, J and Sethi, S and Dorca, J and Monsó, E},
doi = {10.1183/13993003.02086-2016},
journal = {European Respiratory Journal},
title = {The microbiome in respiratory medicine: current challenges and future perspectives},
url = {http://dx.doi.org/10.1183/13993003.02086-2016},
volume = {49},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The healthy lung has previously been considered to be a sterile organ because standard microbiological culture techniques consistently yield negative results. However, culture-independent techniques report that large numbers of microorganisms coexist in the lung. There are many unknown aspects in the field, but available reports show that the lower respiratory tract microbiota: 1) is similar in healthy subjects to the oropharyngeal microbiota and dominated by members of the Firmicutes, Bacteroidetes and Proteobacteria phyla; 2) shows changes in smokers and well-defined differences in chronic respiratory diseases, although the temporal and spatial kinetics of these changes are only partially known; and 3) shows relatively abundant non-cultivable bacteria in chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis and bronchiectasis, with specific patterns for each disease. In all of these diseases, a loss of diversity, paralleled by an over-representation of Proteobacteria (dysbiosis), has been related to disease severity and exacerbations. However, it is unknown whether dysbiosis is a cause or a consequence of the damage to bronchoalveolar surfaces.Finally, little is known about bacterial functionality and the interactions between viruses, fungi and bacteria. It is expected that future research in bacterial gene expressions, metagenomics longitudinal analysis and host-microbiome animal models will help to move towards targeted microbiome interventions in respiratory diseases.
AU  - Faner,R
AU  - Sibila,O
AU  - Agustí,A
AU  - Bernasconi,E
AU  - Chalmers,JD
AU  - Huffnagle,GB
AU  - Manichanh,C
AU  - Molyneaux,PL
AU  - Paredes,R
AU  - Pérez,Brocal V
AU  - Ponomarenko,J
AU  - Sethi,S
AU  - Dorca,J
AU  - Monsó,E
DO  - 10.1183/13993003.02086-2016
PY  - 2017///
SN  - 0903-1936
TI  - The microbiome in respiratory medicine: current challenges and future perspectives
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.02086-2016
UR  - http://hdl.handle.net/10044/1/75862
VL  - 49
ER  -
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