Imperial College London
Alternate

DrPaoloMontaldo

Faculty of Medicine, Department of Brain Sciences

Honorary Research Fellow
 
 
 
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Contact

 

p.montaldo

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Montaldo:2022:10.1038/s41598-022-09199-5,
author = {Montaldo, P and Puzone, S and Caredda, E and Pugliese, U and Inserra, E and Cirillo, G and Gicchino, F and Campana, G and Ursi, D and Galdo, F and Internicola, M and Spagnuolo, F and Carpentieri, M and Capristo, C and Marzuillo, P and Miraglia, Del Giudice E},
doi = {10.1038/s41598-022-09199-5},
journal = {Scientific Reports},
pages = {1--9},
title = {Impact of intrauterine growth restriction on cerebral and renal oxygenation and perfusion during the first 3 days after birth},
url = {http://dx.doi.org/10.1038/s41598-022-09199-5},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Intrauterine growth restriction (IUGR) is associated with a higher incidence of perinatal complications as well as cardiovascular and renal diseases later on. A better insight into the disease mechanisms underlying these sequalae is important in order to identify which IUGR infants are at a higher risk and find strategies to improve their outcome. In this prospective case–control study we examined whether IUGR had any effect on renal and cerebral perfusion and oxygen saturation in term neonates. We integrated near-infrared spectroscopy (NIRS), echocardiographic, Doppler and renal function data of 105 IUGR infants and 105 age/gender-matched controls. Cerebral and renal regional oxygen saturation values were measured by NIRS during the first 12 h after birth. Echocardiography alongside Doppler assessment of renal and anterior cerebral arteries were performed at 6, 24, 48 and 72 h of age. Glomerular and tubular functions were also assessed. We found a left ventricular dysfunction together with a higher cerebral oxygen saturation and perfusion values in the IUGR group. IUGR term infants showed a higher renal oxygen saturation and a reduced oxygen extraction together with a subclinical renal damage, as indicated by higher values of urinary neutrophil gelatinase-associated lipocalin and microalbumin. These data suggest that some of the haemodynamic changes present in growth-restricted foetuses may persist postnatally. The increased cerebral oxygenation may suggest an impaired transition to normal autoregulation as a consequence of intra-uterine chronic hypoxia. The higher renal oxygenation may reflect a reduced renal oxygen consumption due to a subclinical kidney damage.
AU  - Montaldo,P
AU  - Puzone,S
AU  - Caredda,E
AU  - Pugliese,U
AU  - Inserra,E
AU  - Cirillo,G
AU  - Gicchino,F
AU  - Campana,G
AU  - Ursi,D
AU  - Galdo,F
AU  - Internicola,M
AU  - Spagnuolo,F
AU  - Carpentieri,M
AU  - Capristo,C
AU  - Marzuillo,P
AU  - Miraglia,Del Giudice E
DO  - 10.1038/s41598-022-09199-5
EP  - 9
PY  - 2022///
SN  - 2045-2322
SP  - 1
TI  - Impact of intrauterine growth restriction on cerebral and renal oxygenation and perfusion during the first 3 days after birth
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-022-09199-5
UR  - https://www.nature.com/articles/s41598-022-09199-5
UR  - http://hdl.handle.net/10044/1/96042
VL  - 12
ER  -
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