Imperial College London
Portrait Picture

ProfessorPaoloMuraro

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology - Neuroimmunology and Immunotherapy
 
 
 
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Contact

 

p.muraro Website

 
 
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Assistant

 

Mrs Gearoidin Beazley +44 (0)20 7594 7047

 
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Location

 

E415Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

243 results found

Saccardi R, Freedman M, Sormani MP, Atkins H, Farge D, Griffith L, Kraft G, Mancardi G, Nash R, Pasquini M, Martin R, Muraro Pet al., 2012, A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper, Multiple Sclerosis

Journal article

Atkins HL, Muraro PA, van Laar JM, Pavletic SZet al., 2012, Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease-Is It Now Ready for Prime Time?, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol: 18, Pages: S177-S183, ISSN: 1083-8791

Journal article

Nash RA, Hutton GJ, Racke MK, Popat UR, Devine SM, Griffith LM, Muraro PA, Openshaw H, Sayre PH, Stuve O, Arnold DL, Wruck L, Wundes A, Kraft GH, Bowen JDet al., 2011, Treatment of Severe Relapsing-Remitting Multiple Sclerosis with High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation: Early Results of the HALT MS Clinical Trial (Immune Tolerance Network: ITN033AI), 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1326-1327, ISSN: 0006-4971

Conference paper

Mattoscio M, Nicholas R, Malik O, Dazzi F, Muraro PAet al., 2011, Differential increase of circulating haematopoietic stem cells following therapeutic alpha 4-integrin blockade in multiple sclerosis: definition of mobilisers versus non-mobilisers subjects and clinical correlations, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S191-S191, ISSN: 1352-4585

Journal article

Scalfari A, Neuhaus A, Daumer M, Muraro P, Ebers Get al., 2011, The onset of secondary progression is the key determinant of long-term disease evolution, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S73-S74, ISSN: 1352-4585

Journal article

Abrahamsson S, Dubinsky A, Angelini D, Oh U, Battistini L, Martin R, Mancardi G, Burt R, Muraro Pet al., 2011, Immune reconstitution after haematopoietic stem cell transplantation depends on the specific immunosuppressive protocol, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S46-S47, ISSN: 1352-4585

Journal article

Scalfari A, Neuhaus A, Daumer M, Muraro PA, Ebers Get al., 2011, Inflammation and disability accumulation: do relapses really matter?, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S299-S299, ISSN: 1352-4585

Journal article

Martin R, Schippling S, Farge-Bancel D, Sormani MP, Muraro PA, Mancardi G, Saccardi Ret al., 2011, Autologous hamatopoietic stem cell transplantation in multiple sclerosis - Current state and outline of a phase III trial, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S195-S195, ISSN: 1352-4585

Journal article

Scalfari A, Neuhaus A, Daumer M, Ebers GC, Muraro PAet al., 2011, Age and disability accumulation in multiple sclerosis, NEUROLOGY, Vol: 77, Pages: 1246-1252, ISSN: 0028-3878

Journal article

Scalfari A, Giannetti P, Neuhaus A, Daumer M, Muraro PA, Ebers Get al., 2011, Frequent early relapses and long-term disease evolution in multiple sclerosis, 21st Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: 95-95, ISSN: 0340-5354

Conference paper

Kiferle L, Politis M, Muraro PA, Piccini Pet al., 2011, Positron emission tomography imaging in multiple sclerosis-current status and future applications, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 18, Pages: 226-231, ISSN: 1351-5101

Journal article

Nicholas R, Giannetti P, Alsanousi A, Friede T, Muraro PAet al., 2011, Development of oral immunomodulatory agents in the management of multiple sclerosis., Drug Des Devel Ther, Vol: 5, Pages: 255-274

The emergence of oral disease-modifying therapies in multiple sclerosis (MS) will have a significant impact on the evolving scenario of immunomodulatory treatments in MS where current therapies are all injectable. Reducing relapses in trials translates for individuals with MS into a therapeutic aim of stopping future events. Thus the possible absence of any perceived benefits to the individual together with the long disease course, variable outcome, and a younger age group affected in MS makes side effects the major issue. The use of disease-modifying therapies as a whole needs to be placed in the context of a widening therapeutic indication where the use of these therapies is being justified at an increasingly early stage and in pre-MS syndromes such as clinically isolated and radiologically isolated syndromes where no fixed disability is likely to have accumulated. The five oral therapies discussed (cladribine, fingolimod, laquinimod, BG-12, and teriflunomide) have just completed Phase III studies and some have just been licensed. New oral drugs for MS need to be placed within this evolving marketplace where ease of delivery together with efficacy and side effects needs to be balanced against the known issues but also the known long-term safety of standard injectables.

Journal article

Ebers G, Neuhaus A, Muraro P, Daumer M, Harner N, Degenhardt A, Rice GP, Scalfari Aet al., 2010, THE NATURAL HISTORY OF MULTIPLE SCLEROSIS, A GEOGRAPHICALLY BASED STUDY. 10: RELAPSES AND LONG-TERM DISABILITY, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: E31-E31, ISSN: 0022-3050

Conference paper

Muraro PA, Abrahamsson SV, 2010, Resetting autoimmunity in the nervous system: The role of hematopoietic stem cell transplantation, CURRENT OPINION IN INVESTIGATIONAL DRUGS, Vol: 11, Pages: 1265-1275, ISSN: 1472-4472

Journal article

Nicholas R, D'Arcy C, Muraro P, McGuigan C, Malik O, Giannetti P, O'Driscoll Set al., 2010, USING NATALIZUMAB IN HIGHLY ACTIVE RELAPSING REMITTING MULTIPLE SCLEROSIS IN THE UK, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: E53-E53, ISSN: 0022-3050

Conference paper

Pasquini MC, Griffith LM, Arnold DL, Atkins HL, Bowen JD, Chen JT, Freedman MS, Kraft GH, Mancardi GL, Martin R, Muraro PA, Nash RA, Racke MK, Storek J, Saccardi Ret al., 2010, Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Collaboration of the CIBMTR and EBMT to Facilitate International Clinical Studies, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol: 16, Pages: 1076-1083, ISSN: 1083-8791

Journal article

Scalfari A, Neuhaus A, Degenhardt A, Rice GP, Muraro PA, Daumer M, Ebers GCet al., 2010, The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability, BRAIN, Vol: 133, Pages: 1914-1929, ISSN: 0006-8950

Journal article

Tappenden P, Saccardi R, Confavreux C, Sharrack B, Muraro PA, Mancardi GL, Kozak T, Farge-Bancel D, Madan J, Rafia R, Akehurst R, Snowden Jet al., 2010, Autologous haematopoietic stem cell transplantation for secondary progressive multiple sclerosis: an exploratory cost-effectiveness analysis, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: 1014-1021, ISSN: 0268-3369

Journal article

Mattoscio M, Nicholas R, Malik O, Mc Guigan C, Dazzi F, Muraro PAet al., 2010, Functional relevance of haematopoietic stem cell mobilization following therapeutic α 4-integrin blockade in multiple sclerosis: preliminary data, 20th Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: S221-S221, ISSN: 0340-5354

Conference paper

Scalfari A, Neuhaus A, Daumer M, Ebers G, Muraro PAet al., 2010, The effect of age on disability development in multiple sclerosis, 20th Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: S74-S74, ISSN: 0340-5354

Conference paper

Illei GG, Nikolov NP, Hakim F, Leitman S, Yarboro C, Balow J, Austin H, Gea-Banacloche J, Muraro P, Oh U, Odom J, Hardwick D, Muraro P, Sportes C, Lipsky P, Gress R, Pavletic Set al., 2010, LONG-TERM OUTCOMES OF AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO HSCT) USING LYMPHOABLATIVE CONDITIONING REGIMEN IN SYSTEMIC LUPUS ERYTHEMATOSUS - THE NIH EXPERIENCE, Conference on Haematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases, Publisher: NATURE PUBLISHING GROUP, Pages: S6-S6, ISSN: 0268-3369

Conference paper

Freedman M, Amato MP, Atkins H, Carreras E, Fassas A, Griffith LM, Kerr D, Martin R, Massacesi L, Muraro P, Nash R, Pasquini M, Saccardi R, Sormani MP, Mancardi Get al., 2010, Panel Session Report: Multiple Sclerosis, Conference on Haematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases, Publisher: NATURE PUBLISHING GROUP, Pages: S8-S10, ISSN: 0268-3369

Conference paper

Muraro PA, 2010, Restoring self tolerance: lessons from the clinic, Conference on Haematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases, Publisher: NATURE PUBLISHING GROUP, Pages: S2-S2, ISSN: 0268-3369

Conference paper

Dubinsky AN, Burt RK, Martin R, Muraro PAet al., 2010, T-cell clones persisting in the circulation after autologous hematopoietic SCT are undetectable in the peripheral CD34+selected graft, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: 325-331, ISSN: 0268-3369

Journal article

Abrahamsson S, Dubinsky A, Angelini D, Oh U, Battistini L, Martin R, Burt R, Muraro PAet al., 2010, AUTOLOGOUS NON-MYELOABLATIVE HAEMATOPOIETIC STEM CELL TRANSPLANTATION FAVOURABLY MODIFIES THE BALANCE OF REGULATORY AND PRO-INFLAMMATORY T CELL SUBSETS, Conference on Haematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases, Publisher: NATURE PUBLISHING GROUP, Pages: S18-S18, ISSN: 0268-3369

Conference paper

Sullivan KM, Muraro P, Tyndall A, 2010, Hematopoietic Cell Transplantation for Autoimmune Disease: Updates from Europe and the United States, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol: 16, Pages: S48-S56, ISSN: 1083-8791

Journal article

Muraro PA, Uccelli A, 2010, Immuno-Therapeutic Potential of Haematopoietic and Mesenchymal Stem Cell Transplantation in MS, MOLECULAR BASIS OF MULTIPLE SCLEROSIS: THE IMMUNE SYSTEM, Vol: 51, Pages: 237-257, ISSN: 0080-1844

Journal article

Muraro P, Van Laar J, Illei G, Pavletic Set al., 2009, Autoimmune disorders, Hematopoietic Stem Cell Transplantation in Clinical Practice, Pages: 197-210, ISBN: 9780443101472

Book chapter

Muraro P, 2009, Resetting autoimmunity in the nervous system; the role of bone marrow transplantation, 13th Congress of the European-Federation-of-Neurological-Societies, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 8-8, ISSN: 1351-5101

Conference paper

Mancardi GL, Gualandi F, Saccardi R, Muraro P, Van Lint MT, Sormani MP, Capello E, Leonardi A, Bonanni I, Roccatagliata L, Pardini M, Bonzano L, Uccelli A, Vuolo Let al., 2009, A prospective clinical and MRI study of a low-intensity conditioning regimen followed by autologous haematopoietic stem cell transplantation in severe multiple sclerosis, 25th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S253-S253, ISSN: 1352-4585

Conference paper

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