Imperial College London
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ProfessorPaoloMuraro

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology - Neuroimmunology and Immunotherapy
 
 
 
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Contact

 

p.muraro Website

 
 
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Assistant

 

Mrs Gearoidin Beazley +44 (0)20 7594 7047

 
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Location

 

E415Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Roberts:2020:10.3389/fneur.2020.556141,
author = {Roberts, F and Hobbs, H and Jessop, H and Bozzolini, C and Burman, J and Greco, R and Ismail, A and Kazmi, M and Kirgizov, K and Mancardi, G and Mawson, S and Muraro, PA and Puyade, M and Saccardi, R and Withers, B and Verhoeven, B and Sharrack, B and Snowden, JA},
doi = {10.3389/fneur.2020.556141},
journal = {Frontiers in Neurology},
pages = {1--13},
title = {Rehabilitation before and after Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for patients with Multiple Sclerosis (MS): consensus guidelines and recommendations for best clinical practice on behalf of the autoimmune diseases working party, nurses group, and patient advocacy committee of the European Society for Blood and Marrow Transplantation (EBMT)},
url = {http://dx.doi.org/10.3389/fneur.2020.556141},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby stabilizing, and, in some cases, reversing disability in carefully selected MS patients. However, AHSCT is an intensive chemotherapy-based procedure associated with intrinsic risks, including profound cytopenia, infection, and organ toxicity, accompanied by an on-going degree of immuno-compromise and general deconditioning, which can be associated with a transient increase in functional impairment in the early stages after transplantation. Although international guidelines and recommendations have been published for clinical and technical aspects of AHSCT in MS, there has been no detailed appraisal of the rehabilitation needed following treatment nor any specific guidelines as to how this is best delivered by hospital and community-based therapists and wider multidisciplinary teams in order to maximize functional recovery and quality of life. These expert consensus guidelines aim to address this unmet need by summarizing the evidence-base for AHSCT in MS and providing recommendations for current rehabilitation practice along with identifying areas for future research and development.
AU  - Roberts,F
AU  - Hobbs,H
AU  - Jessop,H
AU  - Bozzolini,C
AU  - Burman,J
AU  - Greco,R
AU  - Ismail,A
AU  - Kazmi,M
AU  - Kirgizov,K
AU  - Mancardi,G
AU  - Mawson,S
AU  - Muraro,PA
AU  - Puyade,M
AU  - Saccardi,R
AU  - Withers,B
AU  - Verhoeven,B
AU  - Sharrack,B
AU  - Snowden,JA
DO  - 10.3389/fneur.2020.556141
EP  - 13
PY  - 2020///
SN  - 1664-2295
SP  - 1
TI  - Rehabilitation before and after Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for patients with Multiple Sclerosis (MS): consensus guidelines and recommendations for best clinical practice on behalf of the autoimmune diseases working party, nurses group, and patient advocacy committee of the European Society for Blood and Marrow Transplantation (EBMT)
T2  - Frontiers in Neurology
UR  - http://dx.doi.org/10.3389/fneur.2020.556141
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000601600200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2020.556141/full
UR  - http://hdl.handle.net/10044/1/90739
VL  - 11
ER  -
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